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D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
15833
World Ranking
8655
National Ranking
3884

Alan V. Smrcka publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Alan V. Smrcka sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 223 publications — 58th percentile

58% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Alan V. Smrcka D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Alan V. Smrcka sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 66 D-Index — 57th percentile

57% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Alan V. Smrcka is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with additional work in Medicine. Within these domains, their focus narrows to molecular biology, cellular and molecular neuroscience, genetics, oncology, and cell biology as prominent subfields.

Their scholarly contributions address several main topics including receptor mechanisms and signaling, protein kinase regulation and GTPase signaling, neuropeptides and animal physiology, blood disorders and treatments, cellular transport and secretion, chemokine receptors and signaling, and pain mechanisms and treatments.

Alan V. Smrcka has published extensively in certain venues, showing repeated collaboration with specific journals:

  • The FASEB Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Journal of Biological Chemistry

Several frequent coauthors have worked with Smrcka, indicating ongoing research partnerships. These coauthors include:

  • Naincy R. Chandan
  • Tyler J. Lefevre
  • Nagarajan Vaidehi
  • Saji Abraham
  • Emily M. Jutkiewicz

Notable recent publications by Alan V. Smrcka feature a range of topics relevant to their research fields:

  • "AI is a viable alternative to high throughput screening: a 318-target study," 2024, Scientific Reports
  • "A universal allosteric mechanism for G protein activation," 2021, Molecular Cell
  • "Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition," 2020, Structure
  • "Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils," 2020, Molecular Pharmacology
  • "A network of Gα i signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF," 2022, Science Signaling

Best Publications

  • Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq

    Alan V. Smrcka;John R. Hepler;Kendall O. Brown;Paul C. Sternweis

  • Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

    Zhong Li;Huiping Jiang;Wei Xie;Zuchuan Zhang

  • A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

    L. Stephens;A. Smrcka;F. T. Cooke;T. R. Jackson

  • Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.

    Bernward Hinkes;Roger C. Wiggins;Rasheed Gbadegesin;Christopher N. Vlangos

  • Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits.

    Alan V. Smrcka;Paul C. Sternweis

  • Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42

    Zhong Li;Michael Hannigan;Zhicheng Mo;Bo Liu

  • G protein βγ subunits: central mediators of G protein-coupled receptor signaling.

    A. V. Smrcka

  • Phospholipase Cϵ: a novel Ras effector

    Grant G. Kelley;Sarah E. Reks;Joanne M. Ondrako;Alan V. Smrcka

  • Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

    Stephen Gutowski;Alan Smrcka;Lisa Nowak;Dianging Wu

  • Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1.

    Gabriel Berstein;Jonathan L. Blank;Alan V. Smrcka;Tsutomu Higashijima

  • Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits.

    John R. Hepler;Tohru Kozasa;Alan V. Smrcka;Melvin I. Simon

  • Regulation of phospholipase C by G proteins.

    Paul C. Sternweis;Alan V. Smrcka

  • Differential Targeting of Gßγ-Subunit Signaling with Small Molecules

    Tabetha M. Bonacci;Jennifer L. Mathews;Chujun Yuan;David M. Lehmann

  • Small Molecule Disruption of G Protein βγ Subunit Signaling Inhibits Neutrophil Chemotaxis and Inflammation

    D. M. Lehmann;A. M. P. B. Seneviratne;A. V. Smrcka

  • Epac and Phospholipase Cϵ Regulate Ca2+ Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II

    Emily A. Oestreich;Sundeep Malik;Sanjeewa A. Goonasekera;Burns C. Blaxall

  • G protein beta gamma subunits. Simplified purification and properties of novel isoforms.

    Natsuo Ueda;Jorge A. Iñiguez-Lluhi;Ethan Lee;Alan V. Smrcka

  • Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes.

    Emily A. Oestreich;Huan Wang;Sundeep Malik;Katherine A. Kaproth-Joslin

  • Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids

    Wei Xie;Gary M. Samoriski;Jay P. McLaughlin;Valerie A. Romoser

  • Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors

    Huiping Jiang;Yanan Kuang;Yanping Wu;Alan Smrcka

  • Role of phospholipase Cε in physiological phosphoinositide signaling networks.

    Alan V. Smrcka;Joan Heller Brown;George G. Holz

Frequent Co-Authors

Paul C. Sternweis
Paul C. Sternweis The University of Texas Southwestern Medical Center
Joan Heller Brown
Joan Heller Brown University of California, San Diego
Youming Lu
Youming Lu Huazhong University of Science and Technology
Stephen M. Lanier
Stephen M. Lanier Wayne State University
Friedhelm Hildebrandt
Friedhelm Hildebrandt Boston Children's Hospital
Thomas Gudermann
Thomas Gudermann Ludwig-Maximilians-Universität München
John R. Hepler
John R. Hepler Emory University
George G. Holz
George G. Holz SUNY Upstate Medical University
Robert T. Dirksen
Robert T. Dirksen University of Rochester
Alexander Dietrich
Alexander Dietrich Ludwig-Maximilians-Universität München

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