2001 - Member of the National Academy of Sciences
1999 - Fellow of the American Association for the Advancement of Science (AAAS)
His primary areas of investigation include Biochemistry, Internal medicine, Endocrinology, Glucagon and Gluconeogenesis. His work on Biochemistry deals in particular with Phospholipase D, GTP', Phospholipase C, Protein kinase C and G protein. His research integrates issues of Molecular biology and G alpha subunit in his study of Phospholipase C.
His Endocrinology study combines topics from a wide range of disciplines, such as Urea and Amino acid, Alanine. The Glucagon study combines topics in areas such as Phosphodiesterase, Glycogenesis and Glycogenolysis. His work deals with themes such as Fructose, Adenosine, Glycogen, Ketogenesis and Starvation response, which intersect with Gluconeogenesis.
His scientific interests lie mostly in Biochemistry, Endocrinology, Internal medicine, Phospholipase D and Molecular biology. All of his Biochemistry and Protein kinase C, G protein, GTP', Phospholipase and Phospholipase C investigations are sub-components of the entire Biochemistry study. His Protein kinase C research focuses on subjects like Protein kinase A, which are linked to Adenylate kinase.
His study in Glucagon, Glycogen phosphorylase, Gluconeogenesis, Epinephrine and Vasopressin falls under the purview of Endocrinology. His study in Phospholipase D is interdisciplinary in nature, drawing from both PLD2, Phospholipase D activity and ADP ribosylation factor. His work carried out in the field of Molecular biology brings together such families of science as Platelet-derived growth factor receptor, Kinase, Tyrosine phosphorylation, Phorbol and Autophosphorylation.
His main research concerns Phospholipase D, Biochemistry, Protein kinase C, Molecular biology and Cell biology. His Phospholipase D research includes elements of Phospholipase, PLD2, Phosphatidic acid, Phosphorylation and Membrane ruffling. His study ties his expertise on Wild type together with the subject of Biochemistry.
He combines subjects such as Enzyme activator, Phospholipase D1, Phospholipase D activity and Protein kinase A with his study of Protein kinase C. His Molecular biology study combines topics in areas such as Immunoprecipitation, Ionomycin, Tyrosine phosphorylation, Phorbol and Binding site. His work in Cell biology addresses subjects such as Actin cytoskeleton, which are connected to disciplines such as Actinin.
Phospholipase D, Biochemistry, Molecular biology, Protein kinase C and Cell biology are his primary areas of study. His Phospholipase D research is multidisciplinary, incorporating elements of Phosphatidic acid, PLD2, Phospholipase D activity, Chromatography and Lipase. His Molecular biology research incorporates elements of Diacylglycerol kinase, Ca2+/calmodulin-dependent protein kinase, Wortmannin, Guanine nucleotide exchange factor and Kinase.
His Protein kinase C research includes themes of Enzyme activator, Phospholipase D1, Ionomycin and Protein kinase A. His Protein kinase A research is multidisciplinary, relying on both Phorbol and C-terminus. His study on Cell biology is mostly dedicated to connecting different topics, such as Vinculin.
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Signaling through phosphatidylcholine breakdown.
J H Exton.
Journal of Biological Chemistry (1990)
Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.
H. Nakanishi;K.A. Brewer;J.H. Exton.
Journal of Biological Chemistry (1993)
Phosphatidylcholine breakdown and signal transduction
Biochimica et Biophysica Acta (1994)
Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins.
Stephen J. Taylor;Stephen J. Taylor;Ho Zoon Chae;Sue Goo Rhee;John H. Exton.
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression
Ping Hu;Zhang Han;Anthony D. Couvillon;Randal J. Kaufman.
Molecular and Cellular Biology (2006)
Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats.
J.H. Exton;C.R. Park.
Journal of Biological Chemistry (1967)
Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.
S B Bocckino;P F Blackmore;P B Wilson;J H Exton.
Journal of Biological Chemistry (1987)
A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes
Timothy M. Chan;John H. Exton.
Analytical Biochemistry (1976)
Phospholipase D: enzymology, mechanisms of regulation, and function
J. H. Exton.
Physiological Reviews (1997)
Control of Gluconeogenesis from Amino Acids in the Perfused Rat Liver
L.E. Mallette;J.H. Exton;C.R. Park.
Journal of Biological Chemistry (1969)
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