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Molecular Biology

D-Index
54
Citations
13942
World Ranking
2311
National Ranking
86

Overview

Claude Sardet is affiliated with the University of Montpellier in France and has contributed extensively to the fields of biochemistry, genetics, and molecular biology as well as medicine. Their research primarily explores molecular biology with a focus on oncology and pulmonary and respiratory medicine.

The scientist has published numerous research papers, addressing a wide array of topics including DNA repair mechanisms, PARP inhibition in cancer therapy, RNA modifications and cancer, mitochondrial function and pathology, ATP synthase and ATPases research, genomics and chromatin dynamics, and advanced breast cancer therapies.

Recent publications by Claude Sardet include:

  • Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy? (2021) published in Cancers
  • CDK inhibition results in pharmacologic BRCAness increasing sensitivity to olaparib in BRCA1-WT and olaparib resistant in Triple Negative Breast Cancer (2024) published in Cancer Letters
  • RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation (2022) published in Scientific Reports
  • Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer (2022) published in International Journal of Molecular Sciences
  • E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development (2025) published in Nature Communications

The scientist frequently publishes in venues such as Geburtshilfe und Frauenheilkunde, Cancers, Cancer Letters, Scientific Reports, and the International Journal of Molecular Sciences.

Claude Sardet has collaborated often with colleagues including Geneviève Rodier, Imène Tabet, Charles Theillet, Lise Fenou, and William Jacot, reflecting a network of research partnerships supporting work in molecular biology and oncology.

The main topics of their research work encompass:

  • DNA Repair Mechanisms
  • PARP inhibition in cancer therapy
  • RNA modifications and cancer
  • Mitochondrial Function and Pathology
  • ATP Synthase and ATPases Research
  • Genomics and Chromatin Dynamics
  • Advanced Breast Cancer Therapies

Their expertise spans multiple subfields, with a significant focus on molecular biology and oncology, addressing challenges in cancer research and cellular mechanisms at the molecular level.

Best Publications

  • A Map of the Interactome Network of the Metazoan C. elegans

    Siming Li;Christopher M. Armstrong;Nicolas Bertin;Hui Ge

  • Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.

    Claude Sardet;Arlette Franchi;Jacques Pouysségur

  • Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

    P Lenormand;C Sardet;G Pagès;G L'Allemain

  • A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

    Jacques Pouyssegur;Claude Sardet;Arlette Franchi;Gilles L'Allemain

  • Post-activation Turn-off of NF-κB-dependent Transcription Is Regulated by Acetylation of p65

    Rosemary E. Kiernan;Vanessa Bres;Raymond W.M. Ng;Marie-Pierre Coudart

  • Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD.

    C Sardet;L Counillon;A Franchi;J Pouyssegur

  • Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

    Yan Geng;E. N. Eaton;M. Picon;J. M. Roberts

  • E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

    Claude Sardet;Marc Vidal;David Cobrinik;Yan Geng

  • The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing".

    S Wakabayashi;P Fafournoux;C Sardet;J Pouysségur

  • The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells

    Mathieu Tardat;Julien Brustel;Julien Brustel;Olivier Kirsh;Olivier Kirsh;Christine Lefevbre;Christine Lefevbre

  • E2Fs Regulate Adipocyte Differentiation

    Lluis Fajas;Rebecca L. Landsberg;Yolande Huss-Garcia;Claude Sardet

  • Negative regulation of transcription by the type II arginine methyltransferase PRMT5.

    Eric Fabbrizio;Selma El Messaoudi;Jolanta Polanowska;Conception Paul

  • The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin.

    Jean-Michel Bellanger;Catherine Astier;Claude Sardet;Yasutaka Ohta

  • Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice

    Vanessa Fritz;Zohra Benfodda;Geneviève Rodier;Corinne Henriquet

  • E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation

    Laurent Le Cam;Laëtitia K. Linares;Conception Paul;Eric Julien

  • Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism.

    S Grinstein;M Woodside;C Sardet;J Pouyssegur

  • Alpha-thrombin, epidermal growth factor, and okadaic acid activate the Na+/H+ exchanger, NHE-1, by phosphorylating a set of common sites.

    C Sardet;P Fafournoux;J Pouysségur

  • Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.

    Guus Hateboer;Albrecht Wobst;Birgit Otzen Petersen;Laurent Le Cam

  • Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene

    Selma El Messaoudi;Eric Fabbrizio;Carmen Rodriguez;Paul Chuchana

  • Cloning and expression of a cAMP-activated Na+/H+ exchanger: evidence that the cytoplasmic domain mediates hormonal regulation

    Franck Borgese;Claude Sardet;Marina Cappadoro;Jacques Pouyssegur

Frequent Co-Authors

Lluis Fajas
Lluis Fajas University of Lausanne
Jacques Pouysségur
Jacques Pouysségur Scientific Centre of Monaco
Charles Theillet
Charles Theillet University of Montpellier
Marc Vidal
Marc Vidal Harvard University
Benjamin C.Y. Wong
Benjamin C.Y. Wong University of Hong Kong
Ivan Hung
Ivan Hung University of Hong Kong
Pierre-Olivier Vidalain
Pierre-Olivier Vidalain Claude Bernard University Lyon 1
Pierre Dubus
Pierre Dubus University of Bordeaux
robert feil
robert feil Centre national de la recherche scientifique, CNRS
Bertrand Friguet
Bertrand Friguet Sorbonne University

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