Simon J. Cook

Overview

Best Publications

• Inhibition by cAMP of Ras-dependent activation of Raf

  Simon J. Cook;Frank McCormick

  1196
  Citations

• Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival.

  H. Llewelyn Roderick;H. Llewelyn Roderick;Simon J. Cook

  822
  Citations

• Characterization of Two Alternately Spliced Forms of Phospholipase D1 ACTIVATION OF THE PURIFIED ENZYMES BY PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE, ADP-RIBOSYLATION FACTOR, AND RHO FAMILY MONOMERIC GTP-BINDING PROTEINS AND PROTEIN KINASE C-α

  Scott M. Hammond;John M. Jenco;Shigeru Nakashima;Karen Cadwallader

  778
  Citations

• Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

  Rebecca Ley;Kathryn Balmanno;Kathryn Hadfield;Claire R. Weston

  776
  Citations

• MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.

  Christopher J. Caunt;Matthew J. Sale;Paul D. Smith;Simon J. Cook

  591
  Citations

• Tumour cell survival signalling by the ERK1/2 pathway.

  K Balmanno;S J Cook

  575
  Citations

• RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

  S J Cook;B Rubinfeld;I Albert;F McCormick

  498
  Citations

• FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency

  Gabriella Ficz;Timothy A. Hore;Fátima Santos;Heather J. Lee

  442
  Citations

• The role of MAPK signalling pathways in the response to endoplasmic reticulum stress

  Nicola J. Darling;Simon J. Cook

  405
  Citations

• Regulatory phosphorylation of Bim: sorting out the ERK from the JNK.

  R Ley;K E Ewings;K Hadfield;S J Cook

  389
  Citations

• Paclitaxel-Induced Nuclear Translocation of FOXO3a in Breast Cancer Cells Is Mediated by c-Jun NH2-Terminal Kinase and Akt

  Andrew Sunters;Patricia A. Madureira;Karen M. Pomeranz;Muriel Aubert

  319
  Citations

• Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells.

  Kathryn Balmanno;Simon J Cook

  305
  Citations

• The Selective Protein Kinase C Inhibitor, Ro-31-8220, Inhibits Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression, Induces c-Jun Expression, and Activates Jun N-terminal Kinase

  Jerlyn Beltman;Frank McCormick;Simon J. Cook

  269
  Citations

• The Repertoire of Fos and Jun Proteins Expressed during the G1 Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation

  Simon J. Cook;Simon J. Cook;Natasha Aziz;Martin McMahon

  252
  Citations

• Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover.

  Rebecca Ley;Katherine E. Ewings;Kathryn Hadfield;Elizabeth Howes

  249
  Citations

• Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism.

  S J Cook;M J O Wakelam

  248
  Citations

• Amplification of the Driving Oncogene, KRAS or BRAF, Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells

  Annette S. Little;Kathryn Balmanno;Matthew J. Sale;Scott Newman

  241
  Citations

• De-regulated FGF receptors as therapeutic targets in cancer.

  Victoria Knights;Simon J. Cook

  240
  Citations

• FGF signalling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency

  Gabriella Ficz;Timothy A Hore;Fatima Santos;Heather J Lee

  239
  Citations

• Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection.

  Parjeet K. Boughan;Richard H. Argent;Mathilde Body-Malapel;Jong-Hwan Park

  230
  Citations