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Duane A. Compton

Duane A. Compton

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
15651
World Ranking
9127
National Ranking
4052

Overview

Duane A. Compton is affiliated with Dartmouth College in the United States and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology. Their research encompasses molecular and cell biology, focusing particularly on the dynamics of microtubules and mitosis.

The scientist's recent publications demonstrate a concentration on chromosome segregation, kinetochore-microtubule interactions, and cellular aging processes. Representative works include:

  • Small-molecule inhibition of aging-associated chromosomal instability delays cellular senescence, 2020, EMBO Reports
  • A comparative analysis of methods to measure kinetochore-microtubule attachment stability, 2020, Methods in Cell Biology
  • Small changes in phospho-occupancy at the kinetochore-microtubule interface drive mitotic fidelity, 2022, The Journal of Cell Biology
  • A pluripotent developmental state confers a low fidelity of chromosome segregation, 2023, Stem Cell Reports
  • Chromosome segregation fidelity is controlled by small changes in phospho-occupancy at the kinetochore-microtubule interface, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in their research include Thomas J. Kucharski, Kristina Godek, Martin R. Higgs, Jessica D. Warren, and Irma Vlasac. This collaborative work has been published primarily in venues such as bioRxiv, EMBO Reports, The Journal of Cell Biology, Stem Cell Reports, and Methods in Cell Biology.

They have contributed to an array of subfields, with primary research interests spread across molecular biology and cell biology. Additional subfields explored include plant science, physiology, and oncology.

The scientist's focus is evident in several investigative topics, notably:

  • Microtubule and mitosis dynamics
  • Photosynthetic processes and mechanisms
  • Genomics and chromatin dynamics
  • DNA repair mechanisms
  • Pluripotent stem cells research
  • Plant nutrient uptake and metabolism
  • Epigenetics and DNA methylation

This diverse engagement with both fundamental and applied aspects of cellular function and molecular mechanisms positions Duane A. Compton within an interdisciplinary intersection of life sciences, combining detailed cell biological analyses with broader molecular genetics themes.

Best Publications

  • Mechanisms of Chromosomal Instability

    Sarah L. Thompson;Samuel F. Bakhoum;Duane A. Compton

  • Examining the link between chromosomal instability and aneuploidy in human cells

    Sarah L. Thompson;Duane A. Compton

  • Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

    Sarah L. Thompson;Duane A. Compton

  • Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

    Samuel F. Bakhoum;Sarah L. Thompson;Amity L. Manning;Duane A. Compton

  • CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase.

    T J Yen;D A Compton;D Wise;R P Zinkowski

  • Dynactin is required for microtubule anchoring at centrosomes.

    N.J. Quintyne;S.R. Gill;D.M. Eckley;C.L. Crego

  • Spindle Assembly in Animal Cells

    Duane A. Compton

  • Deviant kinetochore microtubule dynamics underlie chromosomal instability.

    Samuel F. Bakhoum;Giulio Genovese;Duane A. Compton

  • The Kinesin-Related Protein, Hset, Opposes the Activity of Eg5 and Cross-Links Microtubules in the Mammalian Mitotic Spindle

    Vicki Mountain;Calvin Simerly;Louisa Howard;Asako Ando

  • Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.

    T Gaglio;A Saredi;J B Bingham;M J Hasbani

  • NuMA is required for the organization of microtubules into aster-like mitotic arrays.

    T Gaglio;A Saredi;D A Compton

  • Binding of matrix attachment regions to lamin polymers involves single-stranded regions and the minor groove.

    M. E. E. Luderus;J. L. Den Blaauwen;O. J. B. De Smit;D. A. Compton

  • Molecular Correlates of Primate Nuclear Transfer Failures

    Calvin Simerly;Tanja Dominko;Christopher Navara;Christopher Payne

  • Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes.

    Tirso Gaglio;Mary A Dionne;Duane A Duane A. Compton

  • Chromosome missegregation in human cells arises through specific types of kinetochore–microtubule attachment errors

    Sarah L. Thompson;Duane A. Compton

  • The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles

    Aime A. Levesque;Duane A. Compton

  • Chromosomal instability and cancer: a complex relationship with therapeutic potential

    Samuel F. Bakhoum;Duane A. Compton

  • Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis.

    D A Compton;I Szilak;D W Cleveland

  • NuMA is required for the proper completion of mitosis.

    Duane A. Compton;Don W. Cleveland

  • Minus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis.

    Alexey Khodjakov;Lily Copenagle;Michael B. Gordon;Duane A. Compton

Frequent Co-Authors

Helder Maiato
Helder Maiato University of Porto
Don W. Cleveland
Don W. Cleveland University of California, San Diego
Gerald Schatten
Gerald Schatten University of Pittsburgh
Tarun M. Kapoor
Tarun M. Kapoor Rockefeller University
Scott A. Gerber
Scott A. Gerber Dartmouth College
Alexey Khodjakov
Alexey Khodjakov New York State Department of Health
Sung Keun Kang
Sung Keun Kang Seoul National University
Miodrag Stojkovic
Miodrag Stojkovic University of Kragujevac
Steven R. Gill
Steven R. Gill University of Rochester Medical Center
Giulio Genovese
Giulio Genovese Broad Institute

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