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D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
16304
World Ranking
9580
National Ranking
4229

Overview

Jonathan D. Wren is affiliated with the Oklahoma Medical Research Foundation in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields, including molecular biology, immunology, physiology, cancer research, and cell biology.

Their research explores various topics such as epigenetics and DNA methylation, microRNA in disease regulation, muscle physiology and disorders, genetics, aging and longevity in model organisms, RNA research and splicing, extracellular vesicles in disease, and RNA modifications related to cancer.

Jonathan D. Wren has published numerous scientific papers, including recent works that address aging, mitochondrial protection, vascular rejuvenation, and cancer biology. Notable recent papers include:

  • "Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects" (2020, GeroScience)
  • "Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood" (2020, GeroScience)
  • "Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging" (2021, Aging Cell)
  • "Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study" (2020, The American Journal of Human Genetics)
  • "Micro RNA -195 controls MICU 1 expression and tumor growth in ovarian cancer" (2020, EMBO Reports)

The scientist often collaborates with other researchers, with frequent coauthors including Constantin Georgescu, Willard M. Freeman, Cory B. Giles, Subramaniyan Bharathiraja, and Matthew S. Walters.

Jonathan D. Wren's work has been published mainly in venues such as BioRxiv (Cold Spring Harbor Laboratory), GeroScience, The FASEB Journal, Cancer Research, and Aging Cell.

Best Publications

  • The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

    Yi-Yi Zhu;Tamara Tchkonia;Tamar Pirtskhalava;Adam C Gower

  • Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.

    Yi Zhu;Tamara Tchkonia;Heike Fuhrmann-Stroissnigg;Haiming M. Dai

  • Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome.

    Christopher J. Lessard;Christopher J. Lessard;He Li;He Li;Indra Adrianto;John A. Ice

  • Bioimage informatics

    Hanchuan Peng;Alex Bateman;Alfonso Valencia;Jonathan D. Wren

  • Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

    Zoltan Ungvari;Stefano Tarantini;Stefano Tarantini;Tamas Kiss;Tamas Kiss;Jonathan D. Wren;Jonathan D. Wren

  • Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients

    Patrick Coit;Matlock Jeffries;Nezam Altorok;Mikhail G. Dozmorov

  • The role of DNA methylation in epigenetics of aging.

    Archana Unnikrishnan;Willard M. Freeman;Jordan Jackson;Jonathan D. Wren

  • Knowledge discovery by automated identification and ranking of implicit relationships

    Jonathan D. Wren;Raffi Bekeredjian;Jelena A. Stewart;Ralph V. Shohet

  • Computer program products, systems and methods for information discovery and relational analyses

    Harold R. Garner;Jonathan D. Wren

  • High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry

    Celi Sun;Julio E. Molineros;Loren L. Looger;Xu Jie Zhou

  • The write position. A survey of perceived contributions to papers based on byline position and number of authors

    Jonathan D. Wren;Katarzyna Z. Kozak;Kathryn R. Johnson;Sara J. Deakyne

  • Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus

    Matlock A. Jeffries;Mikhail Dozmorov;Yuhong Tang;Joan T. Merrill

  • Plant virus biodiversity and ecology.

    Jonathan D Wren;Marilyn J Roossinck;Richard S Nelson;Kay Scheets

  • Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.

    Anna Csiszar;Tripti Gautam;Danuta Sosnowska;Stefano Tarantini

  • Aging Exacerbates Obesity-induced Cerebromicrovascular Rarefaction, Neurovascular Uncoupling, and Cognitive Decline in Mice

    Zsuzsanna Tucsek;Peter Toth;Stefano Tarantini;Danuta Sosnowska

  • Repeat Polymorphisms within Gene Regions: Phenotypic and Evolutionary Implications

    Jonathan D. Wren;Eva Forgacs;John W. Fondon;Alexander Pertsemlidis

  • Ska3 Is Required for Spindle Checkpoint Silencing and the Maintenance of Chromosome Cohesion in Mitosis

    John R. Daum;Jonathan D. Wren;Jeremy J. Daniel;Sushama Sivakumar

  • Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils

    Patrick Coit;Srilakshmi Yalavarthi;Mikhail Ognenovski;Wenpu Zhao

  • PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity

    Tomoaki Iwayama;Cameron Steele;Longbiao Yao;Mikhail G. Dozmorov;Mikhail G. Dozmorov

  • Clustering microarray-derived gene lists through implicit literature relationships

    Mark F. Burkart;Jonathan D. Wren;Jason I. Herschkowitz;Charles M. Perou

Frequent Co-Authors

Anna Csiszar
Anna Csiszar University of Oklahoma Health Sciences Center
Amr H. Sawalha
Amr H. Sawalha University of Pittsburgh
Zoltan Ungvari
Zoltan Ungvari University of Oklahoma Health Sciences Center
Arlan Richardson
Arlan Richardson University of Oklahoma Health Sciences Center
William E. Sonntag
William E. Sonntag University of Oklahoma Health Sciences Center
Holly Van Remmen
Holly Van Remmen Oklahoma Medical Research Foundation
Judith A. James
Judith A. James Oklahoma Medical Research Foundation
John B. Harley
John B. Harley United States Department of Veterans Affairs
Joan T. Merrill
Joan T. Merrill Oklahoma Medical Research Foundation
Gary J. Gorbsky
Gary J. Gorbsky Oklahoma Medical Research Foundation

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