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Molecular Biology

D-Index
53
Citations
8628
World Ranking
2397
National Ranking
37

Overview

Ruben Pio is affiliated with the University of Navarra in Spain and has made significant contributions to the fields of medicine, immunology, and molecular biology. Their research is primarily focused on cancer, with a particular emphasis on lung cancer treatments and mutations, immune system interactions in cancer, and cancer immunotherapy.

Their main fields of study include:

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Within these broader fields, they have specialized subfields of research that include:

  • Immunology
  • Oncology
  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Themes central to Ruben Pio's work cover diverse topics such as:

  • Lung Cancer Treatments and Mutations
  • Complement system in diseases
  • Immune cells in cancer
  • Cancer Immunotherapy and Biomarkers
  • Cancer Genomics and Diagnostics
  • Immune Cell Function and Interaction
  • RNA modifications and cancer

Ruben Pio has published in multiple journals with a notable presence in venues such as:

  • Annals of Oncology
  • Immunobiology
  • Cancers
  • Frontiers in Immunology
  • Cancer Letters

Frequent co-authors in Ruben Pio's publications include:

  • Daniel Ajona
  • Luis M. Montuenga
  • Yaiza Senent
  • Alfonso Calvo
  • Ana Remírez

Representative publications from Ruben Pio's recent body of work include:

  • "Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade," 2020, Nature Cancer
  • "Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis," 2021, Cancer Letters
  • "SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation," 2021, Journal for ImmunoTherapy of Cancer
  • "Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death," 2020, Cancer Discovery
  • "Genome-wide profiling of non-smoking-related lung cancer cells reveals common RB1 rearrangements associated with histopathologic transformation in EGFR-mutant tumors," 2020, Annals of Oncology

Best Publications

  • Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges

    Luis M. Seijo;Nir Peled;Daniel Ajona;Mattia Boeri

  • Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.

    Mercedes Garayoa;Alfredo Martínez;Sunmin Lee;Rubén Pío

  • Alternative splicing: an emerging topic in molecular and clinical oncology

    María J Pajares;Teresa Ezponda;Raúl Catena;Alfonso Calvo

  • Complement Factor H Is a Serum-binding Protein for Adrenomedullin, and the Resulting Complex Modulates the Bioactivities of Both Partners

    Rubén Pı́o;Alfredo Martı́nez;Edward J. Unsworth;Jeffrey A. Kowalak

  • Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression.

    Leticia Corrales;Daniel Ajona;Stavros Rafail;Juan J. Lasarte

  • Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines.

    Pedro P. Medina;Octavio A. Romero;Takashi Kohno;Luis M. Montuenga

  • A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis

    Daniel Ajona;Sergio Ortiz-Espinosa;Haritz Moreno;Teresa Lozano

  • The Role of Complement in Tumor Growth

    Ruben Pio;Leticia Corrales;John D. Lambris

  • Altered patterns of expression of members of the heterogeneous nuclear ribonucleoprotein (hnRNP) family in lung cancer

    Irene Pino;Rubén Pı́o;Gemma Toledo;Natalia Zabalegui

  • Complementing the Cancer-Immunity Cycle.

    Ruben Pio;Daniel Ajona;Sergio Ortiz-Espinosa;Alberto Mantovani

  • The Effects of Adrenomedullin Overexpression in Breast Tumor Cells

    Alfredo Martínez;Michele Vos;Liliana Guédez;Gurmeet Kaur

  • Complement inhibition in cancer therapy.

    Ruben Pio;Daniel Ajona;John D. Lambris

  • A gene-alteration profile of human lung cancer cell lines†

    Raquel Blanco;Reika Iwakawa;Moying Tang;Takashi Kohno

  • Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene

    Julian Carretero;Pedro P Medina;Ruben Pio;Luis M Montuenga

  • Investigation of Complement Activation Product C4d as a Diagnostic and Prognostic Biomarker for Lung Cancer

    Daniel Ajona;María J. Pajares;Leticia Corrales;Jose L. Perez-Gracia

  • Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement.

    Daniel Ajona;Zafira Castaño;Mercedes Garayoa;Enrique Zudaire

  • Down-regulation of human complement factor H sensitizes non-small cell lung cancer cells to complement attack and reduces in vivo tumor growth.

    Daniel Ajona;Yi-Fan Hsu;Leticia Corrales;Luis M. Montuenga

  • Molecular Analysis of a Multistep Lung Cancer Model Induced by Chronic Inflammation Reveals Epigenetic Regulation of p16 and Activation of the DNA Damage Response Pathway

    David Blanco;Silvestre Vicent;Silvestre Vicent;Mario F. Fraga;Ignacio Fernandez-Garcia;Ignacio Fernandez-Garcia

  • A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer.

    Angel Diaz-Lagares;Jesus Mendez-Gonzalez;David Hervas;Maria Saigi

  • Innate immune mediators in cancer: between defense and resistance.

    Pedro Berraondo;Luna Minute;Daniel Ajona;Daniel Ajona;Leticia Corrales

Frequent Co-Authors

Luis M. Montuenga
Luis M. Montuenga University of Navarra
Frank Cuttitta
Frank Cuttitta National Institutes of Health
Carmen Behrens
Carmen Behrens The University of Texas MD Anderson Cancer Center
Ignacio I. Wistuba
Ignacio I. Wistuba The University of Texas MD Anderson Cancer Center
Ignacio Melero
Ignacio Melero University of Oxford
Tom Eirik Mollnes
Tom Eirik Mollnes Oslo University Hospital
John D. Lambris
John D. Lambris University of Pennsylvania
Anna M. Blom
Anna M. Blom Lund University
Juan José Lasarte
Juan José Lasarte University of Navarra
Manel Esteller
Manel Esteller Josep Carreras Leukaemia Research Institute

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