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Biology and Biochemistry

D-Index
55
Citations
10770
World Ranking
15070
National Ranking
6306

Overview

Gary J. Gorbsky is a researcher affiliated with the Oklahoma Medical Research Foundation in the United States. Their work is situated primarily within the field of Biochemistry, Genetics, and Molecular Biology, with a strong concentration in Molecular Biology, Cell Biology, and Genetics. They have contributed to multiple subfields, including Plant Science and Oncology.

The researcher's published work spans a variety of topics related to cellular and molecular mechanisms. Key areas of focus include Microtubule and mitosis dynamics, Pluripotent Stem Cells Research, CRISPR and Genetic Engineering, Animal Genetics and Reproduction, Chromosomal and Genetic Variations, Genomics and Chromatin Dynamics, and DNA Repair Mechanisms.

Frequent collaborators in their research include John R. Daum, Casey O. DuBose, Hem Sapkota, Jonathan D. Wren, and Aaron R. Tipton.

Gary J. Gorbsky has published in several scientific venues, most notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Cell Science
  • Genes
  • Oncoscience
  • The Journal of Cell Biology

Selected recent publications by Gary J. Gorbsky cover topics such as mitotic spindle dynamics, centrosome integrity, and the development of immortal cell lines. These include:

  • "Dynamic Features of Chromosomal Instability during Culture of Induced Pluripotent Stem Cells," 2022, Genes
  • "CSAG1 maintains the integrity of the mitotic centrosome in cells with defective p53," 2020, Journal of Cell Science
  • "More than two populations of microtubules comprise the dynamic mitotic spindle," 2021, Journal of Cell Science
  • "VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro," 2021, Oncoscience
  • "Developing immortal cell lines from Xenopus embryos, four novel cell lines derived from Xenopus tropicalis," 2022, Open Biology

Best Publications

  • Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis

    Fangwei Wang;Jun Dai;John R. Daum;Ewa Niedzialkowska

  • Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint.

    R B Nicklas;S C Ward;G J Gorbsky

  • Regulation of microtubule stability and mitotic progression by survivin.

    Alessandra Giodini;Marko J. Kallio;Nathan R. Wall;Gary J. Gorbsky

  • Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis.

    Marko J. Kallio;Mark L. McCleland;P.Todd Stukenberg;Gary J. Gorbsky

  • Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends.

    Gary J. Gorbsky;Paul J. Sammak;Gary G. Borisy

  • Mammalian p55CDC Mediates Association of the Spindle Checkpoint Protein Mad2 with the Cyclosome/Anaphase-promoting Complex, and is Involved in Regulating Anaphase Onset and Late Mitotic Events

    Marko Kallio;Jasminder Weinstein;John R. Daum;Daniel J. Burke

  • Differential expression of a phosphoepitope at the kinetochores of moving chromosomes

    Gary J. Gorbsky;William A. Ricketts

  • The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity

    Mark L. McCleland;Richard D. Gardner;Marko J. Kallio;John R. Daum

  • Microinjection of Antibody to Mad2 Protein into Mammalian Cells in Mitosis Induces Premature Anaphase

    Gary J. Gorbsky;Rey Huei Chen;Andrew W. Murray

  • Spatiotemporal regulation of the anaphase-promoting complex in mitosis

    Sushama Sivakumar;Gary J. Gorbsky

  • The Reversibility of Mitotic Exit in Vertebrate Cells

    Tamara A. Potapova;John R. Daum;Bradley D. Pittman;Joanna R. Hudson

  • Isolation of the intercellular glycoproteins of desmosomes.

    G Gorbsky;M S Steinberg

  • Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E

    Maja Zecevic;Andrew D. Catling;Scott T. Eblen;Luigina Renzi

  • DNA topoisomerase II alpha is the major chromosome protein recognized by the mitotic phosphoprotein antibody MPM-2

    Salme Taagepera;Potu N. Rao;Fred H. Drake;Gary J. Gorbsky

  • Polo-like Kinase 1 Creates the Tension-Sensing 3F3/2 Phosphoepitope and Modulates the Association of Spindle-Checkpoint Proteins at Kinetochores

    Leena J. Ahonen;Marko J. Kallio;Marko J. Kallio;John R. Daum;Margaret Bolton

  • The Vertebrate Ndc80 Complex Contains Spc24 and Spc25 Homologs, which Are Required to Establish and Maintain Kinetochore-Microtubule Attachment

    Mark L. McCleland;Marko J. Kallio;Gregory A. Barrett-Wilt;Cortney A. Kestner

  • The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis

    Tamara Potapova;Gary J. Gorbsky

  • Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited

    Tamara A. Potapova;Sushama Sivakumar;Jennifer N. Flynn;Rong Li

  • Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells

    Marko J. Kallio;Victoria A. Beardmore;Jasminder Weinstein;Gary J. Gorbsky

  • Ska3 Is Required for Spindle Checkpoint Silencing and the Maintenance of Chromosome Cohesion in Mitosis

    John R. Daum;Jonathan D. Wren;Jeremy J. Daniel;Sushama Sivakumar

Frequent Co-Authors

P. Todd Stukenberg
P. Todd Stukenberg University of Virginia
Gary G. Borisy
Gary G. Borisy ADA Forsyth Institute
Malcolm S. Steinberg
Malcolm S. Steinberg Princeton University
Jonathan D. Wren
Jonathan D. Wren Oklahoma Medical Research Foundation
Hiroshi Yamada
Hiroshi Yamada Okayama University
Andrew W. Murray
Andrew W. Murray Harvard University
Stephen M. Cohen
Stephen M. Cohen University of Copenhagen
Hongtao Yu
Hongtao Yu The University of Texas Southwestern Medical Center
Olli Kallioniemi
Olli Kallioniemi Karolinska Institute
Chad A. Brautigam
Chad A. Brautigam The University of Texas Southwestern Medical Center

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