World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
66
Citations
14634
World Ranking
7330
National Ranking
2170

Biology and Biochemistry

D-Index
75
Citations
18788
World Ranking
5355
National Ranking
2539

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Luke I. Szweda is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions to Medicine.

The scientist has a strong focus on several subfields, including Molecular Biology, Cardiology and Cardiovascular Medicine, Physiology, Biochemistry, and Surgery. Their scholarly output covers a range of topics, with notable emphasis on Mitochondrial Function and Pathology, Cardiovascular Function and Risk Factors, Congenital Heart Defects Research, Adipose Tissue and Metabolism, Diet and Metabolism Studies, Metabolism, Diabetes, and Cancer, as well as Pancreatic Function and Diabetes.

Their recent published papers include:

  • "Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression" (2020, Nature Metabolism)
  • "NAD + Repletion Reverses Heart Failure With Preserved Ejection Fraction" (2021, Circulation Research)
  • "Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome to Regulate Cardiac Function" (2020, Circulation)
  • "PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart" (2021, Circulation)
  • "Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue" (2021, Cell stem cell)

Luke I. Szweda frequently collaborates with several researchers. Frequent coauthors include Abdallah Elnwasany, Pamela A. Szweda, Michael Kinter, Joseph A. Hill, and Hesham A. Sadek.

Their work commonly appears in prominent scientific journals such as Circulation Research, Circulation, Proceedings of the National Academy of Sciences, bioRxiv (Cold Spring Harbor Laboratory), and Nature Metabolism.

In recognition of contributions to science, Luke I. Szweda was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2013.

Best Publications

  • The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response.

    Bao N. Puente;Wataru Kimura;Shalini A. Muralidhar;Jesung Moon

  • Hypoxia induces heart regeneration in adult mice

    Yuji Nakada;Diana C. Canseco;Suwannee Thet;Salim Abdisalaam

  • The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Aβ1–42

    Christopher M. Lauderback;Janna M. Hackett;Feng F. Huang;Jeffrey N. Keller

  • Modulation of Mitochondrial Function by Hydrogen Peroxide

    Amy C. Nulton-Persson;Luke I. Szweda

  • Frataxin Acts as an Iron Chaperone Protein to Modulate Mitochondrial Aconitase Activity

    Anne Laure Bulteau;Heather A. O'Neill;Mary Claire Kennedy;Masao Ikeda-Saito

  • Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation

    Mariana G. Rosca;Tiberiu G. Mustata;Michael T. Kinter;Aylin M. Ozdemir

  • Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal.

    Kenneth M. Humphries;Luke I. Szweda

  • Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes

    Koji Uchida;Luke I. Szweda;Ho-Zoon Chae;Earl R. Stadtman

  • Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease.

    Bertrand Friguet;Earl R. Stadtman;Luke I. Szweda

  • Oxidative Modification and Inactivation of the Proteasome during Coronary Occlusion/Reperfusion

    Anne Laure Bulteau;Kathleen C. Lundberg;Kenneth M. Humphries;Hesham A. Sadek

  • Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine.

    L. I. Szweda;K. Uchida;Lin Tsai;E. R. Stadtman

  • Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

    Kentaro Hirose;Alexander Y. Payumo;Stephen Cutie;Alison Hoang

  • Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein

    Bertrand Friguet;Luke I Szweda

  • Cardiac reperfusion injury: Aging, lipid peroxidation, and mitochondrial dysfunction

    David T. Lucas;Luke I. Szweda

  • Age-dependent declines in proteasome activity in the heart.

    Anne-Laure Bulteau;Luke I. Szweda;Bertrand Friguet

  • Redox-Dependent Modulation of Aconitase Activity in Intact Mitochondria

    Anne Laure Bulteau;Masao Ikeda-Saito;Luke I. Szweda

  • Inhibition of NADH-Linked Mitochondrial Respiration by 4-Hydroxy-2-nonenal†

    Kenneth M. Humphries;Young Yoo;Luke I. Szweda

  • Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90.

    Mariangela Conconi;Luke I. Szweda;Rodney L. Levine;Earl R. Stadtman

  • Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle

    Theodor A. Zainal;Terry D. Oberley;David B. Allison;Luke I. Szweda

  • Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis

    Heike L. Rittner;Verena Hafner;Piotr A. Klimiuk;Luke I. Szweda

  • Erratum: The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response (Cell (2014) 157 (741-743))

    Bao N. Puente;Wataru Kimura;Shalini A. Muralidhar;Jesung Moon

Frequent Co-Authors

Michael Kinter
Michael Kinter Oklahoma Medical Research Foundation
Bertrand Friguet
Bertrand Friguet Sorbonne University
Cornelia M. Weyand
Cornelia M. Weyand Stanford University
Jörg J. Goronzy
Jörg J. Goronzy Stanford University
Masao Ikeda-Saito
Masao Ikeda-Saito Tohoku University
William R. Markesbery
William R. Markesbery University of Kentucky
Andrij Holian
Andrij Holian University of Montana
Vincent M. Monnier
Vincent M. Monnier Case Western Reserve University
Daria Mochly-Rosen
Daria Mochly-Rosen Stanford University
Terry D. Oberley
Terry D. Oberley University of Wisconsin–Madison

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing studies in Biology and Biochemistry opens doors to a variety of rewarding careers, especially in health information and medical coding. With the growth of healthcare services, roles like medical coder and health information manager are increasingly in demand and offer strong job security.

Obtaining a certification, such as cpc certification, allows professionals to stand out and often leads to higher earning potential. In fact, if you’re curious about salaries and responsibilities, check out this resource on what is medical coding salary for detailed information.

Many students wonder: is medical billing and coding in demand? The answer is yes, especially as healthcare data becomes central to patient care and administration. If you’re considering flexible study options, there are numerous health information management online programs that offer affordable pathways to these quickly growing fields.

By mixing your knowledge of biology with skills in data and coding, you can access a variety of professional opportunities in today’s healthcare landscape.

Best Scientists Citing Luke I. Szweda

Trending Scientists