Alfonso Bellacosa

Overview

Best Publications

• Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways.

  Lionel Larue;Alfonso Bellacosa

  1487
  Citations

• The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

  Scott G. Kennedy;Andrew J. Wagner;Suzanne D. Conzen;Joaquin Jordan

  1373
  Citations

• A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

  A Bellacosa;Testa;SP Staal;PN Tsichlis

  1345
  Citations

• AKT plays a central role in tumorigenesis.

  Joseph R. Testa;Alfonso Bellacosa

  1323
  Citations

• Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas.

  A. Bellacosa;D. De Feo;A. K. Godwin;D. W. Bell

  1154
  Citations

• Activation of AKT kinases in cancer: implications for therapeutic targeting.

  Alfonso Bellacosa;C. Chandra Kumar;Antonio Di Cristofano;Joseph Robert Testa

  1028
  Citations

• AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

  Jin Quan Cheng;Andrew K. Godwin;Alfonso Bellacosa;Takahiro Taguchi

  992
  Citations

• Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.

  Salvatore Cortellino;Jinfei Xu;Mara Sannai;Robert Moore

  943
  Citations

• Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27 Kip1 by PKB/Akt-mediated phosphorylation in breast cancer

  Giuseppe Viglietto;Maria Letizia Motti;Paola Bruni;Rosa Marina Melillo

  910
  Citations

• The Protein Kinase Akt Induces Epithelial Mesenchymal Transition and Promotes Enhanced Motility and Invasiveness of Squamous Cell Carcinoma Lines

  Sylvia Julien Grille;Alfonso Bellacosa;John Upson;Andres J. Klein-Szanto

  846
  Citations

• Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

  Tomasz Skorski;Alfonso Bellacosa;Margaret Nieborowska‐Skorska;Miroslaw Majewski

  793
  Citations

• Akt activation by growth factors is a multiple-step process: the role of the PH domain.

  Alfonso Bellacosa;Tung O Chan;Naheed N Ahmed;Ketaki Datta

  732
  Citations

• Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway *

  Robin C. Muise-Helmericks;H. Leighton Grimes;Alfonso Bellacosa;Scott E. Malstrom

  676
  Citations

• Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice.

  Gianluigi Condorelli;Alessandra Drusco;Giorgio Stassi;Alfonso Bellacosa

  570
  Citations

• Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition.

  S. Julien;I. Puig;E. Caretti;J. Bonaventure

  541
  Citations

• Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.

  Hwai Wen Chang;Masahiro Aoki;David Fruman;Kurt R. Auger

  540
  Citations

• Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways

  Guang-Hui Xiao;Michael Jeffers;Alfonso Bellacosa;Yasuhiro Mitsuuchi

  509
  Citations

• The Akt kinase: Molecular determinants of oncogenicity

  Masahiro Aoki;Osvaldo Batista;Alfonso Bellacosa;Philip Tsichlis

  406
  Citations

• Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase ACTIVATION BY GROWTH FACTORS, v-src and v-Ha-ras, IN Sf9 AND MAMMALIAN CELLS

  Ketaki Datta;Alfonso Bellacosa;Tung O. Chan;Philip N. Tsichlis

  391
  Citations

• MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1.

  Alfonso Bellacosa;Lucia Cicchillitti;Filippo Schepis;Antonio Riccio

  328
  Citations