Christine E. Bear

Overview

Best Publications

• Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

  Christine E. Bear;Canhui Li;Norbert Kartner;Robert J. Bridges

  1167
  Citations

• Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

  Norbert Kartner;John W. Hanrahan;Tim J. Jensen;A. Leonard Naismith

  604
  Citations

• Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor

  Richard Rozmahel;Michael Wilschanski;Angabin Matin;Suzanne Plyte

  548
  Citations

• Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein.

  Amy P Wong;Christine E Bear;Stephanie Chin;Peter Pasceri

  443
  Citations

• ATPase Activity of the Cystic Fibrosis Transmembrane Conductance Regulator

  Canhui Li;Mohabir Ramjeesingh;Wei Wang;Elizabeth Garami

  384
  Citations

• Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.

  Paul D.W. Eckford;Canhui Li;Mohabir Ramjeesingh;Christine E. Bear

  375
  Citations

• The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.

  Gergely L. Lukacs;Xiu Bao Chang;Christine Bear;Norbert Kartner

  362
  Citations

• Directed differentiation of cholangiocytes from human pluripotent stem cells

  Mina Ogawa;Shinichiro Ogawa;Christine E Bear;Saumel Ahmadi

  284
  Citations

• Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.

  C E Bear;F Duguay;A L Naismith;N Kartner

  268
  Citations

• The cystic fibrosis mutation (delta F508) does not influence the chloride channel activity of CFTR.

  Canhui Li;Mohabir Ramjeesingh;Evangelica Reyes;Tim Jensen

  265
  Citations

• CFTR directly mediates nucleotide-regulated glutathione flux

  Ilana Kogan;Mohabir Ramjeesingh;Canhui Li;Jackie F. Kidd

  217
  Citations

• LUNG DISEASE IN MICE WITH CYSTIC FIBROSIS

  G Kent;R Iles;C E Bear;L J Huan

  209
  Citations

• Novel method for evaluation of the oligomeric structure of membrane proteins.

  Mohabir Ramjeesingh;Ling-Jun Huan;Elizabeth Garami;Christine E. Bear

  200
  Citations

• Expression of the chloride channel ClC-2 in the murine small intestine epithelium.

  Katalin Gyömörey;Herman Yeger;Cameron Ackerley;Elizabeth Garami

  162
  Citations

• Purified cystic fibrosis transmembrane conductance regulator (CFTR) does not function as an ATP channel.

  Canhui Li;Mohabir Ramjeesingh;Christine E. Bear

  162
  Citations

• Walker mutations reveal loose relationship between catalytic and channel-gating activities of purified CFTR (cystic fibrosis transmembrane conductance regulator)

  Mohabir Ramjeesingh;Canhui Li;Elizabeth Garami;Ling-Jun Huan

  159
  Citations

• Cystic fibrosis transmembrane conductance regulator in human muscle: Dysfunction causes abnormal metabolic recovery in exercise

  Anne-Marie Lamhonwah;Christine E Bear;Ling Jun Huan;Patrick Kim Chiaw

  133
  Citations

• The chloride channel ClC-4 contributes to endosomal acidification and trafficking.

  Raha Mohammad-Panah;Rene Harrison;Sonja Dhani;Cameron Ackerley

  132
  Citations

• Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator.

  Onofrio Laselva;Claire Bartlett;Tarini N.A. Gunawardena;Hong Ouyang

  123
  Citations

• The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor

  Steven D. Broadbent;Steven D. Broadbent;Mohabir Ramjeesingh;Christine E. Bear;Barry E. Argent

  17
  Citations