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Bertrand Friguet

Bertrand Friguet

D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
19327
World Ranking
5341
National Ranking
151

Overview

Bertrand Friguet is affiliated with Sorbonne University in France and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research primarily addresses molecular mechanisms underlying aging, cellular senescence, and redox biology. The scientist's work spans subfields including molecular biology, immunology, dermatology, biochemistry, and cancer research.

Friguet's main research topics encompass:

  • Redox biology and oxidative stress
  • Skin protection and aging
  • Mitochondrial function and pathology
  • Genetics, aging, and longevity in model organisms
  • Cancer, hypoxia, and metabolism
  • Telomeres, telomerase, and senescence
  • Neutrophil, myeloperoxidase, and oxidative mechanisms

The scientist's recent papers include:

  • Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework, 2020, published in Mechanisms of Ageing and Development
  • A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism, 2024, published in Nature Metabolism
  • Effects of cellular senescence on metabolic pathways in non-immune and immune cells, 2020, published in Mechanisms of Ageing and Development
  • Glyoxal Induces Senescence in Human Keratinocytes through Oxidative Stress and Activation of the Protein Kinase B/FOXO3a/p27KIP1 Pathway, 2021, published in Journal of Investigative Dermatology
  • Thioredoxin-1 and its mimetic peptide improve systolic cardiac function and remodeling after myocardial infarction, 2023, published in The FASEB Journal

Frequent publication venues where Friguet has contributed include:

  • Free Radical Biology and Medicine (9 publications)
  • Archives of Cardiovascular Diseases Supplements (4 publications)
  • Mechanisms of Ageing and Development (2 publications)
  • Journal of Investigative Dermatology (2 publications)
  • Nature Metabolism (1 publication)

Friguet collaborates regularly with several researchers, notably:

  • Dominique Couchie
  • Mustapha Rouis
  • Tania Medali
  • Aurore L'honoré
  • Nathalie Mougenot

The scientist's body of work reflects a multidisciplinary approach linking biochemical pathways and molecular mechanisms to physiological and pathological processes related to aging and cellular senescence. The integrated study of redox biology, lipid metabolism, and mitochondrial function is evident across the publications and coauthorship networks.

Best Publications

  • Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay.

    Bertrand Friguet;Alain F. Chaffotte;Lisa Djavadi-Ohaniance;Michel E. Goldberg

  • NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

    Amna Abderrazak;Tatiana Syrovets;Dominique Couchie;Khadija El Hadri

  • Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

    Viviana I. Pérez;Rochelle Buffenstein;Venkata Masamsetti;Shanique Leonard

  • Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

    Niki Chondrogianni;Fiona L.L. Stratford;Ioannis P. Trougakos;Bertrand Friguet

  • Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease.

    Bertrand Friguet;Earl R. Stadtman;Luke I. Szweda

  • Oxidative Modification and Inactivation of the Proteasome during Coronary Occlusion/Reperfusion

    Anne Laure Bulteau;Kathleen C. Lundberg;Kenneth M. Humphries;Hesham A. Sadek

  • Impairment of proteasome structure and function in aging

    Géraldine Carrard;Anne-Laure Bulteau;Isabelle Petropoulos;Bertrand Friguet

  • Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

    Silvia Carnio;Francesca LoVerso;Martin Andres Baraibar;Emanuela Longa

  • Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein

    Bertrand Friguet;Luke I Szweda

  • Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease.

    Günter U. Höglinger;Géraldine Carrard;Patrick P. Michel;Fadia Medja

  • A convenient enzyme-linked immunosorbent assay for testing whether monoclonal antibodies recognize the same antigenic site. Application to hybridomas specific for the beta 2-subunit of Escherichia coli tryptophan synthase.

    Bertrand Friguet;Lisa Djavadi-Ohaniance;Jacqueline Pages;Alain Bussard

  • Age-dependent declines in proteasome activity in the heart.

    Anne-Laure Bulteau;Luke I. Szweda;Bertrand Friguet

  • Some monoclonal antibodies raised with a native protein bind preferentially to the denatured antigen.

    Bertrand Friguet;Lisa Djavadi-Ohaniance;Michel E. Goldberg

  • Oxidized protein degradation and repair in ageing and oxidative stress.

    Bertrand Friguet

  • Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-β1 signaling pathway

    Florence Debacq-Chainiaux;Céline Borlon;Thierry Pascal;Véronique Royer

  • Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90.

    Mariangela Conconi;Luke I. Szweda;Rodney L. Levine;Earl R. Stadtman

  • Protein damage, repair and proteolysis.

    Niki Chondrogianni;Isabelle Petropoulos;Stefanie Grimm;Konstantina Georgila

  • MARK-AGE biomarkers of ageing

    Alexander Bürkle;María Moreno-Villanueva;Jürgen Bernhard;María Blasco

  • Fibroblast cultures from healthy centenarians have an active proteasome.

    N Chondrogianni;I Petropoulos;C Franceschi;B Friguet

  • Age-related alterations of proteasome structure and function in aging epidermis.

    A.-L Bulteau;I Petropoulos;B Friguet

Frequent Co-Authors

Michel E. Goldberg
Michel E. Goldberg Université Paris Cité
Efstathios S. Gonos
Efstathios S. Gonos National Hellenic Research Foundation
Zhenlin Li
Zhenlin Li Université Paris Cité
Claudio Franceschi
Claudio Franceschi University of Bologna
Luke I. Szweda
Luke I. Szweda The University of Texas Southwestern Medical Center
Earl R. Stadtman
Earl R. Stadtman National Institutes of Health
Tamas Fulop
Tamas Fulop Université de Sherbrooke
Etienne C. Hirsch
Etienne C. Hirsch Sorbonne University
Vadim N. Gladyshev
Vadim N. Gladyshev Brigham and Women's Hospital
Tilman Grune
Tilman Grune University of Potsdam

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