World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
26984
World Ranking
10520
National Ranking
4565

Overview

Charles W. M. Roberts is affiliated with St. Jude Children's Research Hospital in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Pathology and Forensic Medicine, Immunology, Public Health, Environmental and Occupational Health, and Pediatrics, Perinatology and Child Health.

The main topics addressed in Roberts' work include Chromatin Remodeling and Cancer, Cancer Mechanisms and Therapy, Protein Degradation and Inhibitors, Childhood Cancer Survivors' Quality of Life, Neuroblastoma Research and Treatments, Acute Lymphoblastic Leukemia research, and CAR-T cell therapy research.

Roberts has contributed to several papers published in high-profile scientific journals. Notable recent publications include:

  • The SWI/SNF complex in cancer - biology, biomarkers and therapy, 2020, Nature Reviews Clinical Oncology
  • A first-generation pediatric cancer dependency map, 2021, Nature Genetics
  • cBAF complex components and MYC cooperate early in CD8+ T cell fate, 2022, Nature
  • Mitotic bookmarking by SWI/SNF subunits, 2023, Nature
  • Chromatin remodellers as therapeutic targets, 2024, Nature Reviews Drug Discovery

The scientist frequently publishes in the following venues:

  • Nature
  • Nature Genetics
  • Molecular Cell
  • Nature reviews. Cancer
  • UNC Libraries

Collaboration is a significant aspect of Roberts' research efforts. Frequent co-authors include:

  • Zhexin Zhu
  • Janet F. Partridge
  • Shondra M. Pruett-Miller
  • Sandi Radko-Juettner
  • Jacquelyn A. Myers

Best Publications

  • Mutational heterogeneity in cancer and the search for new cancer-associated genes

    Michael S. Lawrence;Petar Stojanov;Petar Stojanov;Paz Polak;Paz Polak;Paz Polak;Gregory V. Kryukov;Gregory V. Kryukov;Gregory V. Kryukov

  • SWI/SNF nucleosome remodellers and cancer

    Boris G. Wilson;Charles W. M. Roberts

  • Targeting EZH2 in cancer

    Kimberly H Kim;Charles W M Roberts

  • Toward understanding and exploiting tumor heterogeneity

    Ash A Alizadeh;Victoria Aranda;Alberto Bardelli;Cedric Blanpain

  • Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

    Boris G. Wilson;Xi Wang;Xiaohua Shen;Elizabeth S. McKenna

  • Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

    Andrew J Aguirre;Robin M Meyers;Barbara A. Weir;Francisca Vázquez

  • Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

    Charles W. M. Roberts;Shelly A. Galusha;Máirín E. McMenamin;Christopher D. M. Fletcher

  • Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia.

    Masahiko Hatano;Charles W. M. Roberts;Mark Minden;William M. Crist

  • ARID1A Mutations in Cancer: Another Epigenetic Tumor Suppressor?

    Jennifer N. Wu;Charles W.M. Roberts

  • Mutational processes shape the landscape of TP53 mutations in human cancer

    Andrew O. Giacomelli;Andrew O. Giacomelli;Xiaoping Yang;Robert E. Lintner;James M. McFarland

  • Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

    Jennifer A. Perry;Adam Kiezun;Peter Tonzi;Eliezer M. Van Allen;Eliezer M. Van Allen

  • A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers

    Ryan S. Lee;Chip Stewart;Scott L. Carter;Lauren Ambrogio

  • Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5

    Charles W.M Roberts;Monique M Leroux;Mark D Fleming;Stuart H Orkin

  • The SWI/SNF complex in cancer — biology, biomarkers and therapy

    Priya Mittal;Charles W. M. Roberts

  • ARID1B is a specific vulnerability in ARID1A-mutant cancers

    Katherine C Helming;Xiaofeng Wang;Boris G Wilson;Francisca Vazquez

  • Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

    Gregory R. Hoffman;Rami Rahal;Frank Buxton;Kay Xiang

  • Hox11 controls the genesis of the spleen.

    Charles W. M. Roberts;John R. Shutter;Stanley J. Korsmeyer

  • AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection

    Thomas Vierbuchen;Emi Ling;Christopher J. Cowley;Cameron H. Couch

  • ErratumEpigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

    Boris G. Wilson;Xi Wang;Xiaohua Shen;Elizabeth S. McKenna

  • Abstract A41: Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

    Adam Kiezun;Jennifer Perry;Peter Tonzi;Eliezer Van Allen

Frequent Co-Authors

William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Francisca Vazquez
Francisca Vazquez Broad Institute
Peter J. Park
Peter J. Park Harvard University
Todd R. Golub
Todd R. Golub Harvard University
Aviad Tsherniak
Aviad Tsherniak Broad Institute
Levi A. Garraway
Levi A. Garraway Roche (United States)
Stuart H. Orkin
Stuart H. Orkin Harvard University
Jaclyn A. Biegel
Jaclyn A. Biegel University of Southern California
David E. Root
David E. Root Broad Institute
Keith L. Ligon
Keith L. Ligon Harvard University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Charles W. M. Roberts

Trending Scientists

Recently Published Articles