World's Best Scientists 2026 revealed!
Thomas M. Roberts

Thomas M. Roberts

D-Index & Metrics

Molecular Biology

D-Index
115
Citations
52525
World Ranking
305
National Ranking
184

Overview

Thomas M. Roberts is affiliated with Harvard University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with numerous publications highlighting expertise in these areas.

They have contributed extensively to subfields such as Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Immunology, and Cancer Research. The scientist's work addresses key topics including PI3K/AKT/mTOR signaling in cancer, interferon and immune responses, PARP inhibition in cancer therapy, cancer genomics and diagnostics, cancer-related molecular pathways, cancer lipids and metabolism, and antimicrobial agents and applications.

Thomas M. Roberts has authored several papers in prominent journals. Selected recent publications include:

  • "TMTpro-18plex: The Expanded and Complete Set of TMTpro Reagents for Sample Multiplexing" (2021), Journal of Proteome Research
  • "STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer" (2022), Nature Communications
  • "PI3Kβ controls immune evasion in PTEN-deficient breast tumours" (2023), Nature
  • "STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer" (2023), Journal for ImmunoTherapy of Cancer
  • "Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer" (2021), Journal for ImmunoTherapy of Cancer

Frequent coauthors who have collaborated with Thomas M. Roberts include:

  • Jean J. Zhao
  • Shaozhen Xie
  • Qiwei Wang
  • Johann S. Bergholz
  • Hye-Jung Kim

The scientist's work has been published regularly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature
  • Journal for ImmunoTherapy of Cancer
  • Blood

Best Publications

  • SH2 domains recognize specific phosphopeptide sequences

    Songyang Zhou;Songyang Zhou;Steven E. Shoelson;Manas Chaudhuri;Gerald Gish

  • Targeting the phosphoinositide 3-kinase pathway in cancer.

    Pixu Liu;Hailing Cheng;Thomas M. Roberts;Jean J. Zhao

  • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

    Cory M Johannessen;Jesse S. Boehm;So Young Kim;Sapana R. Thomas;Sapana R. Thomas

  • CDK4/6 inhibition triggers anti-tumour immunity

    Shom Goel;Molly J. DeCristo;April C. Watt;Haley BrinJones

  • ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

    Kenneth W. Wood;Charlyn Sarnecki;Thomas M. Roberts;John Blenis

  • Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation.

    Malcolm Whitman;David R. Kaplan;Brian Schaffhausen;Lewis Cantley

  • Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

    Paul Dent;Wayne Haser;Timothy A. J. Haystead;Leigh Ann Vincent

  • A histone H3 lysine 27 demethylase regulates animal posterior development.

    Fei Lan;Peter E. Bayliss;John L. Rinn;Johnathan R. Whetstine

  • Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

    Shidong Jia;Zhenning Liu;Sen Zhang;Pixu Liu

  • Regulation of G1 Progression by the PTEN Tumor Suppressor Protein Is Linked to Inhibition of the Phosphatidylinositol 3-kinase/Akt Pathway

    Shivapriya Ramaswamy;Noriaki Nakamura;Francisca Vazquez;David B. Batt

  • Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

    David C. Pallas;Lilian K. Shahrik;Bruce L. Martin;Stephen Jaspers

  • Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

    Trevor J Pugh;Trevor J Pugh;Shyamal Dilhan Weeraratne;Shyamal Dilhan Weeraratne;Tenley C. Archer;Tenley C. Archer;Daniel A. Pomeranz Krummel

  • The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases

    Shigeki Iwase;Fei Lan;Peter Bayliss;Luis de la Torre-Ubieta

  • Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

    David R. Kaplan;Malcolm Whitman;Brian Schaffhausen;David C. Pallas

  • KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

    Diane D. Shao;Wen Xue;Elsa B. Krall;Elsa B. Krall;Arjun Bhutkar

  • Integrative genomic approaches identify IKBKE as a breast cancer oncogene.

    Jesse S. Boehm;Jean J. Zhao;Jun Yao;So Young Kim

  • Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family.

    Takashi K. Kishimoto;Karen O'Connor;Alice Lee;Thomas M. Roberts

  • Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

    Deborah K. Morrison;David R. Kaplan;Ulf Rapp;Thomas M. Roberts

  • Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src.

    Helen Piwnica-Worms;Kim B Saunders;Thomas M Roberts;Alan E Smith

  • An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide)

    Manav Korpal;Joshua M. Korn;Xueliang Gao;Daniel P. Rakiec

Frequent Co-Authors

Brian Schaffhausen
Brian Schaffhausen Tufts University
Murray Stewart
Murray Stewart MRC Laboratory of Molecular Biology
William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
David C. Pallas
David C. Pallas Emory University
Mark Ptashne
Mark Ptashne Memorial Sloan Kettering Cancer Center
Lewis C. Cantley
Lewis C. Cantley Harvard University
David L. Kaplan
David L. Kaplan Tufts University
Ana C. Carrera
Ana C. Carrera Spanish National Research Council
Massimo Loda
Massimo Loda Cornell University

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