World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
16924
World Ranking
10640
National Ranking
29

Research.com Recognitions

  • 2016 - Fellow of the Royal Society of New Zealand

Overview

Peter R. Shepherd is affiliated with the University of Auckland in New Zealand. Their research spans multiple fields, including Biochemistry, Genetics and Molecular Biology, and Medicine, with particular focus on Molecular Biology, Surgery, Endocrinology, Diabetes and Metabolism, Physiology, and Genetics.

The scientist's work covers numerous topics related to metabolism, diabetes, cancer, and cellular signaling processes. Key research areas include:

  • Metabolism, Diabetes, and Cancer
  • Pancreatic function and diabetes
  • Adipose Tissue and Metabolism
  • Wnt/β-catenin signaling in development and cancer
  • Cancer-related gene regulation
  • Melanoma and MAPK Pathways
  • Muscle Physiology and Disorders

Frequent publication venues for Shepherd's work include bioRxiv (Cold Spring Harbor Laboratory), Bioscience Reports, Biochemical Journal, Diabetes Research and Clinical Practice, and Molecular Metabolism. These diverse platforms reflect interdisciplinary research interests and contributions to both preprint and peer-reviewed scientific literature.

Co-authorship collaborations are notable with several researchers, indicating multidisciplinary and team-based investigation approaches. Regular co-authors include Troy L. Merry, Rinki Murphy, Kate Lee, Waruni C. Dissanayake, and Brie Sorrenson, with varying counts of joint publications showcasing ongoing scientific partnerships.

Among recent significant papers authored or co-authored by Shepherd are:

  • β-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding, 2020, Molecular Metabolism
  • Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK, 2021, BMC Cancer
  • Evolution of Molecular Targets in Melanoma Treatment, 2020, Current Pharmaceutical Design
  • β-Catenin is required for optimal exercise- and contraction-stimulated skeletal muscle glucose uptake, 2021, The Journal of Physiology
  • The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry, 2021, Diabetologia

Peter R. Shepherd has been recognized as a Fellow of the Royal Society of New Zealand since 2016, which signals participation in the scientific community at a national level.

Best Publications

  • Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus.

    Peter R. Shepherd;Barbara B. Kahn

  • Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

    Barbara T. Navé;D. Margriet Ouwens;Dominic J. Withers;Dario R. Alessi

  • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

    Laura S Harrington;Greg M Findlay;Alexander Gray;Tatiana Tolkacheva

  • PHOSPHOINOSITIDE 3-KINASE : THE KEY SWITCH MECHANISM IN INSULIN SIGNALLING

    Peter R. Shepherd;Dominic J. Withers;Kenneth Siddle

  • PI 3-kinase p110β: a new target for antithrombotic therapy

    Shaun P Jackson;Simone Marianne Schoenwaelder;Isaac Goncalves;Warwick Scott Nesbitt

  • Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.

    P. R. Shepherd;L. Gnudi;E. Tozzo;Huanming Yang

  • Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance

    V. A. Hughes;M. A. Fiatarone;R. A. Fielding;B. B. Kahn

  • Thr2446 Is a Novel Mammalian Target of Rapamycin (mTOR) Phosphorylation Site Regulated by Nutrient Status

    Susan W.Y. Cheng;Lee G.D. Fryer;David Carling;Peter R. Shepherd

  • Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase.

    P R Shepherd;B T Navé;K Siddle

  • Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

    Claire Chaussade;Gordon W. Rewcastle;Jackie D. Kendall;William A. Denny

  • Altered adipocyte properties in the offspring of protein malnourished rats.

    P.R Shepherd;N.J Crowther;M Desai;C.N Hales

  • The Role of Phosphoinositide 3-Kinase C2α in Insulin Signaling

    Marco Falasca;William E. Hughes;Veronica Dominguez;Gianluca Sala

  • Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues.

    P. R. Shepherd

  • Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes

    S. E. Ozanne;B. T. Nave;C. L. Wang;P. R. Shepherd

  • Insulin activates the alpha isoform of class II phosphoinositide 3-kinase.

    Richard A. Brown;Jan Domin;Alexandre Arcaro;Michael D. Waterfield;Michael D. Waterfield

  • A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

    Stephen Jamieson;Jack U. Flanagan;Sharada Kolekar;Christina Buchanan

  • Phosphoinositide 3-kinases and membrane traffic.

    Peter R. Shepherd;Barbara J. Reaves;Howard W. Davidson

  • G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

    Hashem A. Dbouk;Oscar Vadas;Aliaksei Shymanets;John E. Burke

  • Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.

    Lazaros C. Foukas;Nathalie Daniele;Chariklia Ktori;Karen E. Anderson

  • Leptin Rapidly Improves Glucose Homeostasis in Obese Mice by Increasing Hypothalamic Insulin Sensitivity

    Christiane Koch;Rachael A. Augustine;Juliane Steger;Goutham K. Ganjam

Frequent Co-Authors

William A. Denny
William A. Denny University of Auckland
Bruce C. Baguley
Bruce C. Baguley University of Auckland
David R. Grattan
David R. Grattan University of Otago
Tony R. Merriman
Tony R. Merriman University of Otago
Kenneth Siddle
Kenneth Siddle University of Cambridge
Weiping Han
Weiping Han Institute of Molecular and Cell Biology
Ming-Wei Wang
Ming-Wei Wang Chinese Academy of Sciences
Barbara B. Kahn
Barbara B. Kahn Beth Israel Deaconess Medical Center
Brian G. Oliver
Brian G. Oliver Woolcock Institute of Medical Research
Stephen O'Rahilly
Stephen O'Rahilly University of Cambridge

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