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D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
21061
World Ranking
8992
National Ranking
3995

Overview

Roy R. Lobb is affiliated with Biogen in the United States. Their research primarily focuses on medical and biochemical fields, with specializations in oncology, molecular biology, genetics, immunology, and organic chemistry.

The scientist's work covers several main research topics:

  • CAR-T cell therapy research
  • Virus-based gene therapy research
  • Viral Infectious Diseases and Gene Expression in Insects
  • Biosimilars and Bioanalytical Methods
  • Enzyme function and inhibition
  • Peptidase Inhibition and Analysis
  • Click Chemistry and Applications

Roy R. Lobb has contributed to multiple peer-reviewed papers, including:

  • "Anti-CD19 CAR T cells potently redirected to kill solid tumor cells," 2021, published in PLoS ONE
  • "Engineered protein-small molecule conjugates empower selective enzyme inhibition," 2021, published in Cell chemical biology
  • "Engineered protein-small molecule conjugates empower selective enzyme inhibition," 2021, published in bioRxiv (Cold Spring Harbor Laboratory)
  • "CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphoma," 2022, published in OncoImmunology
  • "A CD19-Anti-ErbB2 scFv Engager Protein Enables CD19-Specific CAR T Cells to Eradicate ErbB2+ Solid Cancer," 2023, published in Cells

The scientist frequently publishes in venues such as Regular and Young Investigator Award Abstracts, bioRxiv (Cold Spring Harbor Laboratory), PLoS ONE, Cell chemical biology, and OncoImmunology.

Frequent co-authors collaborating with Roy R. Lobb include:

  • Paul D. Rennert
  • Christine Ambrose
  • Lihe Su
  • Lan Wu
  • Benjamin J. Hackel

The publications reflect a sustained contribution to the oncology domain and related molecular biology studies. The work on CAR-T cell therapy is particularly prominent, showing a focus on developing and optimizing cellular therapies for cancer treatment. Research on enzyme inhibition and small molecule conjugates further highlights interest in molecular mechanisms and therapeutic targeting.

Best Publications

  • Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes.

    Laurelee Osborn;Catherine Hession;Richard Tizard;Cornelia Vassallo

  • VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

    Mariano J. Elices;Laurelee Osborn;Yoshikazu Takada;Carol Crouse

  • Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets.

    Theresa Palabrica;Roy Lobb;Barbara C. Furie;Mark Aronovitz

  • The pathophysiologic role of alpha 4 integrins in vivo.

    R R Lobb;M E Hemler

  • Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody.

    D K Podolsky;R Lobb;N King;C D Benjamin

  • ELFT: a gene that directs the expression of an ELAM-1 ligand.

    Susan E. Goelz;Catherine Hession;Deborah Goff;Beth Griffiths

  • Amino acid sequence of human tumor derived angiogenin.

    Strydom Dj;Fett Jw;Lobb Rr;Alderman Em

  • Subsecond Induction of α4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions

    Valentin Grabovsky;Sara Feigelson;Chun Chen;Diederik A. Bleijs

  • Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, alpha m beta 2) on human neutrophils.

    S K Lo;S Lee;R A Ramos;R Lobb

  • Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1

    T Carlos;N Kovach;B Schwartz;M Rosa

  • Purification of heparin-binding growth factors.

    R. R. Lobb;J. W. Harper;J. W. Fett;J. W. Fett

  • Purification and characterization of heparin-binding endothelial cell growth factors.

    Roy Lobb;Joachim Sasse;Robert Sullivan;Yuen Shing

  • Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep.

    W M Abraham;M W Sielczak;A Ahmed;A Cortes

  • Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1.

    Peter F. Weller;Thomas H. Rand;Susan E. Goelz;Gloria Chi-Rosso

  • Expression of vascular adhesion molecules in inflammatory bowel disease.

    Mitsuru Koizumi;Norval King;Roy Lobb;Christopher Benjamin

  • Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes.

    Rafael Pulido;Mariano J. Elices;Miguel R. Campanero;Laurelee Osborn

  • Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis

    Antonin R. de Fougerolles;Andrew G. Sprague;Cheryl L. Nickerson-Nutter;Gloria Chi-Rosso

  • Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses

    K c Lin;H S Ateeq;S H Hsiung;L T Chong

  • VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis.

    Miquel Sans;Julián Panés;Esther Ardite;J.Ignasi Elizalde

  • Heparin potentiates the action of acidic fibroblast growth factor by prolonging its biological half-life.

    Deborah H. Damon;Roy R. Lobb;Patricia A. D'Amore;John A. Wagner

Frequent Co-Authors

Linda C. Burkly
Linda C. Burkly Biogen (United States)
Christine Ambrose
Christine Ambrose Biogen (United States)
Martin E. Hemler
Martin E. Hemler Harvard University
R. Blake Pepinsky
R. Blake Pepinsky Biogen (United States)
Sussan Nourshargh
Sussan Nourshargh Queen Mary University of London
Ronen Alon
Ronen Alon Weizmann Institute of Science
James F. Riordan
James F. Riordan Harvard University
Daniel K. Podolsky
Daniel K. Podolsky The University of Texas at Dallas
Bert L. Vallee
Bert L. Vallee Harvard University
Juan J. Calvete
Juan J. Calvete Spanish National Research Council

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