World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
8905
World Ranking
18007
National Ranking
576

Overview

Alessandra Viel is affiliated with the Centro di Riferimento Oncologico in Italy and has a research focus spanning multiple areas within medicine, biochemistry, genetics, and molecular biology. Their work is heavily concentrated on understanding genetic factors related to cancer, particularly colorectal cancer and breast cancer associated with BRCA gene mutations.

Their scholarly output includes several papers published in peer-reviewed journals, addressing various aspects of cancer genetics and molecular oncology. Notable recent publications include:

  • "Hereditary Cancer Syndromes: A Comprehensive Review with a Visual Tool," 2023, Genes
  • "Pregnancy After Breast Cancer in Young BRCA Carriers," 2023, JAMA
  • "MLH1 Promoter Methylation Could Be the Second Hit in Lynch Syndrome Carcinogenesis," 2023, Genes
  • "Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction," 2020, UNC Libraries
  • "Male breast cancer risk associated with pathogenic variants in genes other than BRCA1/2: an Italian case-control study," 2023, European Journal of Cancer

The scientist has collaborated frequently with several coauthors, including Maria Grazia Tibiletti, Fabio Puglisi, Giulia Cini, Paolo Radice, and Maurizio Ponz de Leòn. These collaborations have contributed to advancing knowledge within their shared fields of study.

Their publications are predominantly featured in the journal Genes, alongside other venues such as Digestive and Liver Disease, JAMA, UNC Libraries, and the European Journal of Cancer. This reflects a focus on genetics and oncology research published through diverse scientific outlets.

Their main fields of study are:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these disciplines, the scientist works extensively in the following subfields:

  • Genetics
  • Pathology and Forensic Medicine
  • Molecular Biology
  • Oncology
  • Cancer Research

The principal research topics covered in their work include:

  • Genetic factors in colorectal cancer
  • BRCA gene mutations in cancer
  • Cancer Genomics and Diagnostics
  • Genomics and Rare Diseases
  • Colorectal Cancer Screening and Detection
  • DNA Repair Mechanisms
  • Male Breast Health Studies

Best Publications

  • High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability.

    Riccardo Dolcetti;Alessandra Viel;Claudio Doglioni;Antonio Russo

  • Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

    Bryony A Thompson;Bryony A Thompson;Amanda B Spurdle;John-Paul Plazzer;Marc S Greenblatt

  • A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

    Antonis C. Antoniou;Xianshu Wang;Zachary S. Fredericksen;Lesley McGuffog

  • Microsatellite Instability and High Content of Activated Cytotoxic Lymphocytes Identify Colon Cancer Patients with a Favorable Prognosis

    Massimo Guidoboni;Roberta Gafà;Alessandra Viel;Claudio Doglioni

  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Roger L Milne;Roger L Milne;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Kyriaki Michailidou;Kyriaki Michailidou;Jonathan Beesley

  • Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

    Fergus J. Couch;Xianshu Wang;Lesley McGuffog;Andrew Lee

  • Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

    Antonis C. Antoniou;Jonathan Beesley;Lesley McGuffog;Olga M. Sinilnikova

  • Prevalence of the Y165C, G382D and 1395delGGA germline mutations of the MYH gene in Italian patients with adenomatous polyposis coli and colorectal adenomas.

    Viviana Gismondi;Maurizio Meta;Luigina Bonelli;Paolo Radice

  • Human MRE11 is inactivated in mismatch repair‐deficient cancers

    Giuseppe Giannini;Elisabetta Ristori;Fabio Cerignoli;Christian Rinaldi

  • The Italian multi-centre project on evaluation of MRI and other imaging modalities in early detection of breast cancer in subjects at high genetic risk.

    Podo F;Sardanelli F;Canese R;D'Agnolo G

  • A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer

    Alessandra Viel;Alessandro Bruselles;Ettore Meccia;Mara Fornasarig

  • Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.

    Christopher A. Maxwell;Javier Benitez;Laia Gomez-Baldo;Ana Osorio

  • Prediction of breast and prostate cancer risks in male BRCA1 and BRCA2 mutation carriers using polygenic risk scores

    Julie Lecarpentier;Valentina Silvestri;Karoline B. Kuchenbaecker;Karoline B. Kuchenbaecker;Daniel Barrowdale

  • Cancer risk associated with STK11/LKB1 germline mutations in Peutz-Jeghers syndrome patients: Results of an Italian multicenter study

    Nicoletta Resta;Daniela Pierannunzio;Gennaro Mariano Lenato;Alessandro Stella

  • Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer

    Mia M. Gaudet;Tomas Kirchhoff;Todd Green;Joseph Vijai

  • Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers

    Antonis C. Antoniou;Olga M. Sinilnikova;Lesley McGuffog;Sue Healey

  • Molecular Screening for Hereditary Nonpolyposis Colorectal Cancer: A Prospective, Population-Based Study

    Antonio Percesepe;Francesca Borghi;Mirco Menigatti;Lorena Losi

  • Male breast cancer in BRCA1 and BRCA2 mutation carriers: Pathology data from the Consortium of Investigators of Modifiers of BRCA1/2

    Valentina Silvestri;Daniel Barrowdale;Anna Marie Mulligan;Anna Marie Mulligan;Susan L. Neuhausen

  • Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability

    Giuseppe Giannini;Christian Rinaldi;Elisabetta Ristori;Maria Irene Ambrosini

  • Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants : An ENIGMA resource to support clinical variant classification

    Michael T. Parsons;Emma Tudini;Hongyan Li;Eric Hahnen

Frequent Co-Authors

Paolo Radice
Paolo Radice Fondazione IRCCS Istituto Nazionale dei Tumori
Maurizio Genuardi
Maurizio Genuardi Catholic University of the Sacred Heart
Paolo Peterlongo
Paolo Peterlongo Memorial Sloan Kettering Cancer Center
Marco Montagna
Marco Montagna Istituto Oncologico Veneto
Irene L. Andrulis
Irene L. Andrulis University of Toronto
Esther M. John
Esther M. John Stanford University
Katherine L. Nathanson
Katherine L. Nathanson University of Pennsylvania
Heli Nevanlinna
Heli Nevanlinna University of Helsinki
Fergus J. Couch
Fergus J. Couch Mayo Clinic

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