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Biology and Biochemistry

D-Index
60
Citations
17966
World Ranking
11752
National Ranking
211

Overview

Lluis Fajas is affiliated with the University of Lausanne in Switzerland and specializes in research primarily within the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work spans several subfields, including Molecular Biology, Cancer Research, Oncology, Immunology, and Epidemiology.

The research topics covered by Lluis Fajas focus on areas such as Cancer, Hypoxia, and Metabolism; Cancer-related Molecular Pathways; Metabolism, Diabetes, and Cancer; Pancreatic function and diabetes; Adipose Tissue and Metabolism; Mitochondrial Function and Pathology; and Epigenetics and DNA Methylation.

Among the notable recent publications are the following papers:

  • Cell cycle regulators in cancer cell metabolism, 2020, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  • Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity, 2020, Cellular and Molecular Immunology
  • The multifaceted role of cell cycle regulators in the coordination of growth and metabolism, 2020, FEBS Journal
  • The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer, 2021, Cancers
  • The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes, 2021, Nature Communications

Lluis Fajas has collaborated frequently with several co-authors, including Isabel C. López-Mejía, Katharina Huber, Dorian V. Ziegler, Pierre-Damien Denechaud, and Judit Castillo-Armengol. These collaborations have contributed to the development of research spread across multiple interdisciplinary domains.

Their work has been published in various scientific journals, with multiple publications appearing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, and iScience. Other journals include Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease and Cellular and Molecular Immunology.

Best Publications

  • A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.

    Samir S. Deeb;Lluis Fajas;Masami Nemoto;Jussi Pihlajamäki

  • The organization, promoter analysis, and expression of the human PPARgamma gene.

    Lluis Fajas;Didier Auboeuf;Eric Raspé;Kristina Schoonjans

  • Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients

    D Auboeuf;J Rieusset;L Fajas;P Vallier

  • Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism

    Aurélien Trompette;Eva S. Gollwitzer;Céline Pattaroni;Isabel C. Lopez-Mejia

  • Regulation of Peroxisome Proliferator-Activated Receptor γ Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism

    Lluis Fajas;Kristina Schoonjans;Laurent Gelman;Jae B. Kim

  • PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter

    Lluis Fajas;Jean-Charles Fruchart;Johan Auwerx

  • Persistent Organic Pollutant Exposure Leads to Insulin Resistance Syndrome

    Jérôme Ruzzin;Rasmus Petersen;Emmanuelle Meugnier;Lise Madsen

  • Transcriptional control of adipogenesis

    Lluis Fajas;Jean-Charles Fruchart;Johan Auwerx

  • E2Fs Regulate Adipocyte Differentiation

    Lluis Fajas;Rebecca L. Landsberg;Yolande Huss-Garcia;Claude Sardet

  • Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis.

    L Fajas;MB Debril;J Auwerx

  • Anandamide induced PPARγ transcriptional activation and 3T3-L1 preadipocyte differentiation

    Monsif Bouaboula;Sandrine Hilairet;Jean Marchand;Lluis Fajas

  • The pleiotropic functions of peroxisome proliferator-activated receptor γ

    Marie-Bernard Debril;Jean-Paul Renaud;Lluis Fajas;Johan Auwerx

  • The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation

    Lluis Fajas;Viviane Egler;Raphael Reiter;Jacob Hansen

  • E2F transcription factor-1 regulates oxidative metabolism

    Emilie Blanchet;Jean-Sébastien Annicotte;Sylviane Lagarrigue;Victor Aguilar

  • Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice

    Vanessa Fritz;Zohra Benfodda;Geneviève Rodier;Corinne Henriquet

  • p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively.

    Laurent Gelman;Gaochao Zhou;Lluis Fajas;Eric Raspé

  • A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans

    Aline Meirhaeghe;Lluis Fajas;Nicole Helbecque;Dominique Cottel

  • miR-143 Interferes with ERK5 Signaling, and Abrogates Prostate Cancer Progression in Mice

    Cyrielle Clapé;Vanessa Fritz;Corinne Henriquet;Florence Apparailly

  • Impact of the Peroxisome Proliferator Activated Receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus.

    A Meirhaeghe;L Fajas;N Helbecque;D Cottel

  • CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance

    Carine Chavey;Gwendal Lazennec;Sylviane Lagarrigue;Cyrielle Clapé

Frequent Co-Authors

Johan Auwerx
Johan Auwerx École Polytechnique Fédérale de Lausanne
Claude Sardet
Claude Sardet University of Montpellier
Jean-Charles Fruchart
Jean-Charles Fruchart Institut Pasteur
Vincent Cavaillès
Vincent Cavaillès Institute of Cancer Research of Montpellier
Kristina Schoonjans
Kristina Schoonjans École Polytechnique Fédérale de Lausanne
Pierre Dubus
Pierre Dubus University of Bordeaux
Robert Ballotti
Robert Ballotti Université Côte d'Azur
Samir S. Deeb
Samir S. Deeb University of Washington
Philippe Froguel
Philippe Froguel Imperial College London

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