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Chemistry

D-Index
51
Citations
8867
World Ranking
13998
National Ranking
574

Overview

Siden Top is affiliated with Chimie ParisTech in France. Their research primarily focuses on the field of Chemistry, with significant contributions to Organic Chemistry and subfields such as Materials Chemistry, Electrical and Electronic Engineering, Molecular Biology, and Toxicology. The main topics of their work include:

  • Ferrocene Chemistry and Applications
  • Synthesis and biological activity
  • Molecular Junctions and Nanostructures
  • Organometallic Complex Synthesis and Catalysis
  • Cancer therapeutics and mechanisms
  • Bioactive Compounds and Antitumor Agents
  • Metal complexes synthesis and properties

Their recent publications cover a range of research within organometallic chemistry and bioactive compound development, specifically featuring:

  • "Oxidation of Cymantrene-Tagged Tamoxifen Analogues: Effect of Diphenyl Functionalization on the Redox Mechanism," 2020, Organometallics
  • "Antimicrobial, Antitumor and Side Effects Assessment of a Newly Synthesized Tamoxifen Analog," 2020, Current Topics in Medicinal Chemistry
  • "Inhibition of Cathepsin B by Ferrocenyl Indenes Highlights a new Pharmacological Facet of Ferrocifens," 2022, European Journal of Inorganic Chemistry
  • "CCDC 2382616: Experimental Crystal Structure Determination," 2025, The Cambridge Structural Database
  • "Biological evaluation and molecular docking study of Ferrociphenol as an anti-melanogenic agent," 2025, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in their research include:

  • Gérard Jaouen
  • Pascal Pigeon
  • Mehdi El Arbi
  • Emna Ketata
  • Anne Vessières

Their work has appeared in various scientific venues such as:

  • Organometallics
  • Current Topics in Medicinal Chemistry
  • European Journal of Inorganic Chemistry
  • The Cambridge Structural Database
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Ferrocifen type anti cancer drugs.

    Gérard Jaouen;Anne Vessières;Anne Vessières;Siden Top;Siden Top

  • Synthesis, biochemical properties and molecular modelling studies of organometallic specific estrogen receptor modulators (SERMs), the ferrocifens and hydroxyferrocifens: evidence for an antiproliferative effect of hydroxyferrocifens on both hormone-dependent and hormone-independent breast cancer cell lines.

    Siden Top;Anne Vessières;Guy Leclercq;Jacques Quivy

  • The first organometallic selective estrogen receptor modulators (SERMs) and their relevance to breast cancer

    Gérard Jaouen;Siden Top;Anne Vessières;Guy Leclercq

  • Studies on organometallic selective estrogen receptor modulators. (SERMs) Dual activity in the hydroxy-ferrocifen series

    Siden Top;Anne Vessières;Claude Cabestaing;Ioanna Laïos

  • Ferrocenyl hydroxytamoxifen: a prototype for a new range of oestradiol receptor site-directed cytotoxics

    Siden Top;Jie Tang;Anne Vessières;Danièle Carrez

  • Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of antiproliferative effects in vitro.

    Anne Vessières;Siden Top;Pascal Pigeon;Elizabeth Hillard

  • Rhenium Carbonyl Complexes of .beta.-Estradiol Derivatives with High Affinity for the Estradiol Receptor: An Approach to Selective Organometallic Radiopharmaceuticals

    Siden Top;Hassane El Hafa;Anne Vessieres;Jacques Quivy

  • Ferrocenyl Quinone Methides as Strong Antiproliferative Agents: Formation by Metabolic and Chemical Oxidation of Ferrocenyl Phenols

    Didier Hamels;Patrick M. Dansette;Elizabeth A. Hillard;Siden Top

  • FACILE ROUTE TO FERROCIFEN, 1-4-(2-DIMETHYLAMINOETHOXY)-1-(PHENYL-2-FERROCENYL-BUT-1-ENE), FIRST ORGANOMETALLIC ANALOGUE OF TAMOXIFEN, BY THE MCMURRY REACTION

    Siden Top;Bénédicte Dauer;Jacqueline Vaissermann;Gérard Jaouen

  • Ferrocifens and ferrocifenols as new potential weapons against breast cancer

    Anh Nguyen;Anne Vessières;Elisabeth A. Hillard;Siden Top

  • New paradigms for synthetic pathways inspired by bioorganometallic chemistry

    Gérard Jaouen;Siden Top;Anne Vessières;Roger Alberto

  • Metal complex SERMs (selective oestrogen receptor modulators). The influence of different metal units on breast cancer cell antiproliferative effects

    Anne Vessières;Siden Top;Wolfgang Beck;Elizabeth Hillard

  • Organometallic estrogens: synthesis, interaction with lamb uterine estrogen receptor, and detection by infrared spectroscopy.

    Anne Vessieres;Siden Top;Ashraf A. Ismail;Ian S. Butler

  • Selective Estrogen Receptor Modulators in the Ruthenocene Series. Synthesis and Biological Behavior

    Pascal Pigeon;Siden Top;Anne Vessieres;Michel Huche

  • N-Alkylation of nitriles using chromium tricarbonyl complexes of benzyl alcohol and its derivatives: new perspectives for the Ritter reaction

    Siden Top;Gerard Jaouen

  • Labeling of proteins by organometallic complexes of rhenium(I). Synthesis and biological activity of the conjugates

    Michele Salmain;Michele Gunn;Abdellaziz Gorfti;Siden Top

  • METAL CARBONYL FRAGMENTS AS A NEW CLASS OF MARKERS IN MOLECULAR BIOLOGY

    G. Jaouen;A. Vessieres;S. Top;A. A. Ismail

  • Synthesis and structure-activity relationships of the first ferrocenyl-aryl-hydantoin derivatives of the nonsteroidal antiandrogen nilutamide.

    Olivier Payen;Siden Top;Anne Vessières;Emilie Brulé

  • Evidence for targeting thioredoxin reductases with ferrocenyl quinone methides. A possible molecular basis for the antiproliferative effect of hydroxyferrocifens on cancer cells.

    Anna Citta;Alessandra Folda;Alberto Bindoli;Pascal Pigeon;Pascal Pigeon;Pascal Pigeon

  • Chromium tricarbonyl complexes of estradiol derivatives: differentiation of .alpha.- and .beta.-diastereoisomers using 1- and 2-dimensional NMR spectroscopy at 500 MHz

    Siden. Top;Gerard. Jaouen;Anne. Vessieres;Jean Pierre. Abjean

  • Ferrocifen Type Anticancer Drugs

    Gerard Jaouen;Anne Vessieres;Siden Top

Frequent Co-Authors

Gérard Jaouen
Gérard Jaouen Chimie ParisTech
Anne Vessières
Anne Vessières Université Paris Cité
Michael J. McGlinchey
Michael J. McGlinchey University College Dublin
Christian Amatore
Christian Amatore École Normale Supérieure
Ian S. Butler
Ian S. Butler McGill University
Jean-Paul Mornon
Jean-Paul Mornon Sorbonne University
Helge Müller-Bunz
Helge Müller-Bunz University College Dublin
Domenico Osella
Domenico Osella University of Eastern Piedmont Amadeo Avogadro
Daniel Mansuy
Daniel Mansuy Université Paris Cité
Roger Alberto
Roger Alberto University of Zurich

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