William A. Denny

Research.com Recognitions

• 2026 - Research.com Chemistry in New Zealand Leader Award
• 2025 - Research.com Chemistry in New Zealand Leader Award
• 2022 - Research.com Chemistry in New Zealand Leader Award

Overview

Best Publications

• Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

  Denise A. Chan;Patrick D. Sutphin;Phuong Nguyen;Sandra Turcotte

  613
  Citations

• Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

  David W. Fry;Alexander J. Bridges;William A. Denny;Annette Doherty

  573
  Citations

• Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor

  Alexander J. Bridges;Hairong Zhou;Donna R. Cody;Gordon W. Rewcastle

  524
  Citations

• Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

  Alexander James Bridges;William Alexander Denny;David Fry;Alan Kraker

  510
  Citations

• Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-intercalating agents which may not act via topoisomerase II.

  William A. Denny;Gordon W. Rewcastle;Bruce C. Baguley

  475
  Citations

• Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions.

  J. B. Smaill;G. W. Rewcastle;J. A. Loo;K. D. Greis

  443
  Citations

• Prodrug strategies in cancer therapy.

  William A Denny

  435
  Citations

• Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth factor receptor.

  Gordon W. Rewcastle;William A. Denny;Alexander J. Bridges;Hairong Zhou

  415
  Citations

• Interactions of antitumor drugs with natural DNA: 1H NMR study of binding mode and kinetics.

  Juli Feigon;William A. Denny;Werner Leupin;David R. Kearns

  389
  Citations

• Acridine derivatives as chemotherapeutic agents.

  William A. Denny

  388
  Citations

• DNA-intercalating ligands as anti-cancer drugs: prospects for future design.

  Denny Wa

  340
  Citations

• Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor.

  J. B. Smaill;B. D. Palmer;G. W. Rewcastle;W. A. Denny

  311
  Citations

• A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.

  Jharna Datta;Kalpana Ghoshal;William A. Denny;Swarna A. Gamage

  300
  Citations

• Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides.

  Shama Dissanayake;William A Denny;Swarna Gamage;Vijayalekshmi Sarojini

  299
  Citations

• POTENTIAL ANTITUMOR AGENTS. 34. QUANTITATIVE RELATIONSHIPS BETWEEN DNA BINDING AND MOLECULAR STRUCTURE FOR 9-ANILINOACRIDINES SUBSTITUTED IN THE ANILINO RING

  B. C. Baguley;W. A. Denny;G. J. Atwell;B. F. Cain

  291
  Citations

• Two-dimensional proton nuclear magnetic resonance investigation of the synthetic deoxyribonucleic acid decamer d(ATATCGATAT)2.

  Juli Feigon;Werner Leupin;William A. Denny;David R. Kearns

  291
  Citations

• A molecule targeting VHL-deficient Renal Cell Carcinoma that induces autophagy

  Sandra Turcotte;Denise A. Chan;Patrick D. Sutphin;Michael P. Hay

  288
  Citations

• Genotoxicity of non-covalent interactions: DNA intercalators.

  Lynnette R. Ferguson;William A. Denny

  287
  Citations

• Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.

  Graham J. Atwell;Gordon W. Rewcastle;Bruce C. Baguley;William A. Denny

  282
  Citations

• Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

  Claire Chaussade;Gordon W. Rewcastle;Jackie D. Kendall;William A. Denny

  270
  Citations

• Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards.

  David C. Ware;Brian D. Palmer;William R. Wilson;William A. Denny

  266
  Citations

• Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids.

  G W Rewcastle;G J Atwell;Z A Li;B C Baguley

  266
  Citations

• Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104

  Adam V. Patterson;Dianne M. Ferry;Shelley J. Edmunds;Yongchuan Gu

  264
  Citations