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Molecular Biology

D-Index
65
Citations
16997
World Ranking
1662
National Ranking
129

Overview

Michael J. Waring was affiliated with the University of Cambridge in the United Kingdom. Their research focused extensively on the fields of biochemistry, genetics, and molecular biology, alongside significant contributions in chemistry.

Their scholarly output spanned key subfields such as molecular biology, organic chemistry, materials chemistry, radiology, nuclear medicine and imaging, and computational theory and mathematics. These areas reflect a broad engagement with both experimental and theoretical aspects of the life sciences and chemistry.

The primary topics in Michael J. Waring's research included chemical synthesis and analysis, click chemistry and applications, RNA and protein synthesis mechanisms, monoclonal and polyclonal antibodies research, computational drug discovery methods, protein degradation and inhibitors, and crystallization and solubility studies.

Frequent publication venues for their work were:

  • Journal of Medicinal Chemistry
  • Bioorganic & Medicinal Chemistry
  • The Cambridge Structural Database
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Chemical Science

The scientist collaborated regularly with several co-authors, including Mathew P. Martin, M.E.M. Noble, Harriet A. Stanway-Gordon, Lan Z. Wang, and Jessica S. Graham.

Significant recent publications included:

  • Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease, 2020, Nature Communications
  • Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors, 2020, Journal of the American Chemical Society
  • Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries, 2021, Chemical Science
  • The Maturation of DNA Encoded Libraries: Opportunities for New Users, 2020, Future Medicinal Chemistry

Best Publications

  • Complex formation between ethidium bromide and nucleic acids.

    M.J. Waring

  • Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: evidence for molecular models involving intercalation.

    Michael Waring

  • DNA modification and cancer.

    M J Waring

  • DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata.

    Yves Pommier;Glenda Kohlhagen;Christian Bailly;Michael Waring

  • Molecular Aspects of Anticancer Drug-DNA Interactions

    Stephen Neidle;Michael J. Waring

  • Nucleotide Sequence Repetition: A Rapidly Reassociating Fraction of Mouse DNA

    Michael Waring;Roy J. Britten

  • Supercoiling of polyoma virus DNA measured by its interaction with ethidium bromide

    L.V. Crawford;M.J. Waring

  • Echinomycin: a bifunctional intercalating antibiotic.

    M. J. Waring;L. P. G. Wakelin

  • Drugs which affect the Structure and Function of DNA

    Waring Mj

  • Assignment of DNA binding sites for 4′,6-diamidine-2-phenylindole and bisbenzimide (Hoechst 33258). A comparative footprinting study

    Jose Portugal;Michael J. Waring

  • DNA structural variations produced by actinomycin and distamycin as revealed by DNAase I footprinting

    Keith R. Fox;Michael J. Waring

  • Preferential binding of daunomycin to 5'ATCG and 5'ATGC sequences revealed by footprinting titration experiments.

    Jonathan B. Chaires;Julio E. Herrera;Michael J. Waring

  • Site and sequence specificity of the daunomycin-DNA interaction.

    Jonathan B. Chaires;Keith R. Fox;Julio E. Herrera;Mark Britt

  • Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences

    C.M.Loretta Low;Horace R. Drew;Michael J. Waring

  • The binding of echinomycin to deoxyribonucleic acid

    S P Wakelin;M J Waring

  • Structural requirements for the binding of ethidium to nucleic acids.

    M.J. Waring

  • Synthesis of a Functionalized Salen−Copper Complex and Its Interaction with DNA

    Sylvain Routier;Jean-Luc Bernier;Michael J. Waring;Pierre Colson

  • A non-intercalating proflavine derivative.

    Werner Müller;Donald M. Crothers;Michael J. Waring

  • Comparison of binding sites in DNA for berenil, netropsin and distamycin. A footprinting study.

    José Portugal;Michael J. Waring

  • 2,3-Bifunctionalized Quinoxalines: Synthesis, DNA Interactions and Evaluation of Anticancer, Anti-tuberculosis and Antifungal Activity

    Michael J. Waring;Taibi Ben-Hadda;Ann T. Kotchevar;Abdelkrim Ramdani

Frequent Co-Authors

Keith R. Fox
Keith R. Fox University of Southampton
Christian Bailly
Christian Bailly Université Catholique de Louvain
Jonathan B. Chaires
Jonathan B. Chaires University of Louisville
Claude Hélène
Claude Hélène Grenoble Alpes University
Andrew Travers
Andrew Travers MRC Laboratory of Molecular Biology
Christophe Marchand
Christophe Marchand National Institutes of Health
Stephen Neidle
Stephen Neidle University College London
Maria Tomasz
Maria Tomasz City University of New York
William A. Denny
William A. Denny University of Auckland
George M. Sheldrick
George M. Sheldrick University of Göttingen

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