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Genetics and Molecular Biology
UK
2024
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Molecular Biology
UK
2023

D-Index & Metrics

Molecular Biology

D-Index
125
Citations
99856
World Ranking
222
National Ranking
14

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2023 - Research.com Molecular Biology in United Kingdom Leader Award
  • 2018 - Fellow of the American Academy of Arts and Sciences
  • 2012 - Fellow of the Royal Society, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Tony Kouzarides is affiliated with the University of Cambridge in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a notable emphasis on molecular biology, cancer research, and oncology. Their work spans multiple subfields including computational theory, infectious diseases, and molecular mechanisms related to cancer.

The scientist's major research topics include:

  • RNA modifications and cancer
  • Cancer-related molecular mechanisms research
  • RNA research and splicing
  • RNA and protein synthesis mechanisms
  • Cancer-related gene regulation
  • Extracellular vesicles in disease
  • Computational drug discovery methods

Key recent publications by Tony Kouzarides include:

  • "Role of RNA modifications in cancer," 2020, published in Nature Reviews. Cancer
  • "Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia," 2021, Nature
  • "RNA modifications detection by comparative Nanopore direct RNA sequencing," 2021, Nature Communications
  • "Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication," 2021, Genes & Development
  • "Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression," 2022, Gut

The scientist collaborates frequently with a number of co-authors, including:

  • Andrew J. Bannister
  • Namshik Han
  • Isaia Barbieri
  • Konstantinos Tzelepis
  • Luca Pandolfini

Publications are often featured in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Molecular Cell
  • Nature Reviews. Cancer
  • Nature

Tony Kouzarides has been recognized with several awards, including being named a Fellow of the American Academy of Arts and Sciences in 2018 and a Fellow of the Royal Society, United Kingdom, in 2012. The scientist is also a member of the European Molecular Biology Organization (EMBO) and a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Chromatin Modifications and Their Function

    Tony Kouzarides

  • Regulation of chromatin by histone modifications

    Andrew J Bannister;Tony Kouzarides

  • Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.

    Andrew J. Bannister;Philip Zegerman;Janet F. Partridge;Eric A. Miska

  • Cancer epigenetics: from mechanism to therapy.

    Mark A. Dawson;Tony Kouzarides

  • Active genes are tri-methylated at K4 of histone H3

    Helena Santos-Rosa;Robert Schneider;Andrew J. Bannister;Julia Sherriff

  • The CBP co-activator is a histone acetyltransferase

    Andrew J. Bannister;Tony Kouzarides

  • An operational definition of epigenetics

    Shelley L. Berger;Tony Kouzarides;Ramin Shiekhattar;Ali Shilatifard

  • Analysis of the Protein-Coding Content of the Sequence of Human Cytomegalovirus Strain AD169

    M. S. Chee;A. T. Bankier;S. Beck;R. Bohni

  • Retinoblastoma protein recruits histone deacetylase to repress transcription

    Alexander Brehm;Eric A. Miska;Dennis J. McCance;Dennis J. McCance;Juliet L. Reid

  • Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

    Mark A. Dawson;Rab K. Prinjha;Antje Dittmann;George Giotopoulos

  • Acetylation: a regulatory modification to rival phosphorylation?

    Tony Kouzarides

  • The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone Methylation

    François Fuks;Paul J. Hurd;Daniel Wolf;Xinsheng Nan

  • Histone methylation in transcriptional control.

    Tony Kouzarides

  • DNA methyltransferase Dnmt1 associates with histone deacetylase activity.

    François Fuks;Wendy A. Burgers;Alexander Brehm;Luke Hughes-Davies

  • Rb targets histone H3 methylation and HP1 to promoters

    Soren J. Nielsen;Robert Schneider;Uta-Maria Bauer;Andrew J. Bannister

  • New nomenclature for chromatin-modifying enzymes.

    C. David Allis;Shelley L. Berger;Jacques Cote;Sharon R Dent

  • Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

    Emma Langley;Mark Pearson;Mark Pearson;Mario Faretta;Uta Maria Bauer

  • Histone deimination antagonizes arginine methylation

    Graeme L. Cuthbert;Sylvain Daujat;Andrew W. Snowden;Hediye Erdjument-Bromage

  • The role of the leucine zipper in the fos–jun interaction

    T. Kouzarides;E. Ziff

  • Histone core modifications regulating nucleosome structure and dynamics

    Peter Tessarz;Tony Kouzarides

Frequent Co-Authors

Andrew J. Bannister
Andrew J. Bannister University of Cambridge
Mark A. Dawson
Mark A. Dawson Peter MacCallum Cancer Centre
Eric A. Miska
Eric A. Miska University of Cambridge
George S. Vassiliou
George S. Vassiliou University of Cambridge
Rab K. Prinjha
Rab K. Prinjha GlaxoSmithKline (United Kingdom)
Carlos Caldas
Carlos Caldas University of Cambridge
Didier Trouche
Didier Trouche Federal University of Toulouse Midi-Pyrénées
Stephen P. Jackson
Stephen P. Jackson University of Cambridge
Bart Barrell
Bart Barrell Wellcome Sanger Institute
Shelley L. Berger
Shelley L. Berger University of Pennsylvania

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