Yang Shi is a researcher affiliated with the University of Oxford in the United Kingdom, with a primary focus on medicine. Their work spans several subfields, including molecular biology, physiology, neurology, organic chemistry, and plant science. The main areas of research emphasize Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, acute myeloid leukemia research, cholesterol and lipid metabolism, cancer immunotherapy and biomarkers, sphingolipid metabolism and signaling, and viral infections and immunology research.
Their recent publications reflect a focus on neurological disorders and related cellular mechanisms. Notable papers include "Cholesterol and matrisome pathways dysregulated in astrocytes and microglia" (2022, Cell), "Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia" (2021, Neuron), and "Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms" (2021, Neuron). Earlier work includes investigations into microglial inflammatory responses and lipoprotein roles in neurodegeneration, such as "25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner" (2020, Journal of Neuroinflammation) and "High-density lipoprotein in Alzheimer's disease: From potential biomarkers to therapeutics" (2021, Journal of Controlled Release).
Yang Shi frequently collaborates with researchers like David M. Holtzman, Mendel Goldfinger, Ioannis Mantzaris, Marina Konopleva, and Kira Gritsman. These collaborations contribute to their multidisciplinary approach, covering areas across neurology, immunology, and cancer research.
The researcher has published in a range of scientific venues, with multiple contributions to journals such as Blood, Alzheimer's & Dementia, Cancer Research, Neuron, and the Journal of Controlled Release. These journals correspond to the diverse topics they investigate, from neurodegeneration and Alzheimer's disease to cancer and immunology.
Research topics commonly addressed in Yang Shi's publications include:
Overall, Yang Shi's body of work contributes to a better understanding of disease mechanisms at the molecular and cellular levels, especially in neurological and oncological contexts. Their interdisciplinary collaborations and frequent publications in high-impact journals indicate a consistent engagement with complex biomedical challenges.
Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham
Yang Shi;Yujiang Shi
Miao-Chih Tsai;Ohad Manor;Yue Wan;Nima Mosammaparast
Eric L. Greer;Yang Shi
Guangchao Sui;Christina Soohoo;El Bachir Affar
Yang Shi;Edward Seto;Long Sheng Chang;Thomas Shenk
Johnathan R. Whetstine;Amanda Nottke;Fei Lan;Maite Huarte
Xiaobing Shi;Tao Hong;Kay L. Walter;Mark Ewalt
C. David Allis;Shelley L. Berger;Jacques Cote;Sharon R Dent
Yu Jiang Shi;Caitlin Matson;Fei Lan;Shigeki Iwase
Mary E. Gerritsen;Amy J. Williams;Andrew S. Neish;Sarah Moore
Yang Shi;Johnathan R. Whetstine
Fei Lan;Peter E. Bayliss;John L. Rinn;Johnathan R. Whetstine
Yujiang Shi;Jun-ichi Sawada;Guangchao Sui;El Bachir Affar
Yang Xiang;Benoit Laurent;Benoit Laurent;Chih-Hung Hsu;Chih-Hung Hsu;Sigrid Nachtergaele
Yang Shi
Nima Mosammaparast;Yang Shi
Shigeki Iwase;Fei Lan;Peter Bayliss;Luis de la Torre-Ubieta
Jing Wen;Ruitu Lv;Honghui Ma;Hongjie Shen
Ji Ying Sze;Martin Victor;Curtis Loer;Yang Shi
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