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Molecular Biology

D-Index
85
Citations
28571
World Ranking
847
National Ranking
446

Overview

Martin McMahon is affiliated with the Huntsman Cancer Institute in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broader fields, they have a significant focus on Molecular Biology, Oncology, Cell Biology, Pulmonary and Respiratory Medicine, and Epidemiology.

The scientist's work concentrates on several main topics, including:

  • Melanoma and MAPK Pathways
  • PI3K/AKT/mTOR signaling in cancer
  • Autophagy in Disease and Therapy
  • Ubiquitin and proteasome pathways
  • Ocular Oncology and Treatments
  • Protein Degradation and Inhibitors
  • Advanced Breast Cancer Therapies

The publishing record of Martin McMahon includes multiple articles in prominent venues. Frequent publication venues consist of:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Oncogene
  • Pigment Cell & Melanoma Research

Some representative recent papers authored by or involving their contributions include:

  • "Melanoma models for the next generation of therapies," 2021, Cancer Cell
  • "Chloroquine Sensitizes GNAQ/11 -mutated Melanoma to MEK1/2 Inhibition," 2020, Clinical Cancer Research
  • "MYC-mediated resistance to trametinib and HCQ in PDAC is overcome by CDK4/6 and lysosomal inhibition," 2023, The Journal of Experimental Medicine
  • "Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer," 2020, Cell Reports
  • "Autophagy Inhibition in BRAF-Driven Cancers," 2021, Cancers

Frequent co-authors in their publications include:

  • Conan G. Kinsey
  • Michael T. Scherzer
  • Sheri L. Holmen
  • Amanda Truong
  • Gennie L. Parkman

Best Publications

  • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

    Sarah P. Thayer;Marina Pasca di Magliano;Patrick W. Heiser;Corinne M. Nielsen

  • Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

    Audrey Minden;Anning Lin;Martin McMahon;Carol Lange-Carter

  • BrafV600E cooperates with Pten loss to induce metastatic melanoma

    David Dankort;David P. Curley;Robert A. Cartlidge;Betsy Nelson

  • Senescence of human fibroblasts induced by oncogenic Raf

    Jiyue Zhu;Douglas Woods;Martin McMahon;J. Michael Bishop

  • Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

    Richard L. Friedman;Susan P. Manly;Martin McMahon;Ian M. Kerr

  • Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

    Meghna Das Thakur;Fernando Salangsang;Allison S. Landman;William R. Sellers

  • Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond

    Matthew Holderfield;Marian M. Deuker;Frank McCormick;Martin McMahon

  • Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

    Douglas Woods;David Parry;Holly Cherwinski;Elizabeth Bosch

  • A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

    David Dankort;Elena Filenova;Manuel Collado;Manuel Serrano

  • Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.

    Conan G. Kinsey;Conan G. Kinsey;Soledad A. Camolotto;Amelie M. Boespflug;Amelie M. Boespflug;Katrin P. Guillen

  • The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

    Luping Lin;Amit J Sabnis;Elton Chan;Victor Olivas

  • An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

    Devarati Mitra;Xi Luo;Ann Morgan;Jin Wang

  • Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

    Mayumi Onishi;Tetsuya Nosaka;Kazuhide Misawa;Alice L.-F. Mui

  • Opposing Effects of Ras on p53: Transcriptional Activation of mdm2 and Induction of p19ARF

    Stefan Ries;Carola Biederer;Douglas Woods;Ohad Shifman

  • Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BRAFV600E-Driven Lung Tumors

    Anne Marie Strohecker;Jessie Yanxiang Guo;Gizem Karsli-Uzunbas;Sandy M. Price

  • Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

    M L Samuels;M J Weber;J M Bishop;M McMahon

  • β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

    William E. Damsky;William E. Damsky;David P. Curley;David P. Curley;Manjula Santhanakrishnan;Lara E. Rosenbaum

  • Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells.

    Kerstin Lehmann;Elzbieta Janda;Christophe E. Pierreux;Marjatta Rytömaa

  • A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma

    Eric A. Collisson;Christy L. Trejo;Jillian M. Silva;Shenda Gu

  • Analysis of the transcriptional program induced by Raf in epithelial cells

    Almut Schulze;Kerstin Lehmann;Harold B. Jefferies;Martin McMahon

Frequent Co-Authors

Marcus Bosenberg
Marcus Bosenberg Yale University
James A. McCubrey
James A. McCubrey East Carolina University
Richard A. Franklin
Richard A. Franklin East Carolina University
Wayne A. Phillips
Wayne A. Phillips Peter MacCallum Cancer Centre
Keith T. Flaherty
Keith T. Flaherty Harvard University
Frank McCormick
Frank McCormick University of California, San Francisco
Alana L. Welm
Alana L. Welm University of Utah
David E. Fisher
David E. Fisher Harvard University
Simon J. Cook
Simon J. Cook Babraham Institute
Jennifer A. Wargo
Jennifer A. Wargo The University of Texas MD Anderson Cancer Center

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