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Bernhard K. Keppler

Bernhard K. Keppler

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Chemistry
Austria
2026

D-Index & Metrics

Chemistry

D-Index
105
Citations
42853
World Ranking
996
National Ranking
4

Research.com Recognitions

  • 2026 - Research.com Chemistry in Austria Leader Award
  • 2025 - Research.com Chemistry in Austria Leader Award
  • 2023 - Research.com Chemistry in Austria Leader Award
  • 2022 - Research.com Chemistry in Austria Leader Award

Overview

Bernhard K. Keppler is affiliated with the University of Vienna in Austria. The primary focus of their research lies within the field of Materials Science, encompassing various subfields such as Materials Chemistry, Oncology, Organic Chemistry, Molecular Biology, and Biomaterials.

The scientist has contributed extensively to several main topics including:

  • X-ray Diffraction in Crystallography
  • Crystallization and Solubility Studies
  • Metal complexes synthesis and properties
  • Lanthanide and Transition Metal Complexes
  • Ferrocene Chemistry and Applications
  • Nanoparticle-Based Drug Delivery
  • Drug Transport and Resistance Mechanisms

Frequent publication venues for Keppler's work include:

  • The Cambridge Structural Database
  • Dalton Transactions
  • Pharmaceutics
  • Inorganic Chemistry Frontiers
  • Journal of Inorganic Biochemistry

Their collaborations often involve several co-authors, with notable frequent collaborators being:

  • Michael A. Jakupec
  • Wolfgang Kandioller
  • Michaela Hejl
  • Natalie Gajic
  • Gunda Koellensperger

Selected recent publications include:

  • "Improving the Stability of Maleimide-Thiol Conjugation for Drug Targeting" (2020), Chemistry - A European Journal
  • "Establishing electron diffraction in chemical crystallography" (2021), Nature Reviews Chemistry
  • "Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD-100/KP1339 in the Endoplasmic Reticulum" (2020), Angewandte Chemie International Edition
  • "Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands" (2021), Journal of Medicinal Chemistry
  • "Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux" (2020), Journal of Medicinal Chemistry

Best Publications

  • From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)

    Christian G. Hartinger;Stefanie Zorbas-Seifried;Michael A. Jakupec;Bernd Kynast

  • KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients.

    Christian G. Hartinger;Christian G. Hartinger;Michael A. Jakupec;Stefanie Zorbas‐Seifried;Michael Groessl

  • Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches.

    Markus Galanski;Michael A. Jakupec;Bernhard K. Keppler

  • NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

    Robert Trondl;Petra Heffeter;Christian R. Kowol;Michael A. Jakupec

  • Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology.

    Andrei R Timerbaev;Christian G Hartinger;Svetlana S Aleksenko;Bernhard K Keppler

  • Antitumour metal compounds: more than theme and variations.

    Michael A. Jakupec;Markus Galanski;Vladimir B. Arion;Christian G. Hartinger

  • Recent Developments in the Field of Tumor-Inhibiting Metal Complexes

    M. Galanski;V. B. Arion;M. A. Jakupec;B. K. Keppler

  • Metal complexes in cancer chemotherapy

    Bernhard K. Keppler

  • Anticancer activity of metal complexes: involvement of redox processes.

    Ute Jungwirth;Christian R. Kowol;Bernhard K. Keppler;Christian G. Hartinger

  • Tumour-inhibiting platinum complexes--state of the art and future perspectives.

    M. A. Jakupec;M. Galanski;B. K. Keppler

  • Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development

    Samuel M. Meier-Menches;Samuel M. Meier-Menches;Christopher Gerner;Walter Berger;Walter Berger;Christian G. Hartinger

  • Gallium in cancer treatment.

    Philippe Collery;Bernhard Keppler;Claudie Madoulet;Bernard Desoize

  • Metal Drugs and the Anticancer Immune Response.

    Bernhard Englinger;Christine Pirker;Petra Heffeter;Alessio Terenzi;Alessio Terenzi

  • Resistance against novel anticancer metal compounds: differences and similarities

    Petra Heffeter;Ute Jungwirth;Michael Jakupec;Christian Hartinger

  • The binding properties of two antitumor ruthenium(III) complexes to apotransferrin.

    F Kratz;M Hartmann;B Keppler;L Messori

  • Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells

    S. Kapitza;M. Pongratz;M. A. Jakupec;P. Heffeter

  • Electron-transfer activated metal-based anticancer drugs

    Erwin Reisner;Erwin Reisner;Vladimir B. Arion;Bernhard K. Keppler;Armando J.L. Pombeiro

  • Transferrin binding and transferrin-mediated cellular uptake of the ruthenium coordination compound KP1019, studied by means of AAS, ESI-MS and CD spectroscopy

    Martina Pongratz;Petra Schluga;Michael A. Jakupec;Vladimir B. Arion

  • Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study.

    Frederike Lentz;Anne Drescher;Andreas Lindauer;Magdalena Henke

  • Pharmacological properties of cerium compunds

    M. A. Jakupec;P. Unfried;B. K. Keppler

  • Tuning of redox potentials for the design of ruthenium anticancer drugs: an Electrochemical study of [trans-RuCl4L(DMSO)]- and [trans-RuCl4L2]- complexes, where L = imidazole, 1,2,4-triazole, indazole

    Erwin Reisner;Vladimir B Arion;M Fátima C Guedes da Silva;Roman Lichtenecker

Frequent Co-Authors

Michael A. Jakupec
Michael A. Jakupec University of Vienna
Christian G. Hartinger
Christian G. Hartinger University of Auckland
Walter Berger
Walter Berger Medical University of Vienna
Vladimir B. Arion
Vladimir B. Arion University of Vienna
Gunda Koellensperger
Gunda Koellensperger University of Vienna
Andrei R. Timerbaev
Andrei R. Timerbaev University of Vienna
Paul J. Dyson
Paul J. Dyson École Polytechnique Fédérale de Lausanne
Erwin Reisner
Erwin Reisner University of Cambridge
Stephan Hann
Stephan Hann BOKU University
Bernhard Nuber
Bernhard Nuber Heidelberg University

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