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D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
15833
World Ranking
8655
National Ranking
3884

Overview

Alan V. Smrcka is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with additional work in Medicine. Within these domains, their focus narrows to molecular biology, cellular and molecular neuroscience, genetics, oncology, and cell biology as prominent subfields.

Their scholarly contributions address several main topics including receptor mechanisms and signaling, protein kinase regulation and GTPase signaling, neuropeptides and animal physiology, blood disorders and treatments, cellular transport and secretion, chemokine receptors and signaling, and pain mechanisms and treatments.

Alan V. Smrcka has published extensively in certain venues, showing repeated collaboration with specific journals:

  • The FASEB Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Journal of Biological Chemistry

Several frequent coauthors have worked with Smrcka, indicating ongoing research partnerships. These coauthors include:

  • Naincy R. Chandan
  • Tyler J. Lefevre
  • Nagarajan Vaidehi
  • Saji Abraham
  • Emily M. Jutkiewicz

Notable recent publications by Alan V. Smrcka feature a range of topics relevant to their research fields:

  • "AI is a viable alternative to high throughput screening: a 318-target study," 2024, Scientific Reports
  • "A universal allosteric mechanism for G protein activation," 2021, Molecular Cell
  • "Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition," 2020, Structure
  • "Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils," 2020, Molecular Pharmacology
  • "A network of Gα i signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF," 2022, Science Signaling

Best Publications

  • Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq

    Alan V. Smrcka;John R. Hepler;Kendall O. Brown;Paul C. Sternweis

  • Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

    Zhong Li;Huiping Jiang;Wei Xie;Zuchuan Zhang

  • A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

    L. Stephens;A. Smrcka;F. T. Cooke;T. R. Jackson

  • Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.

    Bernward Hinkes;Roger C. Wiggins;Rasheed Gbadegesin;Christopher N. Vlangos

  • Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits.

    Alan V. Smrcka;Paul C. Sternweis

  • Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42

    Zhong Li;Michael Hannigan;Zhicheng Mo;Bo Liu

  • G protein βγ subunits: central mediators of G protein-coupled receptor signaling.

    A. V. Smrcka

  • Phospholipase Cϵ: a novel Ras effector

    Grant G. Kelley;Sarah E. Reks;Joanne M. Ondrako;Alan V. Smrcka

  • Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

    Stephen Gutowski;Alan Smrcka;Lisa Nowak;Dianging Wu

  • Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1.

    Gabriel Berstein;Jonathan L. Blank;Alan V. Smrcka;Tsutomu Higashijima

  • Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits.

    John R. Hepler;Tohru Kozasa;Alan V. Smrcka;Melvin I. Simon

  • Regulation of phospholipase C by G proteins.

    Paul C. Sternweis;Alan V. Smrcka

  • Differential Targeting of Gßγ-Subunit Signaling with Small Molecules

    Tabetha M. Bonacci;Jennifer L. Mathews;Chujun Yuan;David M. Lehmann

  • Small Molecule Disruption of G Protein βγ Subunit Signaling Inhibits Neutrophil Chemotaxis and Inflammation

    D. M. Lehmann;A. M. P. B. Seneviratne;A. V. Smrcka

  • Epac and Phospholipase Cϵ Regulate Ca2+ Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II

    Emily A. Oestreich;Sundeep Malik;Sanjeewa A. Goonasekera;Burns C. Blaxall

  • G protein beta gamma subunits. Simplified purification and properties of novel isoforms.

    Natsuo Ueda;Jorge A. Iñiguez-Lluhi;Ethan Lee;Alan V. Smrcka

  • Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes.

    Emily A. Oestreich;Huan Wang;Sundeep Malik;Katherine A. Kaproth-Joslin

  • Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids

    Wei Xie;Gary M. Samoriski;Jay P. McLaughlin;Valerie A. Romoser

  • Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors

    Huiping Jiang;Yanan Kuang;Yanping Wu;Alan Smrcka

  • Role of phospholipase Cε in physiological phosphoinositide signaling networks.

    Alan V. Smrcka;Joan Heller Brown;George G. Holz

Frequent Co-Authors

Paul C. Sternweis
Paul C. Sternweis The University of Texas Southwestern Medical Center
Joan Heller Brown
Joan Heller Brown University of California, San Diego
Youming Lu
Youming Lu Huazhong University of Science and Technology
Stephen M. Lanier
Stephen M. Lanier Wayne State University
Friedhelm Hildebrandt
Friedhelm Hildebrandt Boston Children's Hospital
Thomas Gudermann
Thomas Gudermann Ludwig-Maximilians-Universität München
John R. Hepler
John R. Hepler Emory University
George G. Holz
George G. Holz SUNY Upstate Medical University
Robert T. Dirksen
Robert T. Dirksen University of Rochester
Alexander Dietrich
Alexander Dietrich Ludwig-Maximilians-Universität München

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