Alexey Lugovskoy

Overview

Best Publications

• Identification of RIP1 kinase as a specific cellular target of necrostatins.

  Alexei Degterev;Junichi Hitomi;Megan Germscheid;Irene L Ch'en

  2316
  Citations

• Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL.

  Alexei Degterev;Alexey Lugovskoy;Michael Cardone;Bradley Mulley

  799
  Citations

• The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor

  Or Gozani;Philip Karuman;David R. Jones;Dmitri Ivanov

  652
  Citations

• Small-Molecule Inhibition of TNF-α

  Molly M. He;Annemarie Stroustrup Smith;Johan D. Oslob;William M. Flanagan

  559
  Citations

• Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E

  John D. Gross;Nathan J. Moerke;Tobias von der Haar;Alexey A. Lugovskoy

  437
  Citations

• Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36.

  Xiaobing Shi;Ioulia Kachirskaia;Kay L. Walter;Jen Hao A. Kuo

  352
  Citations

• Identification and Characterization of Mefloquine Efficacy against JC Virus In Vitro

  Margot Brickelmaier;Alexey Lugovskoy;Ramya Kartikeyan;Marta M. Reviriego-Mendoza

  243
  Citations

• Stabilized polypeptide compositions

  Stephen Demarest;Scott Glaser;Brian Robert Miller;Xiufeng Wu

  242
  Citations

• Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.

  Douglas Marcotte;Weike Zeng;Jean-Christophe Hus;Andres McKenzie

  237
  Citations

• Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

  Louis A. Clark;P. Ann Boriack-Sjodin;John Eldredge;Christopher Fitch

  217
  Citations

• A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins.

  Pei Zhou;Alexey A. Lugovskoy;Gerhard Wagner

  207
  Citations

• Processing of Anti-Müllerian Hormone Regulates Receptor Activation by a Mechanism Distinct from TGF-β

  Nathalie di Clemente;Soazik P. Jamin;Alexey Lugovskoy;Paul Carmillo

  179
  Citations

• Progressive Multifocal Leukoencephalopathy (PML) Development Is Associated With Mutations in JC Virus Capsid Protein VP1 That Change Its Receptor Specificity

  Leonid Gorelik;Carl Reid;Manuela Testa;Margot Brickelmaier

  169
  Citations

• Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains

  Benchun Miao;Igor Skidan;Jinsheng Yang;Alexey Lugovskoy

  168
  Citations

• A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors.

  Alexey A Lugovskoy;Alexei I Degterev;Amr F Fahmy;Pei Zhou

  167
  Citations

• Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site.

  Mia Rushe;Laura Silvian;Sarah Bixler;Ling Ling Chen

  164
  Citations

• Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

  Pascal Schneider;Dian Olson;Aubry Tardivel;Beth Browning

  163
  Citations

• Adaptive Mutations in the JC Virus Protein Capsid Are Associated with Progressive Multifocal Leukoencephalopathy (PML)

  Shamil R. Sunyaev;Shamil R. Sunyaev;Alexey Lugovskoy;Kenneth Simon;Leonid Gorelik

  153
  Citations

• Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR.

  Jennifer S. Michaelson;Stephen J. Demarest;Brian Miller;Aldo Amatucci

  149
  Citations

• Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at

  Xiaobing Shi;Ioulia Kachirskaia;Kay L. Walter;Jen-Hao A. Kuo

  0
  Citations