John A. Hartley

Overview

Best Publications

• Tracking the Evolution of Non–Small-Cell Lung Cancer

  Mariam Jamal-Hanjani;Gareth A. Wilson;Nicholas McGranahan;Nicolai Juul Birkbak

  2216
  Citations

• Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

  Christopher Abbosh;Nicolai J. Birkbak;Nicolai J. Birkbak;Gareth A. Wilson;Gareth A. Wilson;Mariam Jamal-Hanjani

  1956
  Citations

• Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

  Nicholas McGranahan;Rachel Rosenthal;Crispin T. Hiley;Crispin T. Hiley;Andrew J. Rowan

  1320
  Citations

• Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England.

  Erik Volz;Swapnil Mishra;Meera Chand;Jeffrey C. Barrett

  1164
  Citations

• SARS-CoV-2 evolution during treatment of chronic infection.

  Steven A. Kemp;Dami A. Collier;Dami A. Collier;Rawlings P. Datir;Isabella A. T. M. Ferreira

  973
  Citations

• Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.

  Dami A. Collier;Dami A. Collier;Anna De Marco;Isabella A. T. M. Ferreira;Bo Meng

  656
  Citations

• Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells.

  U. De Silva;Peter J. Mchugh;Peter H. Clingen;John A. Hartley

  592
  Citations

• GC base sequence recognition by oligo(imidazolecarboxamide) and C-terminus-modified analogues of distamycin deduced from circular dichroism, proton nuclear magnetic resonance, and methidiumpropylethylenediaminetetraacetate-iron(II) footprinting studies

  Moses Lee;Andrea L. Rhodes;Michael D. Wyatt;Stephen Forrow

  577
  Citations

• Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

  Frederick Arce Vargas;Andrew J S Furness;Kevin Litchfield;Kroopa Joshi

  575
  Citations

• Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance

  Peter J McHugh;Victoria J Spanswick;John A Hartley

  513
  Citations

• Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.

  Frederick Arce Vargas;Andrew J.S. Furness;Andrew J.S. Furness;Isabelle Solomon;Kroopa Joshi;Kroopa Joshi

  457
  Citations

• Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.

  Bo Meng;Steven A Kemp;Steven A Kemp;Guido Papa;Rawlings Datir

  413
  Citations

• Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.

  Beate Köberle;John R.W. Masters;John A. Hartley;Richard D. Wood

  384
  Citations

• bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.

  T C Fisher;A E Milner;C D Gregory;A L Jackman

  339
  Citations

• Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.

  Stephen J. Gregson;Philip W. Howard;John A. Hartley;Natalie A. Brooks

  335
  Citations

• DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards

  William B. Mattes;John A. Hartley;Kurt W. Kohn

  333
  Citations

• EGFR Nuclear Translocation Modulates DNA Repair following Cisplatin and Ionizing Radiation Treatment

  Gianmaria Liccardi;John A. Hartley;Daniel Hochhauser

  322
  Citations

• Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards

  Kurt W. Kohn;John A. Hartley;William B. Mattes

  289
  Citations

• Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

  Khalid AbdulJabbar;Shan E. Ahmed Raza;Rachel Rosenthal;Rachel Rosenthal;Mariam Jamal-Hanjani;Mariam Jamal-Hanjani

  282
  Citations

• Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system

  D. Subhas Bose;Andrew S. Thompson;Jingshan Ching;John A. Hartley

  261
  Citations