The scientist’s investigation covers issues in G protein, Biochemistry, Signal transduction, Phospholipase C and Cell biology. His G protein research is multidisciplinary, incorporating elements of Molecular biology, Adenylyl cyclase and Protein–protein interaction. His Biochemistry research includes themes of Alpha, Beta and G alpha subunit.
His biological study spans a wide range of topics, including NADPH oxidase, Chemotaxis and Effector. His Phospholipase C research is multidisciplinary, incorporating perspectives in Protein kinase C, Protein kinase A and Gq alpha subunit. His work deals with themes such as Receptor and Lipid signaling, which intersect with Cell biology.
His primary areas of investigation include Cell biology, G protein, Biochemistry, Phospholipase C and Signal transduction. Alan V. Smrcka works mostly in the field of Cell biology, limiting it down to topics relating to Receptor and, in certain cases, Pharmacology and Effector. The various areas that Alan V. Smrcka examines in his G protein study include Molecular biology and Binding site.
His Biochemistry research integrates issues from Alpha, Beta and G alpha subunit. His Phospholipase C research incorporates elements of Phospholipase, Endocrinology, Diacylglycerol kinase and Gq alpha subunit. His research in Signal transduction intersects with topics in Chemotaxis and Phosphorylation.
Alan V. Smrcka mainly investigates Cell biology, G protein-coupled receptor, Golgi apparatus, G protein and Receptor. His Cell biology research incorporates themes from Hydrolysis and Adrenergic receptor. The G protein-coupled receptor study combines topics in areas such as Endocytic cycle, Cell, Integrin and Motility.
His G protein study necessitates a more in-depth grasp of Signal transduction. His research integrates issues of Cell signaling and Intracellular in his study of Receptor. His Phospholipase C study combines topics in areas such as Phosphatidylinositol 4-phosphate, Endocrinology, Diacylglycerol kinase and Protein kinase A.
His scientific interests lie mostly in Cell biology, G protein-coupled receptor, Golgi apparatus, G protein and Receptor. His research in Phospholipase C and Phosphatidylinositol are components of Cell biology. His study in G protein-coupled receptor is interdisciplinary in nature, drawing from both Stimulation, Computational biology, Signalling and Effector.
His biological study deals with issues like Second messenger system, which deal with fields such as G protein-coupled receptor kinase and G Protein-Coupled Receptor Signaling. His G protein study is related to the wider topic of Signal transduction. His Receptor study incorporates themes from Cell and Motility.
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Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq
Alan V. Smrcka;John R. Hepler;Kendall O. Brown;Paul C. Sternweis.
Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction
Zhong Li;Huiping Jiang;Wei Xie;Zuchuan Zhang.
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
L. Stephens;A. Smrcka;F. T. Cooke;T. R. Jackson.
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
Bernward Hinkes;Roger C. Wiggins;Rasheed Gbadegesin;Christopher N. Vlangos.
Nature Genetics (2006)
Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits.
Alan V. Smrcka;Paul C. Sternweis.
Journal of Biological Chemistry (1993)
Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42
Zhong Li;Michael Hannigan;Zhicheng Mo;Bo Liu.
Phospholipase Cϵ: a novel Ras effector
Grant G. Kelley;Sarah E. Reks;Joanne M. Ondrako;Alan V. Smrcka.
The EMBO Journal (2001)
Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.
Stephen Gutowski;Alan Smrcka;Lisa Nowak;Dianging Wu.
Journal of Biological Chemistry (1991)
G protein βγ subunits: central mediators of G protein-coupled receptor signaling.
A. V. Smrcka.
Cellular and Molecular Life Sciences (2008)
Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1.
Gabriel Berstein;Jonathan L. Blank;Alan V. Smrcka;Tsutomu Higashijima.
Journal of Biological Chemistry (1992)
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