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Gökhan S. Hotamisligil

Gökhan S. Hotamisligil

D-Index & Metrics

Medicine

D-Index
126
Citations
129952
World Ranking
2866
National Ranking
1594

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Gökhan S. Hotamisligil is affiliated with Harvard University in the United States. Their research spans multiple fields, primarily focusing on Medicine and Biochemistry, Genetics and Molecular Biology. Within these areas, Hotamisligil's work involves subfields such as Molecular Biology, Physiology, Epidemiology, Cell Biology, and Surgery.

The scientist's research topics include:

  • Adipose Tissue and Metabolism
  • Mitochondrial Function and Pathology
  • Adipokines, Inflammation, and Metabolic Diseases
  • Peroxisome Proliferator-Activated Receptors
  • Liver Disease Diagnosis and Treatment
  • Endoplasmic Reticulum Stress and Disease
  • Diet and metabolism studies

Frequently publishing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cell Metabolism, Nature, Nature Metabolism, and Nature Communications, Hotamisligil has contributed to advancing understanding in metabolism and cellular biology.

Notable recent publications include:

  • "Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity," 2024, Nature Communications
  • "Regulation of liver subcellular architecture controls metabolic homeostasis," 2022, Nature
  • "Metabolic Messengers: tumour necrosis factor," 2021, Nature Metabolism
  • "A hormone complex of FABP4 and nucleoside kinases regulates islet function," 2021, Nature
  • "Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism," 2020, Cell Metabolism

Frequent coauthors collaborating with Hotamisligil include:

  • Karen Inouye
  • Grace Yankun Lee
  • Ana Paula Arruda
  • Güneş Parlakgül
  • Gürol Tuncman

Hotamisligil's work has been recognized by their peers, as indicated by their status as a Fellow of the American Association for the Advancement of Science (AAAS), awarded in 2009.

Best Publications

  • Inflammation and metabolic disorders

    Gökhan S. Hotamisligil

  • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

    Gökhan S. Hotamisligil;Narinder S. Shargill;Bruce M. Spiegelman

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Inflammation, stress, and diabetes

    Kathryn E. Wellen;Gökhan S. Hotamisligil

  • Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

    Umut Özcan;Qiong Cao;Erkan Yilmaz;Ann-Hwee Lee

  • Inflammatory Mechanisms in Obesity

    Margaret F. Gregor;Gökhan S. Hotamisligil

  • A central role for JNK in obesity and insulin resistance

    Jiro Hirosumi;Gürol Tuncman;Lufen Chang;Cem Z. Görgün

  • IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

    Gökhan S. Hotamisligil;Pascal Peraldi;Adriane Budavari;Ramsey Ellis

  • Protection from obesity-induced insulin resistance in mice lacking TNF-|[alpha]| function

    K T Uysal;S M Wiesbrock;M W Marino;G S Hotamisligil

  • Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

    Gökhan S. Hotamisligil

  • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.

    Umut Özcan;Erkan Yilmaz;Lale Özcan;Masato Furuhashi

  • Obesity-induced inflammatory changes in adipose tissue

    Kathryn E. Wellen;Gökhan S. Hotamisligil

  • Plasma adiponectin levels and risk of myocardial infarction in men

    T Pischon;C.J Girman;G.S Hotamisligil;N Rifai

  • Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

    Kristin M Nieman;Hilary A Kenny;Carla V Penicka;Andras Ladanyi

  • Inflammation, metaflammation and immunometabolic disorders

    Gökhan S. Hotamisligil

  • Tumor necrosis factor alpha: a key component of the obesity-diabetes link.

    Gökhan S Hotamisligil;Bruce M Spiegelman

  • Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets.

    Masato Furuhashi;Gökhan S. Hotamisligil

  • Tumor necrosis factor alpha inhibits signaling from the insulin receptor

    Gokhan S. Hotamisligil;David L. Murray;Lisa N. Choy;Bruce M. Spiegelman

  • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

    Ling Yang;Ping Li;Suneng Fu;Ediz S. Calay

  • Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

    Haiming Cao;Kristin Gerhold;Jared R. Mayers;Michelle M. Wiest

Frequent Co-Authors

Eric B. Rimm
Eric B. Rimm Harvard University
Bruce M. Spiegelman
Bruce M. Spiegelman Harvard University
Nader Rifai
Nader Rifai Boston Children's Hospital
MacRae F. Linton
MacRae F. Linton Vanderbilt University
Tobias Pischon
Tobias Pischon Max Delbrück Center for Molecular Medicine
Sergio Fazio
Sergio Fazio Oregon Health & Science University
Xandra O. Breakefield
Xandra O. Breakefield Harvard University
Dariush Mozaffarian
Dariush Mozaffarian Tufts University
Brendan D. Manning
Brendan D. Manning Harvard University
Barbara B. Kahn
Barbara B. Kahn Beth Israel Deaconess Medical Center

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