World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
53
Citations
9468
World Ranking
13130
National Ranking
740

Molecular Biology

D-Index
53
Citations
9440
World Ranking
2392
National Ranking
185

Overview

Keith R. Fox is affiliated with the University of Southampton in the United Kingdom. Their research spans multiple disciplines, primarily within biochemistry, genetics, and molecular biology, as well as medicine. The scientist's work involves detailed studies in molecular biology and oncology, with significant contributions to organic chemistry and infectious diseases. Radiology, nuclear medicine, and imaging are also represented among their subfields.

Their recent publications demonstrate a focus on cancer therapeutics, DNA and nucleic acid chemistry, and research into HER2/EGFR in cancer. Other main topics include mechanisms of RNA and protein synthesis, investigations related to monoclonal and polyclonal antibodies, the synthesis and pharmacology of benzodiazepine derivatives, and advances in click chemistry and its applications.

The following recent papers provide insight into the scope of their research:

  • Melting temperature measurement and mesoscopic evaluation of single, double and triple DNA mismatches, 2020, Chemical Science
  • The Novel DNA Binding Mechanism of Ridinilazole, a Precision Clostridiodes difficile Antibiotic, 2023, Antimicrobial Agents and Chemotherapy
  • Synthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates, 2020, Molecules
  • DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies, 2022, Communications Biology
  • DNA Structural Changes Induced by Intermolecular Triple Helix Formation, 2020, ACS Omega

Frequent coauthors in their research collaborations include:

  • Khondaker Miraz Rahman (6 collaborations)
  • David E. Thurston (6 collaborations)
  • George Procopiou (5 collaborations)
  • Paul J. Jackson (5 collaborations)
  • Paolo Andriollo (4 collaborations)

Key publication venues where Keith R. Fox has contributed multiple papers include:

  • Cancer Research (2 papers)
  • Chemical Science (1 paper)
  • Antimicrobial Agents and Chemotherapy (1 paper)
  • Molecules (1 paper)
  • Communications Biology (1 paper)

The scientist's research integrates aspects of cancer therapeutics and mechanisms, focusing on how DNA modifications and drug interactions affect cancer cells. Their work also encompasses molecular-level studies examining nucleic acid behavior and chemistry, as well as synthesis approaches to develop pharmacologically active compounds. This breadth of interrelated subjects reflects an ongoing engagement with both fundamental molecular biology and applied biomedical sciences.

Best Publications

  • DNA sequence dependent binding modes of 4',6-diamidino-2-phenylindole (DAPI).

    W D Wilson;F A Tanious;H J Barton;R L Jones

  • DNA structural variations produced by actinomycin and distamycin as revealed by DNAase I footprinting

    Keith R. Fox;Michael J. Waring

  • Influence of loop size on the stability of intramolecular DNA quadruplexes

    Antonina Risitano;Keith R. Fox

  • Site and sequence specificity of the daunomycin-DNA interaction.

    Jonathan B. Chaires;Keith R. Fox;Julio E. Herrera;Mark Britt

  • Targeting DNA with Triplexes

    Keith R. Fox

  • DNA sequence preferences of several AT-selective minor groove binding ligands.

    Anita Abu-Daya;Philip M. Brown;Keith R. Fox

  • High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler

    Richard A. J. Darby;Matthieu Sollogoub;Catherine McKeen;Lynda Brown

  • Towards mixed sequence recognition by triple helix formation

    Darren M. Gowers;Keith R. Fox

  • A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells

    Elena Miranda;Ida K. Nordgren;Abigail L. Male;Charlotte E. Lawrence

  • Stability of intramolecular DNA quadruplexes: comparison with DNA duplexes

    Antonina Risitano;Keith R Fox

  • Editorial: NAR Surveys the Past, Present and Future of Restriction Endonucleases

    William Dynan;Keith Fox;Barry Stoddard

  • Intramolecular DNA quadruplexes with different arrangements of short and long loops

    Phillip A. Rachwal;I. Stuart Findlow;Joern M. Werner;Tom Brown

  • Footprinting: a method for determining the sequence selectivity, affinity and kinetics of DNA-binding ligands.

    Andrew J Hampshire;David A Rusling;Victoria J Broughton-Head;Keith R Fox

  • Effect of G-tract length on the topology and stability of intramolecular DNA quadruplexes.

    Phillip A. Rachwal;Tom Brown;Keith R. Fox

  • Sequence effects of single base loops in intramolecular quadruplex DNA.

    Phillip A. Rachwal;Tom Brown;Keith R. Fox

  • Four base recognition by triplex-forming oligonucleotides at physiological pH

    David A. Rusling;Vicki E. C. Powers;Rohan T. Ranasinghe;Yang Wang

  • Drug-DNA interaction protocols

    Keith R. Fox

  • Investigations into the sequence-selective binding of mithramycin and related ligands to DNA

    Keith R. Fox;Nigel R. Howarth

  • Affinity of mismatch-binding protein MutS for heteroduplexes containing different mismatches.

    James Brown;Tom Brown;Keith R. Fox

  • Quadruplex melting.

    Unknown

  • Kinetics of dissociation of nogalamycin from DNA: comparison with other anthracycline antibiotics.

    Keith R. Fox;Cecilia Brassett;Michael J. Waring

Frequent Co-Authors

Tom Brown
Tom Brown University of Oxford
Michael J. Waring
Michael J. Waring University of Cambridge
Stephen Neidle
Stephen Neidle University College London
David E. Thurston
David E. Thurston King's College London
Lucjan Strekowski
Lucjan Strekowski Georgia State University
Barry L. Stoddard
Barry L. Stoddard Fred Hutchinson Cancer Research Center
John A. Hartley
John A. Hartley University College London
John Parkinson
John Parkinson University of Toronto
Dudley H. Williams
Dudley H. Williams University of Cambridge
Kenneth T. Douglas
Kenneth T. Douglas University of Manchester

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