The scientist’s investigation covers issues in Stereochemistry, Ferrocene, Tamoxifen, Organic chemistry and Estrogen receptor. His research integrates issues of Steroid, Chemical synthesis and Oestradiol receptor in his study of Stereochemistry. The Steroid study which covers Infrared spectroscopy that intersects with Biochemistry.
His Ferrocifen study in the realm of Ferrocene connects with subjects such as Structure–activity relationship, Lipophilicity, Medicinal chemistry and Yield. He has included themes like Anti tumour and Beta-Estradiol in his Organic chemistry study. His study in the field of Selective estrogen receptor modulator is also linked to topics like Cytotoxicity.
His main research concerns Stereochemistry, Organic chemistry, Ferrocene, Moiety and Estrogen receptor. His Stereochemistry study integrates concerns from other disciplines, such as Steroid, Chemical synthesis and Cytotoxicity. His work carried out in the field of Cytotoxicity brings together such families of science as Cytotoxic T cell, IC50 and Structure–activity relationship.
His Organic chemistry research is multidisciplinary, incorporating perspectives in Combinatorial chemistry and Medicinal chemistry. The various areas that Siden Top examines in his Moiety study include Substituent, Molecule and Molecular model. His Selective estrogen receptor modulator study in the realm of Tamoxifen interacts with subjects such as Active metabolite, Organometallic chemistry and Ferrocifen.
His primary scientific interests are in Stereochemistry, Cytotoxicity, Ferrocifen, Redox and Cytotoxic T cell. The study incorporates disciplines such as In vitro and Manganese in addition to Stereochemistry. His Cytotoxicity research includes elements of IC50 and Structure–activity relationship.
His research investigates the connection between Structure–activity relationship and topics such as Surface modification that intersect with problems in Organic chemistry. The study of Ferrocifen is intertwined with the study of Ferroquine in a number of ways. Cytotoxic T cell is intertwined with Tamoxifen and Estrogen receptor in his study.
Siden Top mostly deals with Quinone methide, Context, Biochemistry, Ferroquine and Anti cancer drugs. Quinone methide is a primary field of his research addressed under Stereochemistry. His Context research incorporates Small molecule, Ferrocifen, Computational biology and Low toxicity.
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Synthesis, biochemical properties and molecular modelling studies of organometallic specific estrogen receptor modulators (SERMs), the ferrocifens and hydroxyferrocifens: evidence for an antiproliferative effect of hydroxyferrocifens on both hormone-dependent and hormone-independent breast cancer cell lines.
Siden Top;Anne Vessières;Guy Leclercq;Jacques Quivy.
Chemistry: A European Journal (2003)
Ferrocifen type anti cancer drugs.
Gérard Jaouen;Anne Vessières;Anne Vessières;Siden Top;Siden Top.
Chemical Society Reviews (2015)
The first organometallic selective estrogen receptor modulators (SERMs) and their relevance to breast cancer
Gérard Jaouen;Siden Top;Anne Vessières;Guy Leclercq.
Current Medicinal Chemistry (2004)
Studies on organometallic selective estrogen receptor modulators. (SERMs) Dual activity in the hydroxy-ferrocifen series
Siden Top;Anne Vessières;Claude Cabestaing;Ioanna Laïos.
Journal of Organometallic Chemistry (2001)
Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of antiproliferative effects in vitro.
Anne Vessières;Siden Top;Pascal Pigeon;Elizabeth Hillard.
Journal of Medicinal Chemistry (2005)
Ferrocenyl hydroxytamoxifen: a prototype for a new range of oestradiol receptor site-directed cytotoxics
Siden Top;Jie Tang;Anne Vessières;Danièle Carrez.
Chemical Communications (1996)
Rhenium Carbonyl Complexes of .beta.-Estradiol Derivatives with High Affinity for the Estradiol Receptor: An Approach to Selective Organometallic Radiopharmaceuticals
Siden Top;Hassane El Hafa;Anne Vessieres;Jacques Quivy.
Journal of the American Chemical Society (1995)
FACILE ROUTE TO FERROCIFEN, 1-4-(2-DIMETHYLAMINOETHOXY)-1-(PHENYL-2-FERROCENYL-BUT-1-ENE), FIRST ORGANOMETALLIC ANALOGUE OF TAMOXIFEN, BY THE MCMURRY REACTION
Siden Top;Bénédicte Dauer;Jacqueline Vaissermann;Gérard Jaouen.
Journal of Organometallic Chemistry (1997)
Ferrocifens and ferrocifenols as new potential weapons against breast cancer
Anh Nguyen;Anne Vessières;Elisabeth A. Hillard;Siden Top.
Ferrocenyl Quinone Methides as Strong Antiproliferative Agents: Formation by Metabolic and Chemical Oxidation of Ferrocenyl Phenols
Didier Hamels;Patrick M. Dansette;Elizabeth A. Hillard;Siden Top.
Angewandte Chemie (2009)
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