World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
9144
World Ranking
16734
National Ranking
6910

Overview

C. Chris Yun is affiliated with Emory University in the United States and has contributed to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans multiple subfields including Molecular Biology, Physiology, Surgery, Immunology, and Oncology. The scientist's research topics frequently involve Sphingolipid Metabolism and Signaling, PI3K/AKT/mTOR signaling in cancer, Pancreatic function and diabetes, Metabolism, Diabetes, and Cancer, Diet and metabolism studies, and Phagocytosis and Immune Regulation.

Their recent publications demonstrate a focus on cellular and physiological mechanisms related to gastrointestinal and neurological health. Key recent papers include:

  • Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial (2023) published in Nature Medicine
  • Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5 (2021) published in Cellular and Molecular Gastroenterology and Hepatology
  • Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA5-Dependent Signaling (2022) published in Cellular and Molecular Gastroenterology and Hepatology
  • Metformin Inhibits Na+/H+ Exchanger NHE3 Resulting in Intestinal Water Loss (2022) published in Frontiers in Physiology
  • Nedd4-2-dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli (2021) published in Cellular and Molecular Gastroenterology and Hepatology

The scientist has published multiple articles in key venues such as:

  • Cellular and Molecular Gastroenterology and Hepatology
  • Nature Medicine
  • American Journal of Physiology-Gastrointestinal and Liver Physiology
  • Gastroenterology
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature

Collaboration has been a significant part of Yun's research, with frequent co-authors including Yiran Han, Peijian He, Laurence Mignon, Catherine J. Mummery, and Holly Kordasiewicz. These collaborations highlight interdisciplinary teamwork in areas ranging from physiology to molecular signaling pathways.

Best Publications

  • cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.

    C. H Chris Yun;Soohyuk Oh;Mirza Zizak;Deborah Steplock;Deborah Steplock

  • NHE2 and NHE3 are human and rabbit intestinal brush-border proteins.

    W. A. Hoogerwerf;S. C. Tsao;O. Devuyst;S. A. Levine

  • Na + /H + exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling

    Matthew J. Mahon;Mark Donowitz;C. Chris Yun;Gino V. Segre

  • NHE3 KINASE A REGULATORY PROTEIN E3KARP BINDS THE EPITHELIAL BRUSH BORDER NA+/H+ EXCHANGER NHE3 AND THE CYTOSKELETAL PROTEIN EZRIN

    C.-H. Chris Yun;Georg Lamprecht;David V. Forster;Agnieszka Sidor

  • Mammalian Na+/H+ exchanger gene family: structure and function studies

    C. H C Yun;Chung Ming Tse;S. K. Nath;S. A. Levine

  • Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.

    Anurag Kumar Singh;Brigitte Riederer;Anja Krabbenhöft;Brigitte Rausch

  • E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells.

    Fei Sun;Martin J. Hug;Christopher M. Lewarchik;C.-H. Chris Yun

  • Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2).

    Chung-Ming Tse;Susan A. Levine;C. H. Chris Yun;Marshall H. Montrose

  • The Role of NHERF and E3KARP in the cAMP-mediated Inhibition of NHE3

    Georg Lamprecht;Edward J. Weinman;C.-H. Chris Yun

  • Glucocorticoid Activation of Na+/H+Exchanger Isoform 3 Revisited THE ROLES OF SGK1 AND NHERF2

    C. Chris Yun;Yueping Chen;Florian Lang

  • Structure/function studies of the epithelial isoforms of the mammalian Na+/H+ exchanger gene family

    Ming Tse;Sue Levine;Chris Yun;Steve Brant

  • Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3

    S. R. Brant;C. H. Chris Yun;M. Donowitz;C.-M. Tse

  • The Absence of LPA2 Attenuates Tumor Formation in an Experimental Model of Colitis-Associated Cancer

    Songbai Lin;Dongsheng Wang;Smita Iyer;Amr M. Ghaleb

  • Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): Resistance to amiloride and inhibition by protein kinase C

    Chung Ming Tse;Susan A. Levine;C. H.Chris Yun;Steven R. Brant

  • The Serum and Glucocorticoid-Inducible Kinase SGK1 and the Na+/H+ Exchange Regulating Factor NHERF2 Synergize to Stimulate the Renal Outer Medullary K+ Channel ROMK1

    C. Chris Yun;Monica Palmada;Hamdy M. Embark;Olga Fedorenko

  • Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactions.

    Laura Fouassier;C. Chris Yun;J. Gregory Fitz;R. Brian Doctor

  • The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange.

    Georg Lamprecht;Andreas Heil;Susannah Baisch;Elena Lin-Wu

  • Protein Kinase Cε-dependent Regulation of Cystic Fibrosis Transmembrane Regulator Involves Binding to a Receptor for Activated C Kinase (RACK1) and RACK1 Binding to Na+/H+ Exchange Regulatory Factor

    Carole M. Liedtke;C. H. Chris Yun;Nicole Kyle;Dandan Wang

  • Glucocorticoid stimulation of ileal Na+ absorptive cell brush border Na+/H+ exchange and association with an increase in message for NHE-3, an epithelial Na+/H+ exchanger isoform

    C. H Chris Yun;Sarada Gurubhagavatula;Susan A. Levine;Jami L M Montgomery

  • Development of a unique small molecule modulator of CXCR4.

    Zhongxing Liang;Weiqiang Zhan;Aizhi Zhu;Younghyoun Yoon

Frequent Co-Authors

Mark Donowitz
Mark Donowitz Johns Hopkins University School of Medicine
Edward J. Weinman
Edward J. Weinman University of Maryland, Baltimore
Florian Lang
Florian Lang University of Tübingen
Chung Ming Tse
Chung Ming Tse Johns Hopkins University School of Medicine
Randy A. Hall
Randy A. Hall Emory University
Steven R. Brant
Steven R. Brant Rutgers, The State University of New Jersey
Jerold Chun
Jerold Chun Sanford Burnham Prebys Medical Discovery Institute
Hugo R. de Jonge
Hugo R. de Jonge Erasmus University Rotterdam
Vincent W. Yang
Vincent W. Yang Stony Brook University
Yoland Smith
Yoland Smith Emory University

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