Tim J. Yen

Overview

Best Publications

• Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

  Valery Sudakin;Gordon K.T. Chan;Tim J. Yen

  1165
  Citations

• Interaction between ATM protein and c-Abl in response to DNA damage

  T Shafman;K K Khanna;P Kedar;K Spring

  618
  Citations

• Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC

  G.K.T. Chan;S.A. Jablonski;V. Sudakin;J.C. Hittle

  543
  Citations

• CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.

  H Liao;R J Winkfein;G Mack;J B Rattner

  522
  Citations

• CENP-E is a putative kinetochore motor that accumulates just before mitosis.

  Tim J. Yen;Gang Li;Bruce T. Schaar;Illya Szilak

  499
  Citations

• CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase.

  T J Yen;D A Compton;D Wise;R P Zinkowski

  473
  Citations

• Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin.

  Tim J. Yen;Paula S. Machlin;Don W. Cleveland

  424
  Citations

• CENP-E Function at Kinetochores Is Essential for Chromosome Alignment

  B. T. Schaar;G. K T Chan;Paul Samuel Maddox;Edward D Salmon

  401
  Citations

• Protein architecture of the human kinetochore microtubule attachment site.

  Xiaohu Wan;Ryan P. O'Quinn;Heather L. Pierce;Ajit P. Joglekar

  396
  Citations

• Microtubule-dependent Changes in Assembly of Microtubule Motor Proteins and Mitotic Spindle Checkpoint Proteins at PtK1 Kinetochores

  David B. Hoffman;Chad G. Pearson;Tim J. Yen;Bonnie J. Howell

  392
  Citations

• CHARACTERIZATION OF THE KINETOCHORE BINDING DOMAIN OF CENP-E REVEALS INTERACTIONS WITH THE KINETOCHORE PROTEINS CENP-F AND HBUBR1

  G.K.T. Chan;B.T. Schaar;T.J. Yen

  369
  Citations

• Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A.

  Aaron A. Van Hooser;Aaron A. Van Hooser;Ilia I. Ouspenski;Ilia I. Ouspenski;Heather C. Gregson;Heather C. Gregson;Daniel A. Starr;Daniel A. Starr

  368
  Citations

• The RanGAP1-RanBP2 Complex Is Essential for Microtubule-Kinetochore Interactions In Vivo

  Jomon Joseph;Song-Tao Liu;Sandra A Jablonski;Tim J Yen

  332
  Citations

• CENP-E Is Essential for Reliable Bioriented Spindle Attachment, but Chromosome Alignment Can Be Achieved via Redundant Mechanisms in Mammalian Cells

  Bruce F. McEwen;Bruce F. McEwen;Gordon K.T. Chan;Beata Zubrowski;Matthew S. Savoian;Matthew S. Savoian

  310
  Citations

• SUMO-2/3 Modification and Binding Regulate the Association of CENP-E with Kinetochores and Progression through Mitosis

  Xiang Dong Zhang;Jacqueline Goeres;Hong Zhang;Tim J. Yen

  293
  Citations

• Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro.

  V A Lombillo;C Nislow;T J Yen;V I Gelfand

  280
  Citations

• Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells

  Song-Tao Liu;Jerome B. Rattner;Sandra A. Jablonski;Tim J. Yen

  278
  Citations

• CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization.

  J. B. Rattner;A. Rao;M. J. Fritzler;D. W. Valencia

  272
  Citations

• Kinetochore structure and function

  Gordon K. Chan;Song-Tao Liu;Tim J. Yen

  267
  Citations

• Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.

  G. K. T. Chan;S. A. Jablonski;D. A. Starr;D. A. Starr;M. L. Goldberg

  261
  Citations