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Biology and Biochemistry

D-Index
60
Citations
22569
World Ranking
11688
National Ranking
901

Overview

George S. Vassiliou is affiliated with the University of Cambridge in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in Molecular Biology, Hematology, Genetics, Cancer Research, and Immunology.

The main topics addressed in their work include:

  • Acute Myeloid Leukemia Research
  • Cancer Genomics and Diagnostics
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Protein Degradation and Inhibitors
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Hematopoietic Stem Cell Transplantation

Recent publications by George S. Vassiliou reflect a focus on hematopoiesis and leukemia, including:

  • Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia, 2021, Nature
  • Clonal dynamics of haematopoiesis across the human lifespan, 2022, Nature
  • METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation, 2021, Molecular Cell
  • The longitudinal dynamics and natural history of clonal haematopoiesis, 2022, Nature
  • Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis, 2022, Nature Genetics

Frequent collaborators in their research include:

  • Margarete A. Fabre
  • Muxin Gu
  • Brian J.P. Huntly
  • Malgorzata Gozdecka
  • Konstantinos Tzelepis

George S. Vassiliou's work has been published extensively in several key scientific journals and platforms, indicating a strong presence in hematology and genetics research communities. Frequent publication venues include:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Genetics
  • Nature
  • Zenodo (CERN European Organization for Nuclear Research)

Best Publications

  • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.

    E Joanna Baxter;Linda M Scott;Peter J Campbell;Clare East

  • Promoter-bound METTL3 maintains myeloid leukaemia by m 6 A-dependent translation control

    Isaia Barbieri;Konstantinos Tzelepis;Luca Pandolfini;Junwei Shi

  • Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study

    Peter J Campbell;Linda M Scott;Georgina Buck;Keith Wheatley

  • Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.

    Eliza Yankova;Eliza Yankova;Wesley Blackaby;Mark Albertella;Justyna Rak;Justyna Rak

  • A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

    Konstantinos Tzelepis;Hiroko Koike-Yusa;Etienne De Braekeleer;Yilong Li

  • Prediction of acute myeloid leukaemia risk in healthy individuals

    Sagi Abelson;Grace Collord;Grace Collord;Stanley W.K. Ng;Omer Weissbrod

  • Effect of Mutation Order on Myeloproliferative Neoplasms

    Christina A. Ortmann;David G. Kent;Jyoti Nangalia;Yvonne Silber

  • Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis

    Thomas McKerrell;Naomi Park;Thaidy Moreno;Carolyn S. Grove

  • Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

    Y S Ju;L B Alexandrov;M Gerstung;I Martincorena

  • Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

    Sebastian Mueller;Thomas Engleitner;Thomas Engleitner;Roman Maresch;Roman Maresch;Magdalena Zukowska

  • PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.

    Joanne I. Hsu;Joanne I. Hsu;Tajhal Dayaram;Ayala Tovy;Etienne De Braekeleer;Etienne De Braekeleer

  • PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice

    Roland Rad;Lena Rad;Wei Wang;Juan Cadinanos

  • Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

    George S Vassiliou;Jonathan L Cooper;Roland Rad;Juan Li

  • Targeting chromatin regulators inhibits leukemogenic gene expression in npm1 mutant leukemia

    Scott A. Armstrong

  • A Genetic Progression Model of BrafV600E-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention

    Roland Rad;Roland Rad;Roland Rad;Juan Cadiñanos;Lena Rad;Ignacio Varela

  • Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?

    Carolyn S. Grove;George S. Vassiliou

  • METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.

    Esteban A. Orellana;Esteban A. Orellana;Qi Liu;Qi Liu;Eliza Yankova;Eliza Yankova;Mehdi Pirouz;Mehdi Pirouz

  • CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice

    Julia Weber;Julia Weber;Rupert Öllinger;Mathias Friedrich;Ursula Ehmer

  • Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib.

    Lynn Quek;Muriel D David;Alison Kennedy;Marlen Metzner

  • Critical evaluation of KCNJ3 gene product detection in human breast cancer: mRNA in situ hybridisation is superior to immunohistochemistry.

    Sarah Kammerer;Stephan Wenzel Jahn;Elke Winter;Sylvia Eidenhammer

Frequent Co-Authors

Roland Rad
Roland Rad Technical University of Munich
Allan Bradley
Allan Bradley University of Cambridge
Peter J. Campbell
Peter J. Campbell Wellcome Sanger Institute
Kosuke Yusa
Kosuke Yusa Kyoto University
Ultan McDermott
Ultan McDermott AstraZeneca (United Kingdom)
Pentao Liu
Pentao Liu University of Hong Kong
Anthony R. Green
Anthony R. Green University of Cambridge
Paul Kellam
Paul Kellam Imperial College London
Tony Kouzarides
Tony Kouzarides University of Cambridge
Roland M. Schmid
Roland M. Schmid Technical University of Munich

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