World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
16987
World Ranking
9549
National Ranking
4215

Overview

R. Blake Pepinsky is affiliated with Biogen in the United States and conducts research primarily within the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine.

The scientist's work has been published in notable venues including mAbs and the Journal of Biological Chemistry. Their research encompasses several specialized subfields such as Molecular Biology, Immunology and Allergy, Cell Biology, Endocrinology, Diabetes and Metabolism, and Genetics.

Major topics addressed in their research include Cell Adhesion Molecules Research, Proteoglycans and Glycosaminoglycans Research, Glycosylation and Glycoproteins Research, Growth Hormone and Insulin-like Growth Factors, Genetic Syndromes and Imprinting, and PI3K/AKT/mTOR signaling in cancer.

Among recent scholarly contributions are:

  • Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site (2020), published in mAbs
  • The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor (2021), published in Journal of Biological Chemistry

Frequent collaborators in research projects include Karl J. M. Hanf, Joseph W. Arndt, Yuting Liu, Bang Jian Gong, and Mia Rushe. These collaborations reflect interdisciplinary partnerships contributing to the scientist's published outputs.

Best Publications

  • LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.

    Sha Mi;Xinhua Lee;Zhaohui Shao;Greg Thill

  • Identification of a palmitic acid-modified form of human Sonic hedgehog.

    R. B. Pepinsky;Chenhui Zeng;Dingyi Wen;P. Rayhorn

  • Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity.

    Barbara P. Wallner;Robert J. Mattaliano;Catherine Hession;Richard L. Cate

  • LINGO-1 negatively regulates myelination by oligodendrocytes.

    Sha Mi;Robert H Miller;Xinhua Lee;Martin L Scott

  • The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

    Roberto Pola;Leona E. Ling;Marcy Silver;Michael J. Corbley

  • Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase

    Kuo-Sen Huang;Barbara P. Wallner;Robert J. Mattaliano;Richard Tizard

  • TAJ/TROY, an Orphan TNF Receptor Family Member, Binds Nogo-66 Receptor 1 and Regulates Axonal Regeneration

    Zhaohui Shao;Jeffrey L. Browning;Xinhua Lee;Martin L. Scott

  • Five distinct calcium and phospholipid binding proteins share homology with lipocortin I.

    R B Pepinsky;R Tizard;R J Mattaliano;L K Sinclair

  • Epidermal growth factor-dependent phosphorylation of lipocortin

    R. Blake Pepinsky;Lesley K. Sinclair

  • Nucleic acids encoding and methods of making tat-derived transport polypeptides

    Alan Frankel;Carl Pabo;James G. Barsoum;Stephen E. Fawell

  • Comparative biological responses to human Sonic, Indian, and Desert hedgehog.

    Suji Pathi;Sylvia Pagan-Westphal;Darren P Baker;Ellen A Garber

  • Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses

    K c Lin;H S Ateeq;S H Hsiung;L T Chong

  • Tat-derived transport polypeptides and fusion proteins

    Alan Frankel;Carl Pabo;James G. Barsoum;Stephen E. Fawell

  • Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test.

    G Cirino;S H Peers;R J Flower;J L Browning

  • Tat-derived transport polypeptides

    James G. Barsoum;Stephen E. Fawell;R. Blake Pepinsky

  • Purification and partial sequence analysis of a 37-kDa protein that inhibits phospholipase A2 activity from rat peritoneal exudates.

    R B Pepinsky;L K Sinclair;J L Browning;R J Mattaliano

  • GFRalpha3 is expressed predominantly in nociceptive sensory neurons

    Olivia E. Orozco;Lee Walus;Dinah W. Y. Sah;R. Blake Pepinsky

  • NGF Regulates the Expression of Axonal LINGO-1 to Inhibit Oligodendrocyte Differentiation and Myelination

    Xinhua Lee;Zhongshu Yang;Zhaohui Shao;Sheila S. Rosenberg

  • LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury.

    Benxiu Ji;Mingwei Li;Wu-Tian Wu;Leung-Wah Yick

  • Enhanced potency of human Sonic hedgehog by hydrophobic modification.

    Frederick R. Taylor;Dingyi Wen;Ellen A. Garber;Amie N. Carmillo

Frequent Co-Authors

Alexey Lugovskoy
Alexey Lugovskoy Biogen (United States)
Jeffrey L. Browning
Jeffrey L. Browning Boston University
Paul H. Weinreb
Paul H. Weinreb Biogen (United States)
Roy R. Lobb
Roy R. Lobb Biogen (United States)
Wutian Wu
Wutian Wu University of Hong Kong
Kwok-Fai So
Kwok-Fai So University of Hong Kong
William O. Whetsell
William O. Whetsell Vanderbilt University Medical Center
Graham Carpenter
Graham Carpenter Vanderbilt University

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