World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
15188
World Ranking
17842
National Ranking
7302

Overview

Richard A. Franklin is affiliated with East Carolina University in the United States. Their research spans several areas within medicine and biochemistry, with a focus on oncology, molecular biology, and plant science. The scientist's work addresses various aspects of cancer biology, molecular pathways related to cancer, and the biological activity of phytochemical compounds.

Franklin has contributed to multiple research papers, including studies on anticancer effects, cancer cell metabolism, and the application of plant extracts in cancer treatment. Notable publications include:

  • Anti-cancer effects of green synthesized gold nanoparticles using leaf extract of Annona muricata. L against squamous cell carcinoma cell line 15 through apoptotic pathway, 2024, Dental Research Journal
  • Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties, 2022, Aging
  • Evaluation of the cytotoxic, anti-proliferative, anti-metastatic and pro-apoptotic effect of aqueous leaf extract of Annona muricata on oral tongue squamous cell carcinoma cell line (SCC-15): An in vitro study, 2023, Journal of Oral and Maxillofacial Pathology
  • Salivary duct carcinoma in the submandibular gland: A rare case report with differential diagnosis, 2024, Journal of Oral and Maxillofacial Pathology
  • Unveiling the Mysteries of Ameloblastoma: A Comprehensive Case Series on Odontogenic Lesions, 2025, Journal of Pharmacy And Bioallied Sciences

Frequent coauthors in Franklin's work include:

  • Prasanth Thankappan
  • S. Jeslin Mary
  • Veeran Veeravarmal
  • D Angelin
  • Paramasivam Arumugam

The scientist's work has appeared most often in the following venues:

  • Journal of Oral and Maxillofacial Pathology
  • Dental Research Journal
  • Aging
  • Journal of Pharmacy And Bioallied Sciences

Richard A. Franklin's main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within their research, subfields of interest are:

  • Oncology
  • Biochemistry
  • Molecular Biology
  • Plant Science
  • General Health Professions

Key research topics addressed by Franklin focus on:

  • Traditional and Medicinal Uses of Annonaceae
  • Moringa oleifera research and applications
  • Diverse Scientific Research Studies
  • Pancreatic and Hepatic Oncology Research
  • Cancer-related Molecular Pathways
  • Cancer, Hypoxia, and Metabolism
  • Phytochemical compounds biological activities

Best Publications

  • ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE

    James A. McCubrey;Linda S. Steelman;William H. Chappell;Stephen L. Abrams

  • Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy

    F Chang;J T Lee;P M Navolanic;L S Steelman

  • Reactive oxygen species-induced activation of the MAP kinase signaling pathways.

    James A. McCubrey;Michelle M. LaHair;Richard A. Franklin

  • Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention

    F Chang;L S Steelman;J T Lee;J G Shelton

  • JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.

    L S Steelman;S C Pohnert;J G Shelton;Richard A Franklin

  • Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

    James A. McCubrey;Linda S. Steelman;Steven L. Abrams;John T. Lee

  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

    William H. Chappell;Linda S. Steelman;Jacquelyn M. Long;Ruth C. Kempf

  • Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review)

    Fumin Chang;Linda S. Steelman;John G. Shelton;John T. Lee

  • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

    James Andrew McCubrey;Linda S. Steelman;William H. Chappell;Stephen L. Abrams

  • Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.

    L S Steelman;R A Franklin;S L Abrams;W Chappell

  • Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle

    Naohiro Terada;Joseph J. Lucas;Agota Szepesi;Richard A. Franklin

  • Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells : possible sites for intervention with anti-neoplastic drugs

    W. L. Blalock;C. Weinstein-Oppenheimer;C. Weinstein-Oppenheimer;F. Chang;P. E. Hoyle

  • Kinases: positive and negative regulators of apoptosis

    R A Franklin;J A McCubrey

  • Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

    Linda S. Steelman;Patrick M. Navolanic;Melissa L. Sokolosky;Jackson R. Taylor

  • Redox regulation of the calcium/calmodulin-dependent protein kinases.

    Christopher J. Howe;Michelle M. LaHair;James A. McCubrey;Richard A. Franklin

  • Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.

    Richard A. Franklin;Attila Tordai;Hiren Patel;Anne M. Gardner

  • Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

    JA McCubrey;LS Steelman;PE Hoyle;WL Blalock

  • Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells

    John G Shelton;Linda S Steelman;John T Lee;Steven L Knapp

  • Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin.

    Caroline R. Weinstein-Oppenheimer;Carlos F. Henríquez-Roldán;Julianne M. Davis;Patrick M. Navolanic

  • Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism.

    P E Hoyle;P W Moye;L S Steelman;W L Blalock

Frequent Co-Authors

James A. McCubrey
James A. McCubrey East Carolina University
Massimo Libra
Massimo Libra University of Catania
Alberto M. Martelli
Alberto M. Martelli University of Bologna
Erwin W. Gelfand
Erwin W. Gelfand University of Colorado Anschutz Medical Campus
Martin McMahon
Martin McMahon Huntsman Cancer Institute
Michele Milella
Michele Milella University of Verona
Naohiro Terada
Naohiro Terada University of Florida
Lucio Cocco
Lucio Cocco University of Bologna
Keith W. Kelley
Keith W. Kelley University of Illinois at Urbana-Champaign
Giuseppe Montalto
Giuseppe Montalto University of Palermo

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring a career in Biology or Biochemistry opens up a wide range of opportunities in healthcare, research, and the life sciences. For students looking for flexibility, online degree programs can offer affordable and accelerated pathways to professional roles. For example, if you’re interested in the intersection of biology and nutrition, consider pursuing an online nutrition degree. This is an excellent option for those who wish to promote healthy living or work in clinical environments.

Many biology majors continue their education in nursing. There are cheapest rn to bsn online programs that make it convenient for registered nurses to advance without breaking the bank. If your interests lead toward healthcare management, you may want to look into the fastest online mha programs to accelerate your leadership career.

Additionally, for those seeking advanced clinical practice, becoming a nurse practitioner is an attractive path. The fastest psych np program lets you focus on mental health—a growing field that values a strong background in biology and human sciences. With so many related options, online education makes it easier than ever to tailor your degree toward your ideal career pathway.

Best Scientists Citing Richard A. Franklin

Trending Scientists