What is she best known for?
The fields of study she is best known for:
Her primary areas of investigation include Cystic fibrosis transmembrane conductance regulator, Cell biology, Chloride channel, Cystic fibrosis and Biochemistry.
Her Cystic fibrosis transmembrane conductance regulator study combines topics from a wide range of disciplines, such as Secretion, Mutant protein and Molecular biology.
Her biological study spans a wide range of topics, including Biophysics, Endoplasmic reticulum and Chinese hamster ovary cell.
Her work deals with themes such as Cell culture, Gene expression, Induced pluripotent stem cell, Directed differentiation and Flux, which intersect with Cell biology.
Her Chloride channel research incorporates themes from Congenic, Disease, Ion channel, Endomembrane system and Endosome.
Her Cystic fibrosis research is multidisciplinary, relying on both Mutation, Transfection, Function and Phosphorylation.
Her most cited work include:
- Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR) (834 citations)
- Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance (446 citations)
- Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor (354 citations)
What are the main themes of her work throughout her whole career to date?
Her primary scientific interests are in Cystic fibrosis transmembrane conductance regulator, Cell biology, Cystic fibrosis, Biochemistry and Chloride channel.
Christine E. Bear does research in Cystic fibrosis transmembrane conductance regulator, focusing on Chloride channel activity specifically.
Her Cell biology course of study focuses on Transporter and Function.
Her studies in Cystic fibrosis integrate themes in fields like Mutation and Immunology, Potentiator.
As part of the same scientific family, Christine E. Bear usually focuses on Biochemistry, concentrating on Biophysics and intersecting with Intracellular, Membrane, Lipid bilayer and Adenine nucleotide.
Her work investigates the relationship between Chloride channel and topics such as Molecular biology that intersect with problems in Transmembrane protein.
She most often published in these fields:
- Cystic fibrosis transmembrane conductance regulator (50.29%)
- Cell biology (45.66%)
- Cystic fibrosis (43.35%)
What were the highlights of her more recent work (between 2016-2021)?
- Cystic fibrosis (43.35%)
- Cystic fibrosis transmembrane conductance regulator (50.29%)
- Cell biology (45.66%)
In recent papers she was focusing on the following fields of study:
The scientist’s investigation covers issues in Cystic fibrosis, Cystic fibrosis transmembrane conductance regulator, Cell biology, Mutant and Mutation.
The study incorporates disciplines such as Cancer research, CRISPR, Bioinformatics, Induced pluripotent stem cell and Drug in addition to Cystic fibrosis.
Her Cystic fibrosis transmembrane conductance regulator study incorporates themes from HEK 293 cells, Chloride channel, Molecular biology and Phosphorylation.
Her Cell biology study combines topics in areas such as Cell, Cell type, Cell culture, Mutant protein and Anion channel activity.
Her Mutant research includes elements of Nonsense mutation, Potentiator and Transmembrane protein.
Her Mutation research includes themes of In silico, Transfection, Small molecule and Drug discovery.
Between 2016 and 2021, her most popular works were:
- Orkambi® and amplifier co‐therapy improves function from a rare CFTR mutation in gene‐edited cells and patient tissue (57 citations)
- Orkambi® and amplifier co‐therapy improves function from a rare CFTR mutation in gene‐edited cells and patient tissue (57 citations)
- Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia. (33 citations)
In her most recent research, the most cited papers focused on:
Her main research concerns Cystic fibrosis, Cystic fibrosis transmembrane conductance regulator, Cell biology, Mutant and Mutation.
Her Cystic fibrosis research is multidisciplinary, incorporating elements of Cancer research, Lung and Microbiology.
Her biological study spans a wide range of topics, including HEK 293 cells and Mutant protein.
Her study in the field of Progenitor cell is also linked to topics like Population.
Her work deals with themes such as Protein kinase A, Phosphorylation, Calcium signaling, Chloride channel and Calmodulin, which intersect with Mutant.
Her Mutation research is multidisciplinary, relying on both In silico, Small molecule and Bioinformatics.
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