D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 79 Citations 27,950 318 World Ranking 1831 National Ranking 1037
Medicine D-index 85 Citations 27,471 325 World Ranking 7505 National Ranking 4106

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • Apoptosis

His primary scientific interests are in Cancer research, PI3K/AKT/mTOR pathway, Protein kinase B, Signal transduction and MAPK/ERK pathway. His work carried out in the field of Cancer research brings together such families of science as Leukemia, Immunology, Kinase and Cell growth. His PI3K/AKT/mTOR pathway research is multidisciplinary, incorporating perspectives in Carcinogenesis, Cancer, Targeted therapy and Wnt signaling pathway.

His research in Protein kinase B intersects with topics in Cancer stem cell, GSK-3 and PTEN. His Signal transduction study incorporates themes from Autocrine signalling and Phosphorylation. His MAPK/ERK pathway research incorporates themes from Protein phosphatase 2, Mitogen-activated protein kinase, Growth factor receptor and Apoptosis.

His most cited work include:

  • ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE (1529 citations)
  • Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy (842 citations)
  • Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia (819 citations)

What are the main themes of his work throughout his whole career to date?

James A. McCubrey focuses on Cancer research, PI3K/AKT/mTOR pathway, Protein kinase B, Signal transduction and Cell biology. His studies deal with areas such as Cancer, Targeted therapy, Cell growth, Apoptosis and MAPK/ERK pathway as well as Cancer research. His research on PI3K/AKT/mTOR pathway often connects related topics like Pharmacology.

His Protein kinase B study combines topics in areas such as Jurkat cells and Leukemia. The study incorporates disciplines such as Carcinogenesis, Endocrinology and Kinase, Protein kinase A in addition to Signal transduction. His biological study deals with issues like Cytokine, which deal with fields such as Autocrine signalling.

He most often published in these fields:

  • Cancer research (52.13%)
  • PI3K/AKT/mTOR pathway (34.83%)
  • Protein kinase B (32.36%)

What were the highlights of his more recent work (between 2015-2021)?

  • Cancer research (52.13%)
  • Cancer (15.96%)
  • PI3K/AKT/mTOR pathway (34.83%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Cancer research, Cancer, PI3K/AKT/mTOR pathway, Cell biology and Signal transduction. His Cancer research study integrates concerns from other disciplines, such as Pancreatic cancer, Cell growth, Cancer cell, Immunology and Targeted therapy. James A. McCubrey works mostly in the field of Cancer, limiting it down to concerns involving Disease and, occasionally, Pandemic, Severe acute respiratory syndrome coronavirus 2 and microRNA.

His PI3K/AKT/mTOR pathway research incorporates elements of Protein kinase B and MAPK/ERK pathway. His Protein kinase B study combines topics from a wide range of disciplines, such as Tyrosine kinase, Kinase, Drug discovery and Imatinib mesylate. The various areas that James A. McCubrey examines in his Cell biology study include Cell cycle, Cell and Cellular differentiation.

Between 2015 and 2021, his most popular works were:

  • Cutaneous melanoma: From pathogenesis to therapy (Review) (131 citations)
  • Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. (86 citations)
  • Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity—Diverse effects on cell growth, metabolism and cancer (85 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • Apoptosis

James A. McCubrey mainly investigates Cancer research, PI3K/AKT/mTOR pathway, Cancer, Protein kinase B and Immunology. His biological study spans a wide range of topics, including Cell growth, Tumor microenvironment, Cancer cell, Metastasis and Regulation of gene expression. His PI3K/AKT/mTOR pathway study frequently draws connections between related disciplines such as MAPK/ERK pathway.

Protein kinase B is the subject of his research, which falls under Cell biology. James A. McCubrey is interested in Signal transduction, which is a field of Cell biology. He works mostly in the field of Immunology, limiting it down to topics relating to Apoptosis and, in certain cases, Cell culture.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE

James A. McCubrey;Linda S. Steelman;William H. Chappell;Stephen L. Abrams.
Biochimica et Biophysica Acta (2007)

2357 Citations

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy

F Chang;J T Lee;P M Navolanic;L S Steelman.
Leukemia (2003)

1255 Citations

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

Marina Konopleva;Rooha Contractor;Twee Tsao;Ismael Samudio.
Cancer Cell (2006)

998 Citations

Reactive oxygen species-induced activation of the MAP kinase signaling pathways.

James A. McCubrey;Michelle M. LaHair;Richard A. Franklin.
Antioxidants & Redox Signaling (2006)

887 Citations

Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention

F Chang;L S Steelman;J T Lee;J G Shelton.
Leukemia (2003)

878 Citations

JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.

L S Steelman;S C Pohnert;J G Shelton;Richard A Franklin.
Leukemia (2004)

787 Citations

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

James A. McCubrey;Linda S. Steelman;Steven L. Abrams;John T. Lee.
Advances in Enzyme Regulation (2006)

767 Citations

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

Linda S. Steelman;William H. Chappell;Stephen L. Abrams;C. Ruth Kempf.
Aging (Albany NY) (2011)

654 Citations

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

William H. Chappell;Linda S. Steelman;Jacquelyn M. Long;Ruth C. Kempf.
Oncotarget (2011)

564 Citations

Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review)

Fumin Chang;Linda S. Steelman;John G. Shelton;John T. Lee.
International Journal of Oncology (2003)

508 Citations

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