World's Best Scientists 2026 revealed!
Te-Chang Lee

Te-Chang Lee

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
8609
World Ranking
14099
National Ranking
68

Overview

Te-Chang Lee is a researcher affiliated with Academia Sinica in Taiwan, with a focus on biochemistry, genetics, molecular biology, and medicine. Their work spans multiple subfields including cancer research, molecular biology, genetics, organic chemistry, and oncology.

Their research addresses key topics such as synthesis and reactivity of heterocycles, cancer therapeutics and mechanisms, RNA modifications and cancer, cancer hypoxia and metabolism, genetic associations and epidemiology, genomics and rare diseases, and cancer genomics and diagnostics.

Te-Chang Lee has contributed to various scientific publications. Notable recent papers include:

  • Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese, 2021, npj Genomic Medicine
  • Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives, 2020, European Journal of Medicinal Chemistry
  • Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links, 2021, Journal of Medicinal Chemistry
  • SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells, 2020, Cancers
  • GT-Repeat Polymorphism in the HO-1 Gene Promoter Is Associated with Risk of Liver Cancer: A Follow-Up Study from Arseniasis-Endemic Areas in Taiwan, 2021, Journal of Clinical Medicine

Their frequent co-authors include:

  • Tsann-Long Su
  • Kuo-Chu Lai
  • Vaikar Navakanth Rao
  • Anil S. Patel
  • Vicky Jain

Publications by Te-Chang Lee have appeared frequently in the following venues:

  • Cancer Research
  • npj Genomic Medicine
  • European Journal of Medicinal Chemistry
  • Journal of Medicinal Chemistry
  • Cancers

Overall, Te-Chang Lee's research activity centers on biochemistry, genetics, and molecular biology with a significant focus on cancer-related studies. Their investigations involve chemical synthesis related to anticancer compounds, genetic epidemiology, and molecular mechanisms underlying cancer and resistance to cancer treatments.

Best Publications

  • Gene expression of inflammatory molecules in circulating lymphocytes from arsenic-exposed human subjects.

    Meei-Maan Wu;Hung-Yi Chiou;I-Ching Ho;Chien-Jen Chen

  • Induction of gene amplification by arsenic

    Te-Chang Lee;N. Tanaka;P. W. Lamb;T. M. Gilmer

  • Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan.

    Meei Maan Wu;Hung Yi Chiou;Tsung Wei Wang;Yu Mei Hsueh

  • Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture

    Te-Chang Lee;Mitsuo Oshimura;J.Carl Barrett

  • Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese.

    Chun-Yu Wei;Jenn-Hwai Yang;Erh-Chan Yeh;Ming-Fang Tsai

  • Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts

    Te Chang Lee;I Ching Ho

  • Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts

    Ling-Huei Yih;Te-Chang Lee

  • Sodium arsenite enhances the cytotoxicity, clastogenicity, and 6-thioguanine-resistant mutagenicity of ultraviolet light in Chinese hamster ovary cells

    Te-Chang Lee;Ruea-Yea Huang;K.Y. Jan

  • Growth and differentiation of hamster tracheal epithelial cells in culture.

    Te-Chang Lee;R. Wu;A. R. Brody;J. C. Barrett

  • Oxidative Stress Mediates Sodium Arsenite-Induced Expression of Heme Oxygenase-1, Monocyte Chemoattractant Protein-1, and Interleukin-6 in Vascular Smooth Muscle Cells

    Pei-Chung Lee;I-Ching Ho;Te-Chang Lee

  • Isolation of four isotoxic proteins and one agglutinin from jequiriti bean (Abrus precatorius)

    Jung-Yaw Lin;Te-Chang Lee;Su-Tieng Hu;Ta-Cheng Tung

  • Elevation of glutathione levels and glutathione S-transferase activity in arsenic-resistant Chinese hamster ovary cells.

    T. C. Lee;M. L. Wei;W. J. Chang;I. C. Ho

  • Cellular Uptake of Trivalent Arsenite and Pentavalent Arsenate in KB Cells Cultured in Phosphate-Free Medium

    Rong-Nan Huang;Te-Chang Lee

  • Mechanisms of arsenic-induced cell transformation

    J C Barrett;P W Lamb;T C Wang;T C Lee

  • Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment.

    Ling-Huei Yih;Konan Peck;Te-Chang Lee

  • Sodium Arsenite Disturbs Mitosis and Induces Chromosome Loss in Human Fibroblasts

    Ling-Huei Yih;I-Ching Ho;Te-Chang Lee

  • Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates.

    Bhavin Marvania;Pei Chih Lee;Ravi Chaniyara;Ravi Chaniyara;Huajin Dong

  • Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers.

    K. W. Chang;T. C. Lee;W. I. Yeh;M. Y. Chung

  • Arsenite inhibits mitotic division and perturbs spindle dynamics in HeLa S3 cells.

    See-Chang Huang;Te-Chang Lee

  • Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma

    Pei-Fen Su;Te-Chang Lee;Pei-Ju Lin;Po-Huang Lee

Frequent Co-Authors

Chien-Jen Chen
Chien-Jen Chen Academia Sinica
Ting-Chao Chou
Ting-Chao Chou Memorial Sloan Kettering Cancer Center
Tung-Hu Tsai
Tung-Hu Tsai National Yang Ming University
Pan-Chyr Yang
Pan-Chyr Yang National Taiwan University
Cheng-Wen Wu
Cheng-Wen Wu National Yang Ming University
Alice L. Yu
Alice L. Yu University of California, San Diego
Shih-Hwa Chiou
Shih-Hwa Chiou National Yang Ming Chiao Tung University
Reen Wu
Reen Wu University of California, Davis
Paul Nettesheim
Paul Nettesheim National Institutes of Health
Chun-Yu Liu
Chun-Yu Liu Boston University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Te-Chang Lee

Trending Scientists

Recently Published Articles