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Chemistry

D-Index
59
Citations
9742
World Ranking
10387
National Ranking
590

Overview

David E. Thurston is affiliated with King's College London in the United Kingdom. Their research primarily focuses on Medicine, with a notable emphasis on Oncology, Radiology, Nuclear Medicine and Imaging, Molecular Biology, Organic Chemistry, and Genetics as subfields.

The scientist's main research topics include the exploration of HER2/EGFR in Cancer Research, Monoclonal and Polyclonal Antibodies Research, Cancer therapeutics and mechanisms, CAR-T cell therapy research, Synthesis and pharmacology of benzodiazepine derivatives, Chronic Lymphocytic Leukemia Research, and Multiple Myeloma Research and Treatments.

David E. Thurston's recent publications include:

  • Target Antigen Attributes and Their Contributions to Clinically Approved Antibody-Drug Conjugates (ADCs) in Haematopoietic and Solid Cancers, 2023, Cancers
  • A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma, 2020, Cancers
  • Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs), 2020, Scientific Reports
  • Anti-EGFR Antibody-Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth, 2024, Clinical Cancer Research
  • UPLC-based assay to assess the hydrophobicity of Antibody-Drug Conjugate (ADC) payloads, 2020, Journal of Chromatography B

Their frequent co-authors include Khondaker Miraz Rahman, Paul J. Jackson, Paolo Andriollo, George Procopiou, and Sophia N. Karagiannis. These collaborations have been sustained across multiple publications.

David E. Thurston has published in several venues with some frequency, primarily in Cancer Research, followed by Cancers, Scientific Reports, Clinical Cancer Research, and Haematologica.

Best Publications

  • A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

    Scott C. Jeffrey;Patrick J. Burke;Robert P. Lyon;David W. Meyer

  • Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.

    Stephen J. Gregson;Philip W. Howard;John A. Hartley;Natalie A. Brooks

  • Targeting protein–protein interactions for therapeutic intervention: a challenge for the future

    Giovanna Zinzalla;David E Thurston

  • Chemical approaches to the discovery and development of cancer therapies

    Stephen Neidle;David E. Thurston

  • Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).

    Dyeison Antonow;David E Thurston

  • From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).

    Julia Mantaj;Paul J. M. Jackson;Khondaker M. Rahman;David E. Thurston

  • Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system

    D. Subhas Bose;Andrew S. Thompson;Jingshan Ching;John A. Hartley

  • Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents.

    David E. Thurston;D. Subhas Bose;Andrew S. Thompson;Philip W. Howard

  • SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity: Part 1: Cellular Pharmacology, In vitro and Initial In vivo Antitumor Activity

    John A. Hartley;Victoria J. Spanswick;Natalie Brooks;Peter H. Clingen

  • Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

    Stephen J Gregson;Philip W Howard;Darren R Gullick;Anzu Hamaguchi

  • SYNTHESIS OF DNA-INTERACTIVE PYRROLO2,1-C1,4BENZODIAZEPINES

    Unknown

  • Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.

    Thurston De;Bose Ds;Howard Pw;Jenkins Tc

  • Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds.

    Laurence H. Hurley;Teri Reck;David E. Thurston;David R. Langley

  • Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs).

    Ricarda M Hoffmann;Ben G T Coumbe;Ben G T Coumbe;Debra H Josephs;Silvia Mele

  • Chemistry and Pharmacology of Anticancer Drugs

    David E. Thurston

  • Design, synthesis, and biophysical and biological evaluation of a series of Pyrrolobenzodiazepine - Poly(N-methylpyrrole) conjugates

    Geoff Wells;Christopher R H Martin;Philip W Howard;Zara A Sands

  • A versatile and efficient synthesis of carbinolamine-containing pyrrolo[1,4]benzodiazepines via the cyclization of N-(2-aminobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetals: total synthesis of prothracarcin

    David R. Langley;David E. Thurston

  • The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.

    Khondaker M. Rahman;Andrew S. Thompson;Colin H. James;Mathangi Narayanaswamy

  • Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking.

    Terence C. Jenkins;Laurence H. Hurley;Laurence H. Hurley;Stephen Neidle;Stephen Neidle;David E. Thurston;David E. Thurston

  • SJG-136 (NSC 694501), A Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity: Part 2: Efficacy Evaluations

    Michael C. Alley;Melinda G. Hollingshead;Christine M. Pacula-Cox;William R. Waud

  • Inhibition of bacteriophage T7 RNA polymerase in vitro transcription by DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines.

    Madhu S. Puvvada;Stephen A. Forrow;John A. Hartley;Pauline Stephenson

Frequent Co-Authors

John A. Hartley
John A. Hartley University College London
Stephen Neidle
Stephen Neidle University College London
Lloyd R. Kelland
Lloyd R. Kelland University College London
Laurence H. Hurley
Laurence H. Hurley University of Arizona
Keith R. Fox
Keith R. Fox University of Southampton
Pier Giovanni Baraldi
Pier Giovanni Baraldi University of Ferrara
Sophia N. Karagiannis
Sophia N. Karagiannis King's College London
Gary N. Parkinson
Gary N. Parkinson University College London
Andrew Tutt
Andrew Tutt Institute of Cancer Research
Nicoletta Bianchi
Nicoletta Bianchi University of Ferrara

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