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Chemistry

D-Index
64
Citations
10662
World Ranking
8246
National Ranking
2381

Research.com Recognitions

  • 2010 - Fellow of the American Chemical Society

Overview

Daniel L. Comins is affiliated with North Carolina State University in the United States. Their research primarily focuses on the field of chemistry, with particular emphasis on organic chemistry and molecular biology.

Their work encompasses several main topics, including:

  • Catalytic C-H Functionalization Methods
  • Catalytic Cross-Coupling Reactions
  • Chemical Synthesis and Analysis
  • Coordination Chemistry and Organometallics
  • Asymmetric Synthesis and Catalysis
  • Advanced Synthetic Organic Chemistry

Daniel L. Comins has published research in venues such as:

  • Molecules
  • ARKIVOC
  • UNC Libraries

Recent notable papers include:

  • Synthesis of MAPA Reagents and 2-Alkyl(aryl)aminopyridines from 2-Bromopyridine Using the Goldberg Reaction, 2022, published in Molecules
  • Preparation of substituted alkoxypyridines via directed metalation and metal-halogen exchange, 2021, published in ARKIVOC
  • Identification and Replication of Loci Involved in Camptothecin-Induced Cytotoxicity Using CEPH Pedigrees, 2020, published in UNC Libraries

Frequent collaborators in their research include:

  • Ibrahim D. Bori
  • Venita Gresham Watson
  • Alison A. Motsinger-Reif
  • Nicholas E. Hardison
  • Eric Peters

Throughout their career, Daniel L. Comins has contributed to multiple studies related to organic synthesis and catalyst development, often focusing on methodologies that enable precise functionalization of organic molecules.

In recognition of their contributions to the field of chemistry, Daniel L. Comins was named a Fellow of the American Chemical Society in 2010.

Best Publications

  • Pyridine-derived triflating reagents : an improved preparation of vinyl triflates from metallo enolates

    Daniel L. Comins;Ali Dehghani

  • Asymmetric synthesis of 2-alkyl(aryl)-2,3-dihydro-4-pyridones by addition of Grignard reagents to chiral 1-acyl-4-methoxypyridinium salts

    Daniel L. Comins;Sajan P. Joseph;R. Richard Goehring

  • Asymmetric synthesis of 3-substituted isoindolinones: application to the total synthesis of (+)-lennoxamine.

    Daniel L Comins;Stefan Schilling;Yanchen Zhang

  • ORTHO METALATION DIRECTED BY α-AMINO ALKOXIDES

    Daniel L. Comins;Jack D. Brown

  • A 10-step, asymmetric synthesis of (S)-camptothecin

    Daniel L. Comins;Matthew F. Baevsky;Hao Hong

  • N- vs. O-alkylation in the mitsunobu reaction of 2-pyridone

    Daniel L. Comins;Gao Jianhua

  • A practical six-step synthesis of (S)-camptothecin.

    Daniel L. Comins;Jason M. Nolan

  • A highly stereocontrolled, four-step synthesis of (.+-.)-lasubine II

    Jack D. Brown;Michael A. Foley;Daniel L. Comins

  • A six-step synthesis of (±) camptothecin

    Daniel L. Comins;Hao Hong;Jayanta K. Saha;Gao Jianhua

  • Lithiation of methoxypyridines directed by .alpha.-amino alkoxides

    Daniel L. Comins;Michael O. Killpack

  • Lithiation of heterocycles directed by .alpha.-amino alkoxides

    Daniel L. Comins;Michael O. Killpack

  • Asymmetric synthesis and synthetic utility of 2,3-dihydro-4-pyridones

    Daniel L. Comins

  • REGIOSELECTIVE ADDITION OF GRIGNARD REAGENTS TO 1-ACYLPYRIDINIUM SALTS. A CONVENIENT METHOD FOR THE SYNTHESIS OF 4-ALKYL(ARYL)PYRIDINES

    Unknown

  • Asymmetric synthesis of camptothecin alkaloids: A nine-step synthesis of (S)-camptothecin

    Daniel L. Comins;Hao Hong;Gao Jianhua

  • Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: Asymmetric Syntheses of Indolizidine Alkaloids (-)-205A, (-)-207A, and (-)-235B.

    Daniel L. Comins;Donald H. LaMunyon;Xinghai Chen

  • Efficient synthesis and resolution of trans-2-(1-aryl-1-methylethyl)cyclohexanols: practical alternatives to 8-phenylmenthol

    Daniel L. Comins;James M. Salvador

  • Enantiopure 2,3-dihydro-4-pyridones as synthetic intermediates. Asymmetric syntheses of the quinolizidine alkaloids, (+)-myrtine, (-)-lasubine I, and (+)-subcosine I

    Daniel L. Comins;Donald H. LaMunyon

  • DIASTEREOSELECTIVE ADDITION OF PROCHIRAL METALLO ENOLATES TO CHIRAL 1-ACYLPYRIDINIUM SALTS

    Daniel L. Comins;Jeffrey T. Kuethe;Hao Hong;Frederick J. Lakner

  • Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: Asymmetric Synthesis of (-)-Septicine and (-)-Tylophorine.

    Daniel L. Comins;Xinghai Chen;Lawrence A. Morgan

  • Total synthesis of (-)-maysine

    A. I. Meyers;K. A. Babiak;Arthur L. Campbell;Daniel L. Comins

  • Synthesis and Reactions of .alpha.-(Trifluoromethanesulfonyloxy) Enecarbamates Prepared from N-Acyllactams

    Christopher J. Foti;Daniel L. Comins

Frequent Co-Authors

David C. Muddiman
David C. Muddiman North Carolina State University
Michael Foley
Michael Foley La Trobe University
Thomas C. Sparks
Thomas C. Sparks Dow Chemical (United States)
Alexander Deiters
Alexander Deiters University of Pittsburgh
Coby Schal
Coby Schal North Carolina State University
Arnold L. Rheingold
Arnold L. Rheingold University of California, San Diego
Howard L. McLeod
Howard L. McLeod Utah Tech University
John C. Burnett
John C. Burnett Mayo Clinic

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