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Andrea Vasella

Andrea Vasella

D-Index & Metrics

Chemistry

D-Index
68
Citations
15551
World Ranking
6566
National Ranking
132

Overview

Andrea Vasella is affiliated with ETH Zurich in Switzerland and has contributed extensively to research in biochemistry, genetics, molecular biology, chemistry, and medicine. Their work spans multiple subfields including molecular biology, organic chemistry, infectious diseases, molecular medicine, and pharmacology.

Their research has focused on key topics such as RNA and protein synthesis mechanisms, carbohydrate chemistry and synthesis, antimicrobial resistance in Staphylococcus, antibiotic resistance in bacteria, glycosylation and glycoproteins research, microbial natural products and biosynthesis, and antimicrobial peptides and activities.

Frequent coauthors collaborating with Vasella include David Crich, Sven N. Hobbie, Klara Haldimann, Erik C. Böttger, and Marina Gysin.

Andrea Vasella's work has been published predominantly in the following venues:

  • ChemMedChem
  • ACS Infectious Diseases
  • The Journal of Organic Chemistry
  • Carbohydrate Research
  • RSC Medicinal Chemistry

Selected recent papers authored or coauthored by Andrea Vasella include:

  • An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity (2020, ChemMedChem)
  • Structure-Activity Relationships for 5'' Modifications of 4,5-Aminoglycoside Antibiotics (2022, ChemMedChem)
  • Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site (2020, The Journal of Organic Chemistry)
  • Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5''- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes (2021, ACS Infectious Diseases)
  • Synthesis of a Pseudodisaccharide Suitable for Synthesis of Ring I Modified 4,5-2-Deoxystreptamine Type Aminoglycoside Antibiotics (2020, The Journal of Organic Chemistry)

Best Publications

  • Recent Insights into Inhibition, Structure, and Mechanism of Configuration-Retaining Glycosidases.

    Tom D. Heightman;Andrea T. Vasella

  • Carbocyclische Verbindungen aus Monosacchariden. II. Umsetzungen in der Mannosereihe

    Bruno Bernet;Andrea Vasella

  • A Structural View of the Action of Escherichia Coli (Lacz) Beta-Galactosidase

    Douglas H. Juers;Tom D. Heightman;Andrea Vasella;John D. McCarter

  • High resolution X-ray crystallography shows that ascorbate is a cofactor for myrosinase and substitutes for the function of the catalytic base.

    Wilhelm Pascal Burmeister;Sylvain Cottaz;Patrick Rollin;Andrea Vasella

  • Glycosidase mechanisms.

    Unknown

  • Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.

    Tanja Matt;Chyan Leong Ng;Chyan Leong Ng;Kathrin Lang;Su Hua Sha;Su Hua Sha

  • Convenient Synthesis of 2‐Azido‐2‐deoxy‐aldoses by Diazo Transfer

    Andrea Vasella;Christian Witzig;Jose-Luis Chiara;Manuel Martin-Lomas

  • Fullerene Sugars: Preparation of Enantiomerically Pure, Spiro‐Linked C‐Glycosides of C60

    Andrea Vasella;Peter Uhlmann;Christian A. A. Waldraff;François Diederich

  • N-acetylglucosaminono-1,5-lactone oxime and the corresponding (phenylcarbamoyl)oxime. Novel and potent inhibitors of beta-N-acetylglucosaminidase.

    Markus Horsch;Lienhard Hoesch;Andrea Vasella;Dora M. Rast

  • The active site of cellobiohydrolase Cel6A from Trichoderma reesei: the roles of aspartic acids D221 and D175.

    Anu Koivula;Laura Ruohonen;G. Wohlfahrt;Tapani Reinikainen

  • Structural determinants of substrate specificity in family 1 beta-glucosidases: novel insights from the crystal structure of sorghum dhurrinase-1, a plant beta-glucosidase with strict specificity, in complex with its natural substrate.

    Lionel Verdoucq;Jeanne Morinière;David R. Bevan;Asim Esen

  • Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.

    Tracey M. Gloster;Peter Meloncelli;Robert V. Stick;David Zechel

  • Stereoselektivität und Reaktivität bei der 1,3‐dipolaren Cycloaddition chiraler N‐(Alkoxyalkyl)nitrone

    Andrea Vasella

  • Deoxy‐nitrosugars. 6th communication. Stereoelectronic control in the reductive denitration of tertiary nitro ethers. A synthesis of ‘C‐glycosides’

    Franz Baumberger;Andrea Vasella

  • Synthesis of a Glucose-Derived Tetrazole as a New β-Glucosidase Inhibitor. A New Synthesis of 1-Deoxynojirimycin

    Philipp Ermert;Andrea Vasella

  • Totalsynthese von Nojirimycin

    Andrea Vasella;Robert Voeffray

  • Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.

    Louise E Tailford;Wendy A Offen;Nicola L Smith;Claire Dumon

  • Aggregation of yeast cells: direct measurement of discrete lectin-carbohydrate interactions.

    Ahmed Touhami;Barbara Hoffmann;Andrea Vasella;Frédéric A. Denis

  • Probing specific lectin-carbohydrate interactions using atomic force microscopy imaging and force measurements

    Ahmed Touhami;Barbara Hoffmann;Andrea Vasella;Frédéric A. Denis

  • A Synthesis of 1D- and 1L-myo-Inositol 1,3,4,5,-Tetraphosphate

    Gisèle Baudin;Brigitte I. Glänzer;Kivalur S. Swaminathan;Andrea Vasella

  • SYNTHESIS OF A FULLERENE[60] CRYPTATE AND SYSTEMATIC LANGMUIR-BLODGETT AND THIN-FILM INVESTIGATIONS OF AMPHIPHILIC FULLERENE DERIVATIVES

    Ulrich Jonas;Francesca Cardullo;Pavel Belik;François Diederich

  • Nucleophilic Additions to N-Glycosylnitrones. Asymmetric Synthesis of α-Aminophosphonic Acids†‡

    Rolf Huber;Andreas Knierzinger;Jean‐Pierre Obrecht;Andrea Vasella

  • Glycosylidene Carbenes a new approach to glycoside synthesis. Part 1. Preparation of glycosylidene-derived diaziridines and diazirines†

    Karin Briner;Andrea Vasella

Frequent Co-Authors

Erik C. Böttger
Erik C. Böttger University of Zurich
David Crich
David Crich University of Georgia
Stephen G. Withers
Stephen G. Withers University of British Columbia
Roland Schauer
Roland Schauer Kiel University
Anthony Linden
Anthony Linden University of Zurich
Jochen Schacht
Jochen Schacht University of Michigan–Ann Arbor
Martin Meyer
Martin Meyer University of Zurich
Gideon J. Davies
Gideon J. Davies University of York
Andreas Billich
Andreas Billich Novartis (Switzerland)
Gennaro De Libero
Gennaro De Libero University Hospital of Basel

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