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Biology and Biochemistry

D-Index
58
Citations
11690
World Ranking
13211
National Ranking
27

Overview

Efstathios S. Gonos is affiliated with the National Hellenic Research Foundation in Greece. Their research spans multiple fields, primarily within medicine and biochemistry, genetics, and molecular biology. The scientist's work focuses extensively on molecular biology, physiology, and aging, with additional attention to nutrition, dietetics, and cardiovascular medicine.

The main topics covered by their research include:

  • Genetics, Aging, and Longevity in Model Organisms
  • Nutritional Studies and Diet
  • Telomeres, Telomerase, and Senescence
  • Ubiquitin and proteasome pathways
  • Antioxidant Activity and Oxidative Stress
  • Animal Virus Infections Studies
  • Cytomegalovirus and herpesvirus research

Frequently publishing in several journals, Efstathios S. Gonos has contributed notably to:

  • Mechanisms of Ageing and Development
  • The Journals of Gerontology Series A
  • IUBMB Life
  • GeroScience
  • Antioxidants

Their recent papers demonstrate research activity on varied aspects of aging and biological health markers. Notable publications include:

  • Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework (2020, Mechanisms of Ageing and Development)
  • Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains (2021, Scientific Reports)
  • The conundrum of human immune system "senescence" (2020, Mechanisms of Ageing and Development)
  • Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia (2021, Mechanisms of Ageing and Development)
  • Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study (2021, Frontiers in Microbiology)

Collaboration is a significant aspect of their scientific work, with frequent co-authors including:

  • Claudio Franceschi
  • Ewa Sikora
  • Martijn E.T. Dollé
  • Tilman Grune
  • Miriam Capri

The interconnected nature of their research within aging biology, molecular pathways, and immunology situates Efstathios S. Gonos as an active contributor to contemporary scientific discussions surrounding longevity and cellular mechanisms. Their multidisciplinary involvement spans from fundamental molecular biology to applied nutritional and gerontological studies.

Best Publications

  • Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response.

    Diana Jurk;Chunfang Wang;Satomi Miwa;Mandy Maddick

  • Clusterin/apolipoprotein J in human aging and cancer.

    Ioannis P Trougakos;Efstathios S Gonos

  • Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast

    Patrick Dumont;Maggi Burton;Qin M. Chen;Efstathios S. Gonos

  • Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

    Niki Chondrogianni;Fiona L.L. Stratford;Ioannis P. Trougakos;Bertrand Friguet

  • Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

    Ana Luisa Cardoso;Adelaide Fernandes;Juan Antonio Aguilar-Pimentel;Martin Hrabe de Angelis

  • Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress.

    Ioannis P. Trougakos;Alan So;Burkhard Jansen;Martin E. Gleave

  • Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts.

    Suzanne Kapeta;Niki Chondrogianni;Efstathios S. Gonos

  • Protein damage, repair and proteolysis.

    Niki Chondrogianni;Isabelle Petropoulos;Stefanie Grimm;Konstantina Georgila

  • MARK-AGE biomarkers of ageing

    Alexander Bürkle;María Moreno-Villanueva;Jürgen Bernhard;María Blasco

  • Fibroblast cultures from healthy centenarians have an active proteasome.

    N Chondrogianni;I Petropoulos;C Franceschi;B Friguet

  • Overexpression of Proteasome β5 Assembled Subunit Increases the Amount of Proteasome and Confers Ameliorated Response to Oxidative Stress and Higher Survival Rates

    Niki Chondrogianni;Christos Tzavelas;Alexander J. Pemberton;Ioannis P. Nezis

  • Anti-ageing and rejuvenating effects of quercetin

    Niki Chondrogianni;Suzanne Kapeta;Ioanna Chinou;Katerina Vassilatou

  • Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

    Marian Beekman;Hélène Blanché;Markus Perola;Anti Hervonen

  • Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases

    Ioannis P. Trougakos;Efstathios S. Gonos

  • Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction.

    Ioannis P Trougakos;Maria Poulakou;Marios Stathatos;Anastasia Chalikia

  • The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts.

    Magda Katsiki;Niki Chondrogianni;Ioanna Chinou;A. Jennifer Rivett

  • Proteasome dysfunction in mammalian aging: Steps and factors involved

    Niki Chondrogianni;Efstathios S Gonos

  • Chemical analysis of Greek pollen - Antioxidant, antimicrobial and proteasome activation properties

    Konstantia Graikou;Suzanne Kapeta;Nektarios Aligiannis;George Sotiroudis

  • Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex

    Ioannis P. Trougakos;Magda Lourda;Marianna H. Antonelou;Dimitris Kletsas

  • The genetics of human longevity.

    Miriam Capri;Stefano Salvioli;Federica Sevini;Silvana Valensin

Frequent Co-Authors

Claudio Franceschi
Claudio Franceschi University of Bologna
Olivier Toussaint
Olivier Toussaint University of Namur
Ewa Sikora
Ewa Sikora Polish Academy of Sciences
Tilman Grune
Tilman Grune University of Potsdam
Alexander Bürkle
Alexander Bürkle University of Konstanz
Marco Malavolta
Marco Malavolta Advanced Technology Center
Beatrix Grubeck-Loebenstein
Beatrix Grubeck-Loebenstein University of Innsbruck
Miriam Capri
Miriam Capri University of Bologna
Bertrand Friguet
Bertrand Friguet Sorbonne University
Mikko Hurme
Mikko Hurme Tampere University

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