World's Best Scientists 2026 revealed!
Claire E. Walczak

Claire E. Walczak

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
11713
World Ranking
18591
National Ranking
7599

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Claire E. Walczak is affiliated with Indiana University in the United States and has established a body of research primarily in the field of Biochemistry, Genetics, and Molecular Biology. Their work spans several subfields, notably Cell Biology, Molecular Biology, Condensed Matter Physics, Immunology and Allergy, as well as Cardiology and Cardiovascular Medicine.

The scientist's research topics focus heavily on microtubule and mitosis dynamics, cellular mechanics and interactions, and micro and nano robotics. Additional areas of study include cell adhesion molecules research, nuclear structure and function, ubiquitin and proteasome pathways, and cardiomyopathy and myosin studies.

Frequent collaboration has been a hallmark of their research career. Regular co-authors include Stephanie C. Ems-McClung, Stefan Husted, Jay Pilrose, Richard L. Carpenter, and Mark Hazelbaker.

Claire E. Walczak has contributed extensively to both journals and preprint repositories. Their publications appear notably in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Biology of the Cell
  • Cancers
  • Soft Matter
  • Cytoskeleton

Examples of recent publications include:

  • "Spatial regulation of MCAK promotes cell polarization and focal adhesion turnover to drive robust cell migration" (2021), Molecular Biology of the Cell
  • "MCAK Inhibitors Induce Aneuploidy in Triple-Negative Breast Cancer Models" (2023), Cancers
  • "Importin α/β promote Kif18B microtubule association and enhance microtubule destabilization activity" (2023), Molecular Biology of the Cell
  • "Switch-1 instability at the active site decouples ATP hydrolysis from force generation in myosin II" (2020), Cytoskeleton
  • "Structure and dynamics of motor-driven microtubule bundles" (2024), Soft Matter

In recognition of their scientific contributions, Claire E. Walczak was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2018.

Best Publications

  • A standardized kinesin nomenclature.

    Carolyn J. Lawrence;R. Kelly Dawe;Karen R. Christie;Don W. Cleveland

  • Kin I Kinesins Are Microtubule-Destabilizing Enzymes

    Arshad Desai;Suzie Verma;Timothy J. Mitchison;Claire E. Walczak

  • XKCM1: A Xenopus Kinesin-Related Protein That Regulates Microtubule Dynamics during Mitotic Spindle Assembly

    Claire E Walczak;Timothy J Mitchison;Arshad Desai

  • Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity

    Weijie Lan;Xin Zhang;Susan L Kline-Smith;Sara E Rosasco

  • A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity

    Claire E. Walczak;Isabelle Vernos;Timothy J. Mitchison;Eric Karsenti

  • Mechanisms of mitotic spindle assembly and function.

    Claire E Walczak;Rebecca Heald

  • Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts

    Régis Tournebize;Andrei Popov;Kazuhisa Kinoshita;Anthony J. Ashford

  • Mitotic spindle assembly and chromosome segregation: refocusing on microtubule dynamics.

    Susan L Kline-Smith;Claire E Walczak

  • The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles

    David J. Sharp;Kent L. McDonald;Heather M. Brown;Heinrich J. Matthies

  • Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase

    Gregory C. Rogers;Stephen L. Rogers;Tamara A. Schwimmer;Stephanie C. Ems-McClung

  • Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments.

    Susan L. Kline-Smith;Alexey Khodjakov;Polla Hergert;Claire E. Walczak

  • The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro.

    Arshad Desai;Andrew Murray;Timothy J. Mitchison;Claire E. Walczak

  • Mechanisms of chromosome behaviour during mitosis.

    Claire E. Walczak;Shang Cai;Alexey Khodjakov

  • Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities.

    Andrew Wilde;Andrew Wilde;Sofia B. Lizarraga;Sofia B. Lizarraga;Lijun Zhang;Christiane Wiese

  • Microtubule dynamics and tubulin interacting proteins.

    Claire E Walczak

  • Kinesin-14 Family Proteins HSET/XCTK2 Control Spindle Length by Cross-Linking and Sliding Microtubules

    Shang Cai;Lesley N. Weaver;Stephanie C. Ems-McClung;Claire E. Walczak

  • The Microtubule-Destabilizing Kinesin XKCM1 Regulates Microtubule Dynamic Instability in Cells

    Susan L. Kline-Smith;Claire E. Walczak

  • XCTK2: A Kinesin-related Protein That Promotes Mitotic Spindle Assembly in Xenopus laevis Egg Extracts

    Claire E. Walczak;Suzie Verma;Timothy J. Mitchison

  • Microtubule-depolymerizing kinesins.

    Claire E. Walczak;Sophia Gayek;Ryoma Ohi

  • Kinesin 13s in Mitosis: Key Players in the Spatial and Temporal Organization of Spindle Microtubules

    Stephanie C. Ems-McClung;Claire E. Walczak

Frequent Co-Authors

Timothy J. Mitchison
Timothy J. Mitchison Harvard University
Arshad Desai
Arshad Desai University of California, San Diego
Yixian Zheng
Yixian Zheng Carnegie Institution for Science
Michael Shelley
Michael Shelley Courant Institute of Mathematical Sciences
Rebecca Heald
Rebecca Heald University of California, Berkeley
Eric Karsenti
Eric Karsenti École Normale Supérieure
Ronald D. Vale
Ronald D. Vale University of California, San Francisco
Jonathan M. Scholey
Jonathan M. Scholey University of California, Davis
Alexey Khodjakov
Alexey Khodjakov New York State Department of Health
Huntington Potter
Huntington Potter University of Colorado Anschutz Medical Campus

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