Matthias P. Wymann

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award

Overview

Best Publications

• Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation

  Emilio Hirsch;Vladimir L. Katanaev;Cecilia Garlanda;Ornella Azzolino

  1544
  Citations

• Lipid signalling in disease

  Matthias P. Wymann;Roger Schneiter

  1512
  Citations

• Structural Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

  Edward H. Walker;Michael E. Pacold;Olga Perisic;Len Stephens

  1471
  Citations

• Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

  A Arcaro;M P Wymann

  1466
  Citations

• Structure and function of phosphoinositide 3-kinases

  Matthias P Wymann;Luciano Pirola

  919
  Citations

• Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

  Montserrat Camps;Thomas Rückle;Hong Ji;Vittoria Ardissone

  896
  Citations

• Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.

  M P Wymann;G Bulgarelli-Leva;M J Zvelebil;L Pirola

  889
  Citations

• Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

  Michael A. Crackower;Gavin Y. Oudit;Ivona Kozieradzki;Ivona Kozieradzki;Renu Sarao;Renu Sarao

  782
  Citations

• Targeting phosphoinositide 3-kinase—Moving towards therapy

  Romina Marone;Vladimir Cmiljanovic;Bernd Giese;Matthias P. Wymann

  745
  Citations

• Phosphoinositide 3-kinase signalling – which way to target?

  Matthias P Wymann;Marketa Zvelebil;Muriel Laffargue

  590
  Citations

• PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

  Enrico Patrucco;Antonella Notte;Laura Barberis;Giulio Selvetella

  584
  Citations

• Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons

  Heng-Ye Man;Qinhua Wang;Wei-Yang Lu;William Ju

  448
  Citations

• Bifurcation of Lipid and Protein Kinase Signals of PI3Kγ to the Protein Kinases PKB and MAPK

  Tzvetanka Bondeva;Luciano Pirola;Ginette Bulgarelli-Leva;Ignacio Rubio

  435
  Citations

• Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function

  Muriel Laffargue;Ronan Calvez;Peter Finan;Alexandre Trifilieff

  390
  Citations

• Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

  Alison M. Condliffe;Keith Davidson;Karen E. Anderson;Chris D. Ellson

  371
  Citations

• Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, Rho-, and Rac-dependent signaling pathways

  Samir Attoub;Veerle Noe;Luciano Pirola;Erik Bruyneel

  331
  Citations

• Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

  Elisa Ciraolo;Manuela Iezzi;Romina Marone;Stefano Marengo

  306
  Citations

• Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.

  Marcus Thelen;Matthias P. Wymann;Hanno Langen

  303
  Citations

• Turning on the respiratory burst.

  Marco Baggiolini;Matthias P. Wymann

  302
  Citations

• PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis

  G John Ferguson;Laura Milne;Suhasini Kulkarni;Takehiko Sasaki

  299
  Citations