Jacques Pouysségur

Research.com Recognitions

• 2025 - Research.com Biology and Biochemistry in France Leader Award
• 2023 - Research.com Biology and Biochemistry in France Leader Award
• 2022 - Research.com Biology and Biochemistry in France Leader Award
• 2001 - Member of Academia Europaea
• 1996 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for their contributions to the study of the regulation of cell division and differentiation.
• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)

Overview

Best Publications

• Tumor Cell Metabolism: Cancer's Achilles' Heel

  Guido Kroemer;Guido Kroemer;Guido Kroemer;Jacques Pouyssegur

  2691
  Citations

• Hypoxia signalling in cancer and approaches to enforce tumour regression

  Jacques Pouysségur;Frédéric Dayan;Nathalie M. Mazure

  2041
  Citations

• LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

  Almut Brand;Katrin Singer;Gudrun E. Koehl;Marlene Kolitzus

  1850
  Citations

• HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

  Edurne Berra;Emmanuel Benizri;Amandine Ginouvès;Véronique Volmat

  1672
  Citations

• Cyclin D1 Expression Is Regulated Positively by the p42/p44MAPK and Negatively by the p38/HOGMAPK Pathway

  Josée N. Lavoie;Gilles L'Allemain;Anne Brunet;Rolf Müller

  1599
  Citations

• Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

  Grégory Bellot;Raquel Garcia-Medina;Pierre Gounon;Johanna Chiche

  1561
  Citations

• The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

  S Meloche;J Pouysségur

  1327
  Citations

• Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

  Gille Pages;Philippe Lenormand;Gilles L'Allemain;Jean-Claude Chambard

  1277
  Citations

• p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

  Darren E. Richard;Edurne Berra;Emmanuel Gothié;Danièle Roux

  1032
  Citations

• Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.

  Claude Sardet;Arlette Franchi;Jacques Pouysségur

  960
  Citations

• Hypoxia and cancer

  M. Christiane Brahimi-Horn;Johanna Chiche;Jacques Pouysségur

  907
  Citations

• Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity

  Eoin P. Cummins;Edurne Berra;Katrina M. Comerford;Amandine Ginouves

  903
  Citations

• ERK implication in cell cycle regulation.

  Jean-Claude Chambard;Renaud Lefloch;Jacques Pouysségur;Philippe Lenormand

  900
  Citations

• Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

  Gilles Pagès;Sandrine Guérin;Dominique Grall;Frédéric Bonino

  887
  Citations

• Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

  P Lenormand;C Sardet;G Pagès;G L'Allemain

  848
  Citations

• Nonhypoxic Pathway Mediates the Induction of Hypoxia-inducible Factor 1α in Vascular Smooth Muscle Cells *

  Darren E. Richard;Edurne Berra;Jacques Pouysségur

  842
  Citations

• JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

  Damien Gerald;Edurne Berra;Yves M. Frapart;Denise A. Chan

  825
  Citations

• Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

  Johanna Chiche;Karine Ilc;Julie Laferrière;Eric Trottier

  803
  Citations

• Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

  Johanna Chiche;M Christiane Brahimi-Horn;Jacques Pouysségur

  782
  Citations

• Nuclear translocation of p42/p44 mitogen‐activated protein kinase is required for growth factor‐induced gene expression and cell cycle entry

  Anne Brunet;Danièle Roux;Philippe Lenormand;Stephen Dowd

  746
  Citations