World's Best Scientists 2026 revealed!
William R. Sellers

William R. Sellers

D-Index & Metrics

Medicine

D-Index
132
Citations
104461
World Ranking
2263
National Ranking
1280

Research.com Recognitions

  • 1873 - Member of the National Academy of Sciences
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

William R. Sellers is affiliated with Harvard University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Cancer Research, and Surgery.

The scientist's work covers several main topics, including:

  • Cancer-related gene regulation
  • Protein Degradation and Inhibitors
  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Ubiquitin and proteasome pathways
  • Advanced Breast Cancer Therapies
  • Fibroblast Growth Factor Research

William R. Sellers has contributed multiple papers with notable publication venues and years:

  • Quantitative Proteomics of the Cancer Cell Line Encyclopedia, 2020, Cell
  • Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer, 2020, Journal of Medicinal Chemistry
  • Targeting pan-essential genes in cancer: Challenges and opportunities, 2021, Cancer Cell
  • Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers, 2021, Nature Genetics
  • Molecular basis for substrate recruitment to the PRMT5 methylosome, 2021, Molecular Cell

Frequent coauthors include:

  • Devishi Kesar, with 14 joint publications
  • Diego J. Rodriguez, with 11 joint publications
  • Ruitong Li, with 9 joint publications
  • Kathleen M. Mulvaney, with 9 joint publications
  • Saireudee Chaturantabut, with 9 joint publications

Common publication venues where their work appears frequently consist of:

  • Cancer Research (21 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (7 publications)
  • Nature Genetics (3 publications)
  • Molecular Cancer Therapeutics (3 publications)
  • Cell (2 publications)

Among their recognized achievements are membership honors including:

  • Member of the National Academy of Sciences (1873)
  • Member of the Association of American Physicians

Best Publications

  • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

    J. Guillermo Paez;Pasi A. Jänne;Pasi A. Jänne;Jeffrey C. Lee;Sean Tracy

  • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

    Jordi Barretina;Giordano Caponigro;Nicolas Stransky;Kavitha Venkatesan

  • The landscape of somatic copy-number alteration across human cancers

    Rameen Beroukhim;Craig H. Mermel;Craig H. Mermel;Dale Porter;Guo Wei

  • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

    Ross L. Levine;Ross L. Levine;Martha Wadleigh;Jan Cools;Benjamin L. Ebert;Benjamin L. Ebert

  • Gene expression correlates of clinical prostate cancer behavior.

    Dinesh Singh;Phillip G. Febbo;Phillip G. Febbo;Kenneth Ross;Donald G. Jackson

  • Next-generation characterization of the Cancer Cell Line Encyclopedia

    Mahmoud Ghandi;Franklin W. Huang;Franklin W. Huang;Franklin W. Huang;Judit Jané-Valbuena;Judit Jané-Valbuena;Gregory V. Kryukov

  • Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

    Levi A. Garraway;Hans R. Widlund;Mark A. Rubin;Gad Getz

  • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

    Ingo K. Mellinghoff;Maria Y. Wang;Igor Vivanco;Daphne A. Haas-Kogan

  • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

    Cory M Johannessen;Jesse S. Boehm;So Young Kim;Sapana R. Thomas;Sapana R. Thomas

  • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

    Sauveur-Michel Maira;Frédéric Stauffer;Josef Brueggen;Pascal Furet

  • Molecular characterization of the tumor microenvironment in breast cancer

    Minna Allinen;Rameen Beroukhim;Li Cai;Cameron Brennan

  • BRAF mutation predicts sensitivity to MEK inhibition

    David B. Solit;Levi A. Garraway;Levi A. Garraway;Christine A. Pratilas;Ayana Sawai

  • High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

    Hui Gao;Joshua M Korn;Stéphane Ferretti;John E Monahan

  • Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

    Rameen Beroukhim;Gad Getz;Leia Nghiemphu;Jordi Barretina

  • The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway

    Isabelle Sansal;William R. Sellers

  • High-throughput oncogene mutation profiling in human cancer

    Roman K. Thomas;Alissa C. Baker;Ralph M. DeBiasi;Ralph M. DeBiasi;Wendy Winckler;Wendy Winckler

  • mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

    Pradip K Majumder;Phillip G Febbo;Phillip G Febbo;Rachel Bikoff;Rachel Bikoff;Raanan Berger;Raanan Berger

  • Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

    William G. Kaelin;Wilhelm Krek;William R. Sellers;James A. DeCaprio

  • Phosphorylation of the PTEN Tail Regulates Protein Stability and Function

    Francisca Vazquez;Shivapriya Ramaswamy;Noriaki Nakamura;William R. Sellers

  • Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.

    Máirín E. McMenamin;Peggy Soung;Sauni Perera;Irving Kaplan

Frequent Co-Authors

Levi A. Garraway
Levi A. Garraway Roche (United States)
Matthew Meyerson
Matthew Meyerson Harvard University
Rameen Beroukhim
Rameen Beroukhim Harvard University
Todd R. Golub
Todd R. Golub Harvard University
Heidi Greulich
Heidi Greulich Broad Institute
Jordi Barretina
Jordi Barretina Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
Massimo Loda
Massimo Loda Cornell University
Mark A. Rubin
Mark A. Rubin University of Bern
Pasi A. Jänne
Pasi A. Jänne Harvard University
William G. Kaelin
William G. Kaelin Harvard University

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