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Biology and Biochemistry

D-Index
57
Citations
7755
World Ranking
14116
National Ranking
300

Overview

Pedro A. Lazo is affiliated with the University of Salamanca in Spain. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with a significant portion of their work concentrated in Molecular Biology, Genetics, Cell Biology, Oncology, and Cellular and Molecular Neuroscience.

Their scientific contributions cover several interconnected topics, including:

  • Nuclear Structure and Function
  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • Protein Degradation and Inhibitors
  • Neurogenetic and Muscular Disorders Research
  • Genomics and Rare Diseases
  • Genetics and Neurodevelopmental Disorders

Pedro A. Lazo has authored several research papers, notable among them are:

  • "The human VRK1 chromatin kinase in cancer biology," 2021, published in Cancer Letters
  • "VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage," 2020, published in Cancers
  • "VRK1 Depletion Facilitates the Synthetic Lethality of Temozolomide and Olaparib in Glioblastoma Cells," 2021, published in Frontiers in Cell and Developmental Biology
  • "The VRK1 chromatin kinase regulates the acetyltransferase activity of Tip60/KAT5 by sequential phosphorylations in response to DNA damage," 2022, published in Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  • "VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1," 2023, published in International Journal of Molecular Sciences

Their frequent coauthors include Elena Navarro-Carrasco, Patricia Morejón-García, Eva Monte-Serrano, Íñigo Marcos-Alcalde, and Paulino Gómez-Puertas. These collaborations reflect ongoing partnerships in producing research outputs.

Pedro A. Lazo's work has been published in various scientific journals, with recurring publications in:

  • International Journal of Molecular Sciences
  • Cancers
  • Frontiers in Cell and Developmental Biology
  • Cancer Letters
  • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • The molecular genetics of cervical carcinoma

    P A Lazo

  • Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation.

    S Barrena;J Almeida;M Yunta;A López

  • Tetraspanin proteins as organisers of membrane microdomains and signalling complexes.

    Mónica Yunta;Pedro A. Lazo

  • Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis.

    Belén Martı́n-Martı́n;Belén Martı́n-Martı́n;Svetlana M. Nabokina;Svetlana M. Nabokina;Juan Blasi;Juan Blasi;Pedro A. Lazo;Pedro A. Lazo

  • The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

    Susana Lopez-Borges;Pedro A Lazo;Pedro A Lazo

  • Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis.

    M Rodriguez-Paredes;A Martinez de Paz;L Simó-Riudalbas;S Sayols

  • p53 Stabilization and Accumulation Induced by Human Vaccinia-Related Kinase 1

    Francisco M. Vega;Ana Sevilla;Pedro A. Lazo

  • Functional implications of tetraspanin proteins in cancer biology

    Pedro A. Lazo

  • Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas

    Pedro A. Lazo;Jung S. Lee;Philip N. Tsichlis

  • Human Vaccinia-related Kinase 1 (VRK1) Activates the ATF2 Transcriptional Activity by Novel Phosphorylation on Thr-73 and Ser-62 and Cooperates with JNK

    Ana Sevilla;Claudio R. Santos;Francisco M. Vega;Pedro A. Lazo

  • The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer†

    Pedro P. Medina;Sandra D. Castillo;Sandra Blanco;Marta Sanz-Garcia

  • c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)

    Ana Sevilla;Claudio R Santos;Ramiro Barcia;Francisco M Vega

  • Amino Acids and Glucose Utilization by Different Metabolic Pathways in Ascites‐Tumour Cells

    Pedro A. Lazo

  • Human VRK1 is an early response gene and its loss causes a block in cell cycle progression.

    Alberto Valbuena;Inmaculada López-Sánchez;Pedro A. Lazo

  • Role of Vesicle-Associated Membrane Protein-2, Through Q-Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor/R-Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Interaction, in the Exocytosis of Specific and Tertiary Granules of Human Neutrophils

    Faustino Mollinedo;Belén Martín-Martín;Jero Calafat;Svetlana M. Nabokina

  • Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.

    C Anadón;S Guil;L Simó-Riudalbas;C Moutinho

Frequent Co-Authors

Philip N. Tsichlis
Philip N. Tsichlis The Ohio State University
Faustino Mollinedo
Faustino Mollinedo University of Salamanca
Evelina Gatti
Evelina Gatti Aix-Marseille University
Alberto Sols
Alberto Sols Spanish National Research Council
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Sergio Lavandero
Sergio Lavandero University of Chile
Alfonso Bellacosa
Alfonso Bellacosa Fox Chase Cancer Center
Leonidas C. Platanias
Leonidas C. Platanias Northwestern University
Hsing Jien Kung
Hsing Jien Kung Taipei Medical University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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