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Biology and Biochemistry

D-Index
55
Citations
11865
World Ranking
14972
National Ranking
1064

Overview

Irmela Jeremias is a researcher affiliated with Ludwig-Maximilians-Universität München in Germany. Their work spans a broad range of topics primarily within biochemistry, genetics, molecular biology, and medicine.

Their research focuses on areas including acute myeloid leukemia, CAR-T cell therapy, protein degradation and inhibitors, CRISPR and genetic engineering, acute lymphoblastic leukemia, advanced biosensing and bioanalysis techniques, and histone deacetylase inhibitors. These topics illustrate a multidisciplinary approach linking molecular biology and clinical applications.

The subfields of study associated with Jeremias include molecular biology, hematology, oncology, genetics, and public health, environmental, and occupational health. These fields reflect an integration of fundamental biological mechanisms with disease-oriented investigations.

Some of Jeremias's frequently collaborating co-authors are Binje Vick, Tobias Herold, Michela Carlet, Diana Amend, and Karsten Spiekermann. Collaborations appear to be a significant aspect of their research productivity.

Frequent publication venues for Jeremias include Blood, Klinische Pädiatrie, Leukemia, bioRxiv (Cold Spring Harbor Laboratory), and HemaSphere. These journals and platforms emphasize areas of hematology, oncology, and clinical pediatrics.

Representative recent papers authored or co-authored by Jeremias include:

  • Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia (2021, Nature)
  • Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy (2020, Nature Medicine)
  • T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals (2022, Blood)
  • Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR (2020, Blood)
  • Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia (2020, Cancer Cell)

Best Publications

  • Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.

    Eliza Yankova;Eliza Yankova;Wesley Blackaby;Mark Albertella;Justyna Rak;Justyna Rak

  • The target landscape of clinical kinase drugs

    Susan Klaeger;Susan Klaeger;Stephanie Heinzlmeir;Stephanie Heinzlmeir;Mathias Wilhelm;Harald Polzer;Harald Polzer

  • CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons.

    Ana Martin-Villalba;Ingrid Herr;Irmela Jeremias;Michael Hahne

  • TRAIL/Apo‐2‐ligand‐induced apoptosis in human T cells

    Irmela Jeremias;Ingrid Herr;Thomas Boehler;Klaus-Michael Debatin;Klaus-Michael Debatin

  • TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.

    Harald Ehrhardt;Simone Fulda;Irene Schmid;John Hiscott

  • Interleukin-1 receptor antagonist and interleukin-6 for early diagnosis of neonatal sepsis 2 days before clinical manifestation

    Helmut Küster;Michael Weiss;Andreas E Willeitner;Stefanie Detlefsen

  • Involvement of CD95/Apo1/Fas in Cell Death After Myocardial Ischemia

    I. Jeremias;C. Kupatt;A. Martin-Villalba;H. Habazettl

  • The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

    Elizabeth C. Townsend;Mark A. Murakami;Alexandra Christodoulou;Amanda L. Christie

  • Inhibition of Nuclear Factor κB Activation Attenuates Apoptosis Resistance in Lymphoid Cells

    I. Jeremias;C. Kupatt;B. Baumann;I. Herr

  • Betulinic acid: A new cytotoxic agent against malignant brain-tumor cells

    Simone Fulda;Irmela Jeremias;Hans H. Steiner;Torsten Pietsch

  • Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

    Sarah Ebinger;Erbey Ziya Özdemir;Christoph Ziegenhain;Sebastian Tiedt

  • Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism.

    C Krupka;P Kufer;R Kischel;G Zugmaier

  • Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

    Stefanie Göllner;Thomas Oellerich;Thomas Oellerich;Shuchi Agrawal-Singh;Tino Schenk

  • Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

    A. Moretti;L. Fonteyne;F. Giesert;P. Hoppmann

  • Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2–mediated resistance

    Melanie Fakler;Sandra Loeder;Meike Vogler;Katja Schneider

  • Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body

    Chenchen Pan;Oliver Schoppe;Arnaldo Parra-Damas;Ruiyao Cai

  • Betulinic acid-induced apoptosis in leukemia cells.

    H Ehrhardt;S Fulda;M Fuhrer;Klaus-Michael Debatin

  • MycN and IFNγ cooperate in apoptosis of human neuroblastoma cells

    Werner Lutz;Simone Fulda;Irmela Jeremias;Klaus Michael Debatin

  • MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.

    Juliana M. Benito;Laura Godfrey;Kensuke Kojima;Leah Hogdal

  • Smac Mimetic Bypasses Apoptosis Resistance in FADD- or Caspase-8-Deficient Cells by Priming for Tumor Necrosis Factor α-Induced Necroptosis

    Bram Laukens;Claudia Jennewein;Barbara Schenk;Nele Vanlangenakker;Nele Vanlangenakker

Frequent Co-Authors

Klaus-Michael Debatin
Klaus-Michael Debatin University of Ulm
Simone Fulda
Simone Fulda Goethe University Frankfurt
Wolfgang Hiddemann
Wolfgang Hiddemann Ludwig-Maximilians-Universität München
Wolfgang Enard
Wolfgang Enard Ludwig-Maximilians-Universität München
Christian Peschel
Christian Peschel Technical University of Munich
Angelika M. Vollmar
Angelika M. Vollmar Ludwig-Maximilians-Universität München
George S. Vassiliou
George S. Vassiliou University of Cambridge
Roland Rad
Roland Rad Technical University of Munich
Mathieu J.M. Bertrand
Mathieu J.M. Bertrand Ghent University
Heinrich Leonhardt
Heinrich Leonhardt Ludwig-Maximilians-Universität München

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