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Biology and Biochemistry

D-Index
63
Citations
13160
World Ranking
10287
National Ranking
267

Overview

Hugo R. de Jonge is affiliated with Erasmus University Rotterdam in the Netherlands and has contributed extensively to the field of Medicine, with a focus on pulmonary and respiratory medicine, surgery, genetics, molecular biology, and hepatology. Their research spans multiple subfields, addressing complex medical issues with a multidisciplinary approach.

The scientist's work has been published in several notable journals, including the Journal of Cystic Fibrosis, where they have four publications. Other frequent publication venues include Scientific Reports and Biotechnology and Bioengineering, each featuring two of their research articles, as well as Food & Function and Antiviral Research with one publication each.

Hugo R. de Jonge's main topics of research revolve around:

  • Cystic Fibrosis Research Advances
  • Neonatal Respiratory Health Research
  • Pediatric Hepatobiliary Diseases and Treatments
  • Liver physiology and pathology
  • Pancreatitis Pathology and Treatment
  • Digestive system and related health
  • Gut microbiota and health

Their recent published papers include:

  • Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease, 2020, Scientific Reports
  • Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet, 2021, Food & Function
  • Scaffolds obtained from decellularized human extrahepatic bile ducts support organoids to establish functional biliary tissue in a dish, 2020, Biotechnology and Bioengineering
  • Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway, 2020, Antiviral Research
  • Bicarbonate Transport in Cystic Fibrosis and Pancreatitis, 2021, Cells

Frequent co-authors collaborating with Hugo R. de Jonge include Marcel J. C. Bijvelds, Monique M.A. Verstegen, Luc J. W. van der Laan, Floris J.M. Roos, and Henk P. Roest. These collaborations highlight connections with researchers focusing on similar biomedical and clinical topics.

Best Publications

  • A functional CFTR assay using primary cystic fibrosis intestinal organoids

    Johanna F Dekkers;Caroline L Wiegerinck;Hugo R de Jonge;Inez Bronsveld

  • Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

    Johanna F. Dekkers;Gitte Berkers;Evelien Kruisselbrink;Annelotte Vonk

  • Distinct and specific functions of cGMP-dependent protein kinases

    Suzanne M. Lohmann;Arie B. Vaandrager;Albert Smolenski;Ulrich Walter

  • Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System Insights From Genetically Modified Mice

    Robert Feil;Suzanne M. Lohmann;Hugo de Jonge;Ulrich Walter

  • Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.

    Anurag Kumar Singh;Brigitte Riederer;Anja Krabbenhöft;Brigitte Rausch

  • Mouse models of cystic fibrosis: Phenotypic analysis and research applications

    Martina Wilke;Ruvalic M. Buijs-Offerman;Jamil Aarbiou;William H. Colledge

  • Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology

    Nicholas C. Zachos;Olga Kovbasnjuk;Jennifer Foulke-Abel;Julie In

  • Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

    Gitte Berkers;Peter van Mourik;Annelotte M. Vonk;Evelien Kruisselbrink

  • Chloride conductance and genetic background modulate the cystic fibrosis phenotype of ΔF508 homozygous twins and siblings

    Inez Bronsveld;Frauke Mekus;Jan Bijman;Manfred Ballmann

  • Membrane Targeting of cGMP-Dependent Protein Kinase is Required for Cystic Fibrosis Transmembrane Conductance Regulator Cl - Channel Activation

    Arie. B. Vaandrager;Albert Smolenski;Ben C. Tilly;Adriaan B. Houtsmuller

  • Modeling rotavirus infection and antiviral therapy using primary intestinal organoids.

    Yuebang Yin;Marcel Bijvelds;Wen Dang;Lei Xu

  • Isotype-specific Activation of Cystic Fibrosis Transmembrane Conductance Regulator-Chloride Channels by cGMP-dependent Protein Kinase II

    Pim J. French;Jan Bijman;Marcel Edixhoven;Arie B. Vaandrager

  • Folding of CFTR Is Predominantly Cotranslational

    Bertrand Kleizen;Thijs van Vlijmen;Hugo R. de Jonge;Ineke Braakman

  • Studies in Zebrafish Reveal Unusual Cellular Expression Patterns of Gonadotropin Receptor Messenger Ribonucleic Acids in the Testis and Unexpected Functional Differentiation of the Gonadotropins

    Ángel García-López;Hugo de Jonge;Rafael H. Nóbrega;Paul P. de Waal

  • IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo.

    Linda B. C. Bralten;Nanne K. Kloosterhof;Rutger Balvers;Andrea Sacchetti

  • Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol.

    Koen van de Wetering;Alexander Burkon;Wouter Feddema;Alice Bot

  • Animal models of cystic fibrosis

    Bob J. Scholte;Donald J. Davidson;Martina Wilke;Hugo R. de Jonge

  • Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colon

    Arie B. Vaandrager;Alice G.M. Bot;Peter Ruth;Alexander Pfeifer

  • Characterization of a proton-driven carrier for sialic acid in the lysosomal membrane. Evidence for a group-specific transport system for acidic monosaccharides.

    G. M. S. Mancini;H. R. De Jonge;H. Galjaard;F. W. Verheijen

  • Guanylyl cyclase C is an N-linked glycoprotein receptor that accounts for multiple heat-stable enterotoxin-binding proteins in the intestine.

    A B Vaandrager;S Schulz;H R De Jonge;D L Garbers

Frequent Co-Authors

Mark Donowitz
Mark Donowitz Johns Hopkins University School of Medicine
Suzanne M. Lohmann
Suzanne M. Lohmann University of Würzburg
Edward J. Weinman
Edward J. Weinman University of Maryland, Baltimore
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Luc J. W. van der Laan
Luc J. W. van der Laan Erasmus University Rotterdam
Franz Hofmann
Franz Hofmann Technical University of Munich
C. Chris Yun
C. Chris Yun Emory University
Burkhard Tümmler
Burkhard Tümmler Hannover Medical School
Maikel P. Peppelenbosch
Maikel P. Peppelenbosch Erasmus University Rotterdam
Mary K. Estes
Mary K. Estes Baylor College of Medicine

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