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Biology and Biochemistry

D-Index
55
Citations
13207
World Ranking
14893
National Ranking
6236

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Liangyou Rui is a researcher affiliated with the University of Michigan-Ann Arbor in the United States. Their research focuses primarily on biochemistry, genetics, molecular biology, and medicine, with 38 publications in each of these main fields. The scientist's work spans multiple subfields including molecular biology, physiology, cancer research, epidemiology, and endocrine and autonomic systems.

The main topics of research include adipose tissue and metabolism, regulation of appetite and obesity, liver disease diagnosis and treatment, RNA modifications and cancer, epigenetics and DNA methylation, endoplasmic reticulum stress and disease, as well as liver physiology and pathology.

Liangyou Rui has contributed to a number of scientific papers. Some recent publications are:

  • Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease, 2020, Nature Communications
  • Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes, 2020, Journal of Clinical Investigation
  • Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis, 2022, Nature Metabolism
  • Reprogramming of Hepatic Metabolism and Microenvironment in Nonalcoholic Steatohepatitis, 2022, Annual Review of Nutrition
  • Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice, 2022, Nature Communications

The frequent publication venues for Liangyou Rui include:

  • Diabetes
  • Nature Communications
  • Advanced Science
  • Journal of Clinical Investigation
  • Nature Metabolism

Frequent co-authors collaborating with Liangyou Rui are:

  • Lin Jiang
  • Min-Hyun Kim
  • Zhiguo Zhang
  • Xiao Yan Zhong
  • Hong Shen

Liangyou Rui was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2018.

Best Publications

  • Energy metabolism in the liver

    Liangyou Rui

  • SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2.

    Liangyou Rui;Minsheng Yuan;Daniel Frantz;Steven Shoelson

  • Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

    Liangyou Rui;Vincent Aguirre;Jason K. Kim;Gerald I. Shulman

  • Recent advances in understanding leptin signaling and leptin resistance

    David L. Morris;Liangyou Rui

  • Leptin signaling and leptin resistance.

    Yingjiang Zhou;Liangyou Rui

  • The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity

    Bo Shan;Xiaoxia Wang;Ying Wu;Chi Xu

  • Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice.

    Decheng Ren;Minghua Li;Chaojun Duan;Liangyou Rui

  • Neuronal SH2B1 is essential for controlling energy and glucose homeostasis

    Decheng Ren;Yingjiang Zhou;David Morris;Minghua Li

  • Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

    Liangyou Rui;Tracey L. Fisher;Jeffrey Thomas;Morris F. White

  • Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice†

    Qiong Wang;Lei Jiang;Jue Wang;Shoufeng Li

  • Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling.

    L Rui;L S Mathews;K Hotta;T A Gustafson

  • Human SH2B1 mutations are associated with maladaptive behaviors and obesity

    Michael E. Doche;Elena G. Bochukova;Hsiao Wen Su;Laura R. Pearce

  • SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin

    Chaojun Duan;Minghua Li;Liangyou Rui

  • Identification of SH2-Bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2

    Liangyou Rui;Christin Carter-Su

  • Brown and Beige Adipose Tissues in Health and Disease.

    Liangyou Rui

  • Identification of MUP1 as a regulator for glucose and lipid metabolism in mice.

    Yingjiang Zhou;Lin Jiang;Liangyou Rui

  • Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling

    Mengle Shao;Bo Shan;Yang Liu;Yiping Deng

  • Disruption of the SH2-B Gene Causes Age-Dependent Insulin Resistance and Glucose Intolerance

    Chaojun Duan;Hongyan Yang;Morris F. White;Liangyou Rui

  • Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding.

    Xin Tong;Marina Muchnik;Zheng Chen;Manish Patel

  • SH2-B is required for nerve growth factor-induced neuronal differentiation.

    Liangyou Rui;James Herrington;Christin Carter-Su

Frequent Co-Authors

Christin Carter-Su
Christin Carter-Su University of Michigan–Ann Arbor
Morris F. White
Morris F. White Boston Children's Hospital
Inês Barroso
Inês Barroso University of Exeter
Yatrik M. Shah
Yatrik M. Shah University of Michigan–Ann Arbor
David L. Morris
David L. Morris University of New South Wales
I. Sadaf Farooqi
I. Sadaf Farooqi University of Cambridge
Ying Wu
Ying Wu Northwestern University
M. Bishr Omary
M. Bishr Omary University of Michigan–Ann Arbor
Wen-Jun Li
Wen-Jun Li Sun Yat-sen University
Stephen O'Rahilly
Stephen O'Rahilly University of Cambridge

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