What is he best known for?
The fields of study he is best known for:
- Gene
- Cancer
- Signal transduction
His main research concerns MAPK/ERK pathway, Signal transduction, Cell biology, Cancer research and PI3K/AKT/mTOR pathway.
His research in MAPK/ERK pathway is mostly concerned with Anti-apoptotic Ras signalling cascade.
Specifically, his work in Signal transduction is concerned with the study of Mitogen-activated protein kinase.
His Cell biology research integrates issues from Cell cycle and Receptor, Biochemistry.
Richard A. Franklin frequently studies issues relating to Protein kinase B and PI3K/AKT/mTOR pathway.
His work carried out in the field of PTEN brings together such families of science as Carcinogenesis, Protein phosphatase 2 and Targeted therapy.
His most cited work include:
- ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE (1529 citations)
- Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy (842 citations)
- Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention (570 citations)
What are the main themes of his work throughout his whole career to date?
Richard A. Franklin mainly investigates Cell biology, Cancer research, Signal transduction, MAPK/ERK pathway and Protein kinase B.
The various areas that Richard A. Franklin examines in his Cell biology study include Cell cycle, Jurkat cells and Cell growth.
Richard A. Franklin works mostly in the field of Cancer research, limiting it down to topics relating to Cancer and, in certain cases, Oncology, as a part of the same area of interest.
His Signal transduction study integrates concerns from other disciplines, such as Apoptosis, Cell culture and Cytokine.
His MAPK/ERK pathway research incorporates themes from Receptor, Stimulation and Mitogen-activated protein kinase kinase.
Richard A. Franklin interconnects Carcinogenesis, PI3K/AKT/mTOR pathway and Epidermal growth factor receptor in the investigation of issues within Protein kinase B.
He most often published in these fields:
- Cell biology (41.67%)
- Cancer research (37.04%)
- Signal transduction (36.11%)
What were the highlights of his more recent work (between 2006-2014)?
- Cancer research (37.04%)
- PI3K/AKT/mTOR pathway (24.07%)
- Protein kinase B (26.85%)
In recent papers he was focusing on the following fields of study:
Cancer research, PI3K/AKT/mTOR pathway, Protein kinase B, MAPK/ERK pathway and PTEN are his primary areas of study.
His biological study spans a wide range of topics, including Apoptosis and Cancer, Targeted therapy, Treatment resistance.
His PI3K/AKT/mTOR pathway study combines topics from a wide range of disciplines, such as Tamoxifen and Breast cancer.
His studies deal with areas such as Mediator and Tetrandrine as well as Protein kinase B.
Part of his project on MAPK/ERK pathway includes research on Cell biology and Signal transduction.
His PTEN research is multidisciplinary, incorporating elements of Carcinogenesis and Protein phosphatase 2.
Between 2006 and 2014, his most popular works were:
- ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE (1529 citations)
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health (423 citations)
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance (246 citations)
In his most recent research, the most cited papers focused on:
His primary areas of study are Protein kinase B, PI3K/AKT/mTOR pathway, PTEN, Cancer research and MAPK/ERK pathway.
His Protein kinase B study is related to the wider topic of Cell biology.
The study incorporates disciplines such as Tumor suppressor gene and Treatment resistance in addition to PI3K/AKT/mTOR pathway.
His Tumor suppressor gene study combines topics from a wide range of disciplines, such as Phosphatase and Tensin.
Cell growth is closely connected to Cell cycle in his research, which is encompassed under the umbrella topic of PTEN.
Kinase, Anti-apoptotic Ras signalling cascade and c-Raf are fields of study that intersect with his HRAS research.
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