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Biology and Biochemistry

D-Index
104
Citations
42791
World Ranking
1245
National Ranking
735

Medicine

D-Index
105
Citations
42884
World Ranking
6743
National Ranking
3559

Overview

James A. McCubrey is affiliated with East Carolina University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad areas, McCubrey has focused extensively on Molecular Biology, Oncology, Infectious Diseases, Cell Biology, and Cancer Research.

Their work addresses various scientific topics, including:

  • Wnt/β-catenin signaling in development and cancer
  • Cancer-related Molecular Pathways
  • Epigenetics and DNA Methylation
  • PI3K/AKT/mTOR signaling in cancer
  • COVID-19 Clinical Research Studies
  • Hippo pathway signaling and YAP/TAZ
  • Pancreatic and Hepatic Oncology Research

Among recent publications, McCubrey has contributed to the following papers:

  • "Targeting GSK3 and Associated Signaling Pathways Involved in Cancer," published in 2020 in Cells
  • "The PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19," published in 2021 in Drug Discovery Today
  • "The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment," published in 2020 in Cells
  • "New landscapes and horizons in hepatocellular carcinoma therapy," published in 2020 in Aging
  • "Effects of TP53 Mutations and miRs on Immune Responses in the Tumor Microenvironment Important in Pancreatic Cancer Progression," published in 2022 in Cells

Frequent coauthors of McCubrey include:

  • Stefano Ratti
  • Lucio Cocco
  • Alberto M. Martelli
  • Melchiorre Cervello
  • Shaw M. Akula

McCubrey has published regularly in several academic venues. Notable among these are:

  • Advances in Biological Regulation
  • Cells
  • Aging
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • International Journal of Molecular Sciences

Best Publications

  • ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE

    James A. McCubrey;Linda S. Steelman;William H. Chappell;Stephen L. Abrams

  • Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy

    F Chang;J T Lee;P M Navolanic;L S Steelman

  • Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

    Marina Konopleva;Rooha Contractor;Twee Tsao;Ismael Samudio

  • Reactive oxygen species-induced activation of the MAP kinase signaling pathways.

    James A. McCubrey;Michelle M. LaHair;Richard A. Franklin

  • Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention

    F Chang;L S Steelman;J T Lee;J G Shelton

  • JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.

    L S Steelman;S C Pohnert;J G Shelton;Richard A Franklin

  • Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

    James A. McCubrey;Linda S. Steelman;Steven L. Abrams;John T. Lee

  • Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

    Linda S. Steelman;William H. Chappell;Stephen L. Abrams;C. Ruth Kempf

  • Transfer of specificity by murine alpha and beta T-cell receptor genes.

    Dembić Z;Haas W;Weiss S;McCubrey J

  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

    William H. Chappell;Linda S. Steelman;Jacquelyn M. Long;Ruth C. Kempf

  • Cutaneous melanoma: From pathogenesis to therapy (Review)

    Giulia C. Leonardi;Luca Falzone;Rossella Salemi;Antonino Zanghì

  • Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review)

    Fumin Chang;Linda S. Steelman;John G. Shelton;John T. Lee

  • GSK-3 as potential target for therapeutic intervention in cancer.

    James A. McCubrey;Linda S. Steelman;Fred E. Bertrand;Nicole Marie Davis

  • Senescence-Associated Exosome Release from Human Prostate Cancer Cells

    Brian D. Lehmann;Matthew S. Paine;Adam M. Brooks;James A. McCubrey

  • Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia

    L. S. Steelman;S. L. Abrams;J. Whelan;F. E. Bertrand

  • Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell lines

    Thomas M. Buttke;James A. McCubrey;Terence C. Owen

  • Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mtor cascades which alter therapy response

    James A McCubrey;Linda S Steelman;William H Chappell;Stephen L Abrams

  • The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia.

    JT Lee;JA McCubrey

  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

    James Andrew McCubrey;Linda S. Steelman;William H. Chappell;Stephen L. Abrams

  • Akt as a therapeutic target in cancer.

    Linda S Steelman;Kristin M Stadelman;William H Chappell;Stefan Horn

Frequent Co-Authors

Alberto M. Martelli
Alberto M. Martelli University of Bologna
Massimo Libra
Massimo Libra University of Catania
Lucio Cocco
Lucio Cocco University of Bologna
Richard A. Franklin
Richard A. Franklin East Carolina University
Giuseppe Montalto
Giuseppe Montalto University of Palermo
Melchiorre Cervello
Melchiorre Cervello National Research Council (CNR)
Michele Milella
Michele Milella University of Verona
Luca M. Neri
Luca M. Neri University of Ferrara
Marina Konopleva
Marina Konopleva The University of Texas MD Anderson Cancer Center
Martin McMahon
Martin McMahon Huntsman Cancer Institute

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