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Chemistry

D-Index
69
Citations
17730
World Ranking
6162
National Ranking
204

Overview

Alain Beck is affiliated with the University of Strasbourg in France and has contributed extensively to the fields of biochemistry, medicine, and chemistry. Their research spans 36 publications in biochemistry, genetics, and molecular biology, 35 in medicine, and 23 in chemistry. Within these fields, their focus includes molecular biology, radiology, nuclear medicine and imaging, spectroscopy, oncology, and biomedical engineering.

Their main research topics cover protein purification and stability, with 52 publications in this area, and monoclonal and polyclonal antibodies research, comprising 46 publications. They have also worked on analytical chemistry and chromatography, mass spectrometry techniques and applications, viral infectious diseases and gene expression in insects, microfluidic and capillary electrophoresis applications, and HER2/EGFR in cancer research.

Beck has published in a range of journals, frequently appearing in Analytical Chemistry (6 publications), Journal of Pharmaceutical and Biomedical Analysis (4 publications), Journal of Chromatography A (4 publications), Pharmaceuticals (2 publications), and Journal of the American Society for Mass Spectrometry (2 publications).

Their recent significant papers include:

  • Antibody-drug conjugates come of age in oncology, 2023, Nature Reviews Drug Discovery
  • Antibody-Drug Conjugates: The Last Decade, 2020, Pharmaceuticals
  • Therapeutic Fc-fusion proteins: Current analytical strategies, 2020, Journal of Separation Science
  • Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry, 2020, Journal of the American Society for Mass Spectrometry
  • Combination of intact, middle-up and bottom-up levels to characterize 7 therapeutic monoclonal antibodies by capillary electrophoresis - Mass spectrometry, 2020, Journal of Pharmaceutical and Biomedical Analysis

Frequent co-authors in their publications include Davy Guillarme (18 collaborations), Sarah Cianférani (13 collaborations), Valentina D'Atri (11 collaborations), Szabolcs Fekete (9 collaborations), and Olivier Colas (8 collaborations).

Best Publications

  • Strategies and challenges for the next generation of antibody–drug conjugates

    Alain Beck;Liliane Goetsch;Charles Dumontet;Nathalie Corvaïa

  • Strategies and challenges for the next generation of therapeutic antibodies

    Alain Beck;Thierry Wurch;Christian Bailly;Nathalie Corvaia

  • Antibody–drug conjugates come of age in oncology

    Unknown

  • Characterization of Therapeutic Antibodies and Related Products

    Alain Beck;Elsa Wagner-Rousset;Daniel Ayoub;Alain Van Dorsselaer

  • Theory and practice of size exclusion chromatography for the analysis of protein aggregates.

    Szabolcs Fekete;Alain Beck;Jean-Luc Veuthey;Davy Guillarme

  • Antibody-Drug Conjugates: The Last Decade.

    Nicolas Joubert;Alain Beck;Charles Dumontet;Caroline Denevault-Sabourin

  • A recombinant humanized anti‐insulin‐like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti‐epidermal growth factor receptor therapy against human cancer xenografts

    Liliane Goetsch;Alexandra Gonzalez;Olivier Leger;Alain Beck

  • Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins.

    Alain Beck;Elsa Wagner-Rousset;Marie-Claire Bussat;Maryline Lokteff

  • Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry

    Alain Beck;Sarah Sanglier-Cianférani;Alain Van Dorsselaer

  • Ion-exchange chromatography for the characterization of biopharmaceuticals

    Szabolcs Fekete;Alain Beck;Jean-Luc Veuthey;Davy Guillarme

  • Structure, heterogeneity and developability assessment of therapeutic antibodies

    Yingda Xu;Dongdong Wang;Bruce Mason;Tony Rossomando

  • Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody.

    Josef Vlasak;Marie C. Bussat;Shiyi Wang;Elsa Wagner-Rousset

  • Forced degradation of recombinant monoclonal antibodies: A practical guide.

    Christine Nowak;Jason K. Cheung;Shara M. Dellatore;Amit Katiyar

  • Determination of isoelectric points and relative charge variants of 23 therapeutic monoclonal antibodies.

    Alexandre Goyon;Melissa Excoffier;Marie Claire Janin-Bussat;Balazs Bobaly

  • Marketing approval of mogamulizumab: A triumph for glyco-engineering

    Alain Beck;Janice M. Reichert

  • Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part II: pH gradient approach

    Szabolcs Fekete;Alain Beck;Jenő Fekete;Davy Guillarme

  • Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry

    Luca Fornelli;Daniel Ayoub;Konstantin Aizikov;Alain Beck

  • Innovative Native MS Methodologies for Antibody Drug Conjugate Characterization: High Resolution Native MS and IM-MS for Average DAR and DAR Distribution Assessment

    François Debaene;François Debaene;Amandine Bœuf;Elsa Wagner-Rousset;Olivier Colas

  • Therapeutic Fc-fusion proteins and peptides as successful alternatives to antibodies.

    Alain Beck;Janice M Reichert

  • The next generation of antibody-drug conjugates comes of age.

    Alain Beck;Jean-François Haeuw;Thierry Wurch;Liliane Goetsch

  • Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques.

    Daniel Ayoub;Wolfgang Jabs;Anja Resemann;Waltraud Evers

  • Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cells

    Alain Beck;Marie-Claire Bussat;Nathalie Zorn;Virginie Robillard

  • Hydrophobic interaction chromatography for the characterization of monoclonal antibodies and related products

    Szabolcs Fekete;Jean-Luc Veuthey;Alain Beck;Davy Guillarme

  • Analytical characterization of biosimilar antibodies and Fc-fusion proteins

    Alain Beck;Hélène Diemer;Daniel Ayoub;François Debaene

  • Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine‐linked antibody drug conjugate

    Julien Marcoux;Julien Marcoux;Thierry Champion;Olivier Colas;Elsa Wagner-Rousset

  • Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies.

    Alain Beck;François Debaene;Hélène Diemer;Elsa Wagner-Rousset

  • Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion

    Elsa Wagner-Rousset;Marie-Claire Janin-Bussat;Olivier Colas;Melissa Excoffier

  • Development of Comprehensive Online Two-Dimensional Liquid Chromatography/Mass Spectrometry Using Hydrophilic Interaction and Reversed-Phase Separations for Rapid and Deep Profiling of Therapeutic Antibodies.

    Dwight R. Stoll;David C. Harmes;Gregory O. Staples;Oscar G. Potter

Frequent Co-Authors

Davy Guillarme
Davy Guillarme University of Geneva
Szabolcs Fekete
Szabolcs Fekete University of Geneva
Alain Van Dorsselaer
Alain Van Dorsselaer University of Strasbourg
Jean-Luc Veuthey
Jean-Luc Veuthey University of Geneva
Jean-Yves Bonnefoy
Jean-Yves Bonnefoy Salto Therapeutics
Alexey Lugovskoy
Alexey Lugovskoy Biogen (United States)
Alexander Makarov
Alexander Makarov Thermo Fisher Scientific (Israel)
Pavel A. Pevzner
Pavel A. Pevzner University of California, San Diego
Frank Sobott
Frank Sobott University of Leeds
Bernard Verrier
Bernard Verrier Claude Bernard University Lyon 1

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