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Biology and Biochemistry

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99
Citations
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World Ranking
1581
National Ranking
886

Medicine

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99
Citations
37779
World Ranking
8566
National Ranking
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Overview

Arlan Richardson is affiliated with the University of Oklahoma Health Sciences Center in the United States. Their research spans several areas within biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology and physiology as prominent subfields.

Their scientific output includes work on aging, muscle physiology, mitochondrial function, and mechanisms of cell death. The notable main topics of their research include:

  • Muscle Physiology and Disorders
  • Mitochondrial Function and Pathology
  • Adipose Tissue and Metabolism
  • Genetics, Aging, and Longevity in Model Organisms
  • Cell death mechanisms and regulation
  • Liver Disease Diagnosis and Treatment
  • Neuroinflammation and Neurodegeneration Mechanisms

Richardson's recent papers highlight his and collaborating authors' focus on aging, inflammation, fibrosis, and neuromuscular health. These include:

  • Effect of rapamycin on aging and age-related diseases-past and future (2020, GeroScience)
  • Necroptosis contributes to chronic inflammation and fibrosis in aging liver (2021, Aging Cell)
  • Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress (2021, Free Radical Biology and Medicine)
  • Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects (2020, Aging Cell)
  • Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia (2021, Journal of Cachexia Sarcopenia and Muscle)

Frequent co-authors contributing to the body of work with Richardson include Holly Van Remmen, Nidheesh Thadathil, Sathyaseelan S. Deepa, Ramasamy Selvarani, and Sabira Mohammed.

The primary venues for Dr. Richardson's publications reflect his concentration in aging and molecular biology fields, featuring:

  • GeroScience
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Aging Cell
  • The Journals of Gerontology Series A
  • Free Radical Biology and Medicine

This research activity underscores Richardson's engagement with experimental and clinical investigations related to aging processes, mitochondrial health, inflammation, fibrosis, and neuromuscular degeneration. Their work integrates molecular mechanisms with physiological outcomes relevant to muscle and liver function.

Best Publications

  • Geroscience: Linking Aging to Chronic Disease

    Brian K. Kennedy;Shelley L. Berger;Anne Brunet;Judith Campisi;Judith Campisi

  • Trends in oxidative aging theories

    Florian L. Muller;Michael S. Lustgarten;Youngmok Jang;Arlan Richardson;Arlan Richardson

  • Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

    Dudley W. Lamming;Lan Ye;Pekka Katajisto;Marcus D. Goncalves

  • Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

    Patricia Spilman;Natalia Podlutskaya;Matthew J. Hart;Jayanta Debnath

  • Does oxidative damage to DNA increase with age

    M. L. Hamilton;H. Van Remmen;J. A. Drake;H. Yang

  • Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau EFFECTS ON COGNITIVE IMPAIRMENTS

    Antonella Caccamo;Smita Majumder;Arlan Richardson;Arlan Richardson;Randy Strong;Randy Strong

  • Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

    Holly Van Remmen;Holly Van Remmen;Yuji Ikeno;Yuji Ikeno;Michelle Hamilton;Mohammad Pahlavani

  • The role of oxidative damage and stress in aging.

    Alex Bokov;Asish Chaudhuri;Asish Chaudhuri;Arlan Richardson;Arlan Richardson

  • THE SELENOPROTEIN GPX4 IS ESSENTIAL FOR MOUSE DEVELOPMENT AND PROTECTS FROM RADIATION AND OXIDATIVE DAMAGE INSULTS

    Levi J Yant;Qitao Ran;Lin Rao;Holly Van Remmen

  • Is the oxidative stress theory of aging dead

    Viviana I. Pérez;Alex Bokov;Holly Van Remmen;James Mele

  • Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice

    Melissa D. Williams;Holly Van Remmen;Holly Van Remmen;Craig C. Conrad;Craig C. Conrad;Ting Ting Huang

  • Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?

    Adam B. Salmon;Arlan Richardson;Arlan Richardson;Viviana I. Pérez

  • Methionine oxidation and aging

    Earl R. Stadtman;Holly Van Remmen;Arlan Richardson;Nancy B. Wehr

  • Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

    Viviana I. Pérez;Rochelle Buffenstein;Venkata Masamsetti;Shanique Leonard

  • Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

    Smita Majumder;Arlan Richardson;Arlan Richardson;Randy Strong;Randy Strong;Salvatore Oddo

  • The overexpression of major antioxidant enzymes does not extend the lifespan of mice

    Viviana I. Pérez;Holly Van Remmen;Alex Bokov;Charles J. Epstein

  • Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production.

    Florian L. Muller;Wook Song;Wook Song;Youngmok C. Jang;Yuhong Liu

  • Expression of heat shock protein 70 is altered by age and diet at the level of transcription

    Ahmad R. Heydari;Bo Wu;Ryoya Takahashi;Randy Strong

  • Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?

    JennaLynn Styskal;Holly Van Remmen;Holly Van Remmen;Arlan Richardson;Arlan Richardson;Adam B. Salmon;Adam B. Salmon

  • Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

    Youngmok C. Jang;Michael S. Lustgarten;Yuhong Liu;Florian L. Muller

Frequent Co-Authors

Holly Van Remmen
Holly Van Remmen Oklahoma Medical Research Foundation
Malcolm J. Jackson
Malcolm J. Jackson University of Liverpool
Jonathan D. Wren
Jonathan D. Wren Oklahoma Medical Research Foundation
Susan V. Brooks
Susan V. Brooks University of Michigan–Ann Arbor
Steven N. Austad
Steven N. Austad University of Alabama at Birmingham
Florian L. Muller
Florian L. Muller The University of Texas MD Anderson Cancer Center
Charles J. Epstein
Charles J. Epstein University of California, San Francisco
Ting-Ting Huang
Ting-Ting Huang Stanford University
Veronica Galvan
Veronica Galvan University of Oklahoma Health Sciences Center
John A. Faulkner
John A. Faulkner University of Michigan–Ann Arbor

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