D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 103 Citations 36,884 266 World Ranking 909 National Ranking 571

Research.com Recognitions

Awards & Achievements

2001 - Member of the National Academy of Sciences

1999 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Biochemistry
  • Amino acid

His primary areas of investigation include Biochemistry, Internal medicine, Endocrinology, Glucagon and Gluconeogenesis. His work on Biochemistry deals in particular with Phospholipase D, GTP', Phospholipase C, Protein kinase C and G protein. His research integrates issues of Molecular biology and G alpha subunit in his study of Phospholipase C.

His Endocrinology study combines topics from a wide range of disciplines, such as Urea and Amino acid, Alanine. The Glucagon study combines topics in areas such as Phosphodiesterase, Glycogenesis and Glycogenolysis. His work deals with themes such as Fructose, Adenosine, Glycogen, Ketogenesis and Starvation response, which intersect with Gluconeogenesis.

His most cited work include:

  • Signaling through phosphatidylcholine breakdown. (1142 citations)
  • Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. (869 citations)
  • Phosphatidylcholine breakdown and signal transduction (837 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Biochemistry, Endocrinology, Internal medicine, Phospholipase D and Molecular biology. All of his Biochemistry and Protein kinase C, G protein, GTP', Phospholipase and Phospholipase C investigations are sub-components of the entire Biochemistry study. His Protein kinase C research focuses on subjects like Protein kinase A, which are linked to Adenylate kinase.

His study in Glucagon, Glycogen phosphorylase, Gluconeogenesis, Epinephrine and Vasopressin falls under the purview of Endocrinology. His study in Phospholipase D is interdisciplinary in nature, drawing from both PLD2, Phospholipase D activity and ADP ribosylation factor. His work carried out in the field of Molecular biology brings together such families of science as Platelet-derived growth factor receptor, Kinase, Tyrosine phosphorylation, Phorbol and Autophosphorylation.

He most often published in these fields:

  • Biochemistry (47.54%)
  • Endocrinology (41.55%)
  • Internal medicine (41.55%)

What were the highlights of his more recent work (between 1999-2013)?

  • Phospholipase D (23.24%)
  • Biochemistry (47.54%)
  • Protein kinase C (17.96%)

In recent papers he was focusing on the following fields of study:

His main research concerns Phospholipase D, Biochemistry, Protein kinase C, Molecular biology and Cell biology. His Phospholipase D research includes elements of Phospholipase, PLD2, Phosphatidic acid, Phosphorylation and Membrane ruffling. His study ties his expertise on Wild type together with the subject of Biochemistry.

He combines subjects such as Enzyme activator, Phospholipase D1, Phospholipase D activity and Protein kinase A with his study of Protein kinase C. His Molecular biology study combines topics in areas such as Immunoprecipitation, Ionomycin, Tyrosine phosphorylation, Phorbol and Binding site. His work in Cell biology addresses subjects such as Actin cytoskeleton, which are connected to disciplines such as Actinin.

Between 1999 and 2013, his most popular works were:

  • Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression (554 citations)
  • Critical Role of Endogenous Akt/IAPs and MEK1/ERK Pathways in Counteracting Endoplasmic Reticulum Stress-induced Cell Death (283 citations)
  • Regulation of phospholipase D. (249 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Amino acid
  • Biochemistry

Phospholipase D, Biochemistry, Molecular biology, Protein kinase C and Cell biology are his primary areas of study. His Phospholipase D research is multidisciplinary, incorporating elements of Phosphatidic acid, PLD2, Phospholipase D activity, Chromatography and Lipase. His Molecular biology research incorporates elements of Diacylglycerol kinase, Ca2+/calmodulin-dependent protein kinase, Wortmannin, Guanine nucleotide exchange factor and Kinase.

His Protein kinase C research includes themes of Enzyme activator, Phospholipase D1, Ionomycin and Protein kinase A. His Protein kinase A research is multidisciplinary, relying on both Phorbol and C-terminus. His study on Cell biology is mostly dedicated to connecting different topics, such as Vinculin.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Signaling through phosphatidylcholine breakdown.

J H Exton.
Journal of Biological Chemistry (1990)

1814 Citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

H. Nakanishi;K.A. Brewer;J.H. Exton.
Journal of Biological Chemistry (1993)

1373 Citations

Phosphatidylcholine breakdown and signal transduction

J.H. Exton.
Biochimica et Biophysica Acta (1994)

1332 Citations

Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins.

Stephen J. Taylor;Stephen J. Taylor;Ho Zoon Chae;Sue Goo Rhee;John H. Exton.
Nature (1991)

1053 Citations

Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression

Ping Hu;Zhang Han;Anthony D. Couvillon;Randal J. Kaufman.
Molecular and Cellular Biology (2006)

853 Citations

Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats.

J.H. Exton;C.R. Park.
Journal of Biological Chemistry (1967)

611 Citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

S B Bocckino;P F Blackmore;P B Wilson;J H Exton.
Journal of Biological Chemistry (1987)

575 Citations

A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes

Timothy M. Chan;John H. Exton.
Analytical Biochemistry (1976)

571 Citations

Phospholipase D: enzymology, mechanisms of regulation, and function

J. H. Exton.
Physiological Reviews (1997)

562 Citations

Control of Gluconeogenesis from Amino Acids in the Perfused Rat Liver

L.E. Mallette;J.H. Exton;C.R. Park.
Journal of Biological Chemistry (1969)

562 Citations

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